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    Acsl4 acyl-CoA synthetase long-chain family member 4 [ Mus musculus (house mouse) ]

    Gene ID: 50790, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Acsl4provided by MGI
    Official Full Name
    acyl-CoA synthetase long-chain family member 4provided by MGI
    Primary source
    MGI:MGI:1354713
    See related
    Ensembl:ENSMUSG00000031278 AllianceGenome:MGI:1354713
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ACS4; Facl4; Lacs4; 9430020A05Rik
    Summary
    Enables long-chain fatty acid-CoA ligase activity. Acts upstream of or within embryonic process involved in female pregnancy. Located in mitochondrion. Is expressed in several structures, including alimentary system; integumental system; limb mesenchyme; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in intellectual disability and non-syndromic X-linked intellectual disability 63. Orthologous to human ACSL4 (acyl-CoA synthetase long chain family member 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in placenta adult (RPKM 12.0), adrenal adult (RPKM 11.3) and 23 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Acsl4 in Genome Data Viewer
    Location:
    X F2; X 63.12 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (141100989..141173792, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (142317993..142390802, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene Neighboring gene potassium voltage-gated channel subfamily E regulatory subunit 5 Neighboring gene STARR-seq mESC enhancer starr_48018 Neighboring gene peptidylprolyl isomerase A pseudogene x_1100.1 Neighboring gene ribosomal protein L38 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Ferroptosis driven by radical oxidation of n-6 polyunsaturated fatty acids mediates acetaminophen-induced acute liver failure. Yamada N, et al. Cell Death Dis, 2020 Feb 24. PMID 32094346, Free PMC Article
    2. Relationship Between ACSL4-Mediated Ferroptosis and Chronic Obstructive Pulmonary Disease. Wang Y, et al. Int J Chron Obstruct Pulmon Dis, 2023. PMID 36817367, Free PMC Article
    3. ACSL4-dependent ferroptosis does not represent a tumor-suppressive mechanism but ACSL4 rather promotes liver cancer progression. Grube J, et al. Cell Death Dis, 2022 Aug 13. PMID 35963845, Free PMC Article
    4. ACSL4 contributes to ferroptosis-mediated rhabdomyolysis in exertional heat stroke. He S, et al. J Cachexia Sarcopenia Muscle, 2022 Jun. PMID 35243801, Free PMC Article
    5. ACSL4 deficiency confers protection against ferroptosis-mediated acute kidney injury. Wang Y, et al. Redox Biol, 2022 May. PMID 35180475, Free PMC Article

