U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Acvr2b activin A receptor type 2B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25366, updated on 9-Dec-2024

    Summary

    Official Symbol
    Acvr2bprovided by RGD
    Official Full Name
    activin A receptor type 2Bprovided by RGD
    Primary source
    RGD:2028
    See related
    EnsemblRapid:ENSRNOG00000014477 AllianceGenome:RGD:2028
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables activin binding activity and inhibin binding activity. Involved in adrenal gland development and response to activity. Predicted to be located in cytoplasm. Predicted to be part of activin receptor complex. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in visceral heterotaxy. Orthologous to human ACVR2B (activin A receptor type 2B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 28.7), Kidney (RPKM 21.8) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Acvr2b in Genome Data Viewer
    Location:
    8q32
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (128016589..128056193)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (119138901..119178477)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (128087308..128126776)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene MYD88, innate immune signal transduction adaptor Neighboring gene acetyl-CoA acyltransferase 1A Neighboring gene xylulokinase Neighboring gene 40S ribosomal protein S27-like Neighboring gene exo/endonuclease G

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables BMP receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables activin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables activin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables activin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables activin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables activin binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables activin receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables activin receptor activity, type I IEA
    Inferred from Electronic Annotation
    more info
     
    enables activin receptor activity, type II IEA
    Inferred from Electronic Annotation
    more info
     
    enables activin receptor activity, type II ISO
    Inferred from Sequence Orthology
    more info
     
    enables growth factor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables growth factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables inhibin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables kinase activator activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables kinase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein serine/threonine/tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine/tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    NOT enables transforming growth factor beta binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transforming growth factor beta receptor activity, type I IEA
    Inferred from Electronic Annotation
    more info
     
    enables transforming growth factor beta receptor activity, type II IEA
    Inferred from Electronic Annotation
    more info
     
    enables transforming growth factor beta receptor activity, type III IEA
    Inferred from Electronic Annotation
    more info
     
    enables transmembrane receptor protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transmembrane receptor protein serine/threonine kinase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in BMP signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in BMP signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in activin receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in activin receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in activin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in adrenal gland development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in anterior/posterior pattern specification IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within anterior/posterior pattern specification ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in anterior/posterior pattern specification ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in artery development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in artery development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in blood vessel remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in blood vessel remodeling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell surface receptor protein serine/threonine kinase signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to growth factor stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in determination of left/right symmetry IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within determination of left/right symmetry ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in embryonic foregut morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within embryonic foregut morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in gastrulation with mouth forming second IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within gastrulation with mouth forming second ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in heart development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within heart development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in insulin secretion IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within insulin secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in kidney development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within kidney development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lung development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within lung development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lymphangiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in lymphangiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lymphatic endothelial cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in lymphatic endothelial cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mesoderm development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within mesoderm development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cold-induced thermogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of cold-induced thermogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cold-induced thermogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in odontogenesis of dentin-containing tooth IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within odontogenesis of dentin-containing tooth ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in organ growth IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within organ growth ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in pancreas development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within pancreas development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in pattern specification process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within pattern specification process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of activin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of bone mineralization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of osteoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in post-embryonic development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within post-embryonic development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein phosphorylation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within regulation of signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to activity IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to glucose IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within response to glucose ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in retina vasculature development in camera-type eye IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in retina vasculature development in camera-type eye ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in roof of mouth development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within roof of mouth development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in sexual reproduction NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within skeletal system development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in skeletal system morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within skeletal system morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in venous blood vessel development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in venous blood vessel development ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of activin receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of receptor complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of receptor complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    activin receptor type-2B
    Names
    ACTR-IIB
    ActRIIB type II activin receptor B
    Activine receptor 2b (transmembrane serine kinase)
    activin A receptor, type IIB
    activin receptor IIB
    activin receptor type IIB
    NP_113742.1
    XP_006244134.1
    XP_038936802.1
    XP_038936803.1
    XP_038936804.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031554.1NP_113742.1  activin receptor type-2B precursor

      See identical proteins and their annotated locations for NP_113742.1

      Status: PROVISIONAL

      Source sequence(s)
      BC097358
      UniProtKB/Swiss-Prot
      P38445, Q4V8J8
      UniProtKB/TrEMBL
      A0A0G2JSN4, A6I3W5
      Related
      ENSRNOP00000019777.4, ENSRNOT00000019777.8
      Conserved Domains (3) summary
      smart00220
      Location:198471
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14140
      Location:194484
      STKc_ACVR2b; Catalytic domain of the Serine/Threonine Kinase, Activin Type IIB Receptor
      pfam01064
      Location:39117
      Activin_recp; Activin types I and II receptor domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      128016589..128056193
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006244072.5XP_006244134.1  activin receptor type-2B isoform X2

      See identical proteins and their annotated locations for XP_006244134.1

      UniProtKB/TrEMBL
      A0A8I6A9R2, A6I3W4, A6I3W6
      Related
      ENSRNOP00000090538.1, ENSRNOT00000118049.2
      Conserved Domains (3) summary
      smart00220
      Location:222495
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14140
      Location:218508
      STKc_ACVR2b; Catalytic domain of the Serine/Threonine Kinase, Activin Type IIB Receptor
      pfam01064
      Location:39117
      Activin_recp; Activin types I and II receptor domain
    2. XM_039080874.2XP_038936802.1  activin receptor type-2B isoform X1

      UniProtKB/TrEMBL
      A6I3W6
      Conserved Domains (2) summary
      cd14140
      Location:227517
      STKc_ACVR2b; Catalytic domain of the Serine/Threonine Kinase, Activin Type IIB Receptor
      pfam01064
      Location:50119
      Activin_recp; Activin types I and II receptor domain
    3. XM_039080876.2XP_038936804.1  activin receptor type-2B isoform X4

      UniProtKB/Swiss-Prot
      P38445, Q4V8J8
      Conserved Domains (2) summary
      cd14140
      Location:195485
      STKc_ACVR2b; Catalytic domain of the Serine/Threonine Kinase, Activin Type IIB Receptor
      pfam01064
      Location:50119
      Activin_recp; Activin types I and II receptor domain
    4. XM_039080875.2XP_038936803.1  activin receptor type-2B isoform X3

      UniProtKB/Swiss-Prot
      P38445, Q4V8J8
      Related
      ENSRNOP00000111171.1, ENSRNOT00000129875.1
      Conserved Domains (2) summary
      cd14140
      Location:203493
      STKc_ACVR2b; Catalytic domain of the Serine/Threonine Kinase, Activin Type IIB Receptor
      pfam01064
      Location:50119
      Activin_recp; Activin types I and II receptor domain

    RNA

    1. XR_005487744.2 RNA Sequence