    See all (85) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ACSL4-Mediated Membrane Phospholipid Remodeling Induces Integrin beta1 Activation to Facilitate Triple-Negative Breast Cancer Metastasis.
      Title: ACSL4-Mediated Membrane Phospholipid Remodeling Induces Integrin β1 Activation to Facilitate Triple-Negative Breast Cancer Metastasis.
    2. Long-chain acyl-CoA synthetase-4 regulates endometrial decidualization through a fatty acid beta-oxidation pathway rather than lipid droplet accumulation.
      Title: Long-chain acyl-CoA synthetase-4 regulates endometrial decidualization through a fatty acid β-oxidation pathway rather than lipid droplet accumulation.
    3. Long-chain acyl-CoA synthetase 4-mediated mitochondrial fatty acid metabolism and dendritic cell antigen presentation.
      Title: Long-chain acyl-CoA synthetase 4-mediated mitochondrial fatty acid metabolism and dendritic cell antigen presentation.
    4. Melatonin improves stroke through MDM2-mediated ubiquitination of ACSL4.
      Title: Melatonin improves stroke through MDM2-mediated ubiquitination of ACSL4.
    5. METTL14 depletion ameliorates ferroptosis in severe acute pancreatitis by increasing the N6-methyladenosine modification of ACSL4 and STA1.
      Title: METTL14 depletion ameliorates ferroptosis in severe acute pancreatitis by increasing the N6-methyladenosine modification of ACSL4 and STA1.
    6. Loss of nephric augmenter of liver regeneration facilitates acute kidney injury via ACSL4-mediated ferroptosis.
      Title: Loss of nephric augmenter of liver regeneration facilitates acute kidney injury via ACSL4-mediated ferroptosis.
    7. RBM45 reprograms lipid metabolism promoting hepatocellular carcinoma via Rictor and ACSL1/ACSL4.
      Title: RBM45 reprograms lipid metabolism promoting hepatocellular carcinoma via Rictor and ACSL1/ACSL4.
    8. Methylation Regulation of LPCAT3 Improves Osteoarthritis by Regulating ACSL4 to Inhibit Chondrocyte Ferroptosis.
      Title: Methylation Regulation of LPCAT3 Improves Osteoarthritis by Regulating ACSL4 to Inhibit Chondrocyte Ferroptosis.
    9. ACSL4 inhibition prevents macrophage ferroptosis and alleviates fibrosis in bleomycin-induced systemic sclerosis model.
      Title: ACSL4 inhibition prevents macrophage ferroptosis and alleviates fibrosis in bleomycin-induced systemic sclerosis model.
    10. microRNA-130b-3p Attenuates Septic Cardiomyopathy by Regulating the AMPK/mTOR Signaling Pathways and Directly Targeting ACSL4 against Ferroptosis.
      Title: microRNA-130b-3p Attenuates Septic Cardiomyopathy by Regulating the AMPK/mTOR Signaling Pathways and Directly Targeting ACSL4 against Ferroptosis.
    Submit: New GeneRIF Correction See all GeneRIFs (41)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (6) 
    • Targeted (5)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables arachidonate-CoA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables arachidonate-CoA ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables arachidonate-CoA ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables long-chain fatty acid-CoA ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables long-chain fatty acid-CoA ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables long-chain fatty acid-CoA ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables very long-chain fatty acid-CoA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables very long-chain fatty acid-CoA ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in dendritic spine development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within embryonic process involved in female pregnancy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in fatty acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in fatty acid transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lipid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lipid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in long-chain fatty acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in long-chain fatty acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in long-chain fatty acid metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in long-chain fatty-acyl-CoA biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in long-chain fatty-acyl-CoA metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of prostaglandin secretion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neuron differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of insulin secretion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of insulin secretion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within regulation of fatty acid metabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in triglyceride biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in lipid droplet IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lipid droplet IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lipid droplet ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondria-associated endoplasmic reticulum membrane contact site ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in peroxisomal membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in peroxisome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    long-chain-fatty-acid--CoA ligase 4
    Names
    LACS 4
    arachidonate--CoA ligase
    fatty acid-Coenzyme A ligase, long chain 4
    long-chain acyl-CoA synthetase 4
    mACS4
    NP_001028772.1
    NP_062350.3
    NP_997508.1
    XP_011246144.1
    XP_011246145.1
    XP_030107239.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033600.1 → NP_001028772.1  long-chain-fatty-acid--CoA ligase 4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL731672, BC016416
      Consensus CDS
      CCDS41156.1
      UniProtKB/TrEMBL
      Q8BW44, Q91YN3
      Related
      ENSMUSP00000108524.2, ENSMUST00000112903.8
      Conserved Domains (1) summary
      cd17639
      Location:80 → 655
      LC_FACS_euk1; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS), including fungal proteins

    2. NM_019477.3 → NP_062350.3  long-chain-fatty-acid--CoA ligase 4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AK054387, AL731672
      Consensus CDS
      CCDS41156.1
      UniProtKB/TrEMBL
      Q8BW44, Q91YN3
      Related
      ENSMUSP00000108525.2, ENSMUST00000112904.8
      Conserved Domains (1) summary
      cd17639
      Location:80 → 655
      LC_FACS_euk1; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS), including fungal proteins

    3. NM_207625.2 → NP_997508.1  long-chain-fatty-acid--CoA ligase 4 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AB033886, AL731672, BB857663
      Consensus CDS
      CCDS30448.1
      UniProtKB/Swiss-Prot
      Q5D071, Q9JHT4, Q9QUJ7, Q9R0H3
      UniProtKB/TrEMBL
      Q8BW44
      Related
      ENSMUSP00000033634.5, ENSMUST00000033634.5
      Conserved Domains (1) summary
      cd17639
      Location:121 → 696
      LC_FACS_euk1; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS), including fungal proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      141100989..141173792 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030251379.2 → XP_030107239.1  long-chain-fatty-acid--CoA ligase 4 isoform X1

      UniProtKB/Swiss-Prot
      Q5D071, Q9JHT4, Q9QUJ7, Q9R0H3
      UniProtKB/TrEMBL
      Q8BW44
      Conserved Domains (1) summary
      cd17639
      Location:121 → 696
      LC_FACS_euk1; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS), including fungal proteins

    2. XM_011247843.4 → XP_011246145.1  long-chain-fatty-acid--CoA ligase 4 isoform X2

      UniProtKB/TrEMBL
      Q8BW44, Q91YN3
      Conserved Domains (1) summary
      cd17639
      Location:80 → 655
      LC_FACS_euk1; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS), including fungal proteins

    3. XM_011247842.4 → XP_011246144.1  long-chain-fatty-acid--CoA ligase 4 isoform X2

      UniProtKB/TrEMBL
      Q8BW44, Q91YN3
      Conserved Domains (1) summary
      cd17639
      Location:80 → 655
      LC_FACS_euk1; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS), including fungal proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9QUJ7.2 GenPept UniProtKB/Swiss-Prot:Q9QUJ7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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