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    Pi4kb phosphatidylinositol 4-kinase beta [ Rattus norvegicus (Norway rat) ]

    Gene ID: 81747, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pi4kbprovided by RGD
    Official Full Name
    phosphatidylinositol 4-kinase betaprovided by RGD
    Primary source
    RGD:621214
    See related
    EnsemblRapid:ENSRNOG00000021024 AllianceGenome:RGD:621214
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Pik4cb
    Summary
    Enables 1-phosphatidylinositol 4-kinase activity. Predicted to be involved in inner ear development; phosphatidylinositol phosphate biosynthetic process; and phosphatidylinositol-mediated signaling. Predicted to act upstream of or within lysosome organization. Predicted to be located in Golgi membrane. Predicted to be active in cytoplasm and membrane. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness. Orthologous to human PI4KB (phosphatidylinositol 4-kinase beta). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 175.8), Kidney (RPKM 157.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pi4kb in Genome Data Viewer
    Location:
    2q34
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (185229392..185261697)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (182540377..182572684)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (196139724..196172055)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene selenium binding protein 1 Neighboring gene regulatory factor X5 Neighboring gene uncharacterized LOC102547008 Neighboring gene zinc finger protein 687 Neighboring gene proteasome 26S subunit ubiquitin receptor, non-ATPase 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Sanguinarine suppresses IgE induced inflammatory responses through inhibition of type II PtdIns 4-kinase(s). Bojjireddy N, et al. Arch Biochem Biophys, 2013 Sep 15. PMID 23899475
    2. Sphingosine-1-phosphate formation activates phosphatidylinositol-4 kinase in basolateral membranes from kidney cells: crosstalk in cell signaling through sphingolipids and phospholipids. Einicker-Lamas M, et al. J Biochem, 2003 Oct. PMID 14607979
    3. Cloning and characterization of a 92 kDa soluble phosphatidylinositol 4-kinase. Nakagawa T, et al. Biochem J, 1996 Dec 1. PMID 8973579, Free PMC Article
    4. Functional implication of neuronal calcium sensor-1 and phosphoinositol 4-kinase-beta interaction in regulated exocytosis of PC12 cells. de Barry J, et al. J Biol Chem, 2006 Jun 30. PMID 16638749
    5. Overexpression of kidney phosphatidylinositol 4-kinasebeta and phospholipase C(gamma1) proteins in two rodent models of polycystic kidney disease. Cuozzo FP, et al. Biochim Biophys Acta, 2002 May 21. PMID 12009430

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These results suggest that the anti-inflammatory effects of sanguinarine on PtdIns 3-kinase signaling pathway are more likely an indirect effect and emphasize the importance of the cross talk between type II PtdIns 4-kinases and PtdIns 3-kinases.
      Title: Sanguinarine suppresses IgE induced inflammatory responses through inhibition of type II PtdIns 4-kinase(s).
    2. Work suggests an important role for both eEF1A2 and PI4KIIIbeta in the control of PI(4,5)P(2) signaling and actin remodeling.
      Title: Eukaryotic elongation factor 1A2 cooperates with phosphatidylinositol-4 kinase III beta to stimulate production of filopodia through increased phosphatidylinositol-4,5 bisphosphate generation.
    3. NCS-1 protein and 1-phosphatidylinositol 4-kinase b interact in neuronal cells and are translocated to membranes during nucleotide-evoked exocytosis.
      Title: Neuronal calcium sensor 1 and phosphatidylinositol 4-OH kinase beta interact in neuronal cells and are translocated to membranes during nucleotide-evoked exocytosis.
    4. functional implication of a NCS-1.PI4K-beta complex in regulated exocytosis in neurons
      Title: Functional implication of neuronal calcium sensor-1 and phosphoinositol 4-kinase-beta interaction in regulated exocytosis of PC12 cells.
    5. Overexpression of a PI4K beta mutant in rat mast cells inhibits IgE receptor-triggered phosphatidylinositol 4,5-bisphosphate (PIP2) hydrolysis and exocytosis.
      Title: Neuronal calcium sensor-1 and phosphatidylinositol 4-kinase beta regulate IgE receptor-triggered exocytosis in cultured mast cells.
    6. there is a physical and functional relationship between eEF1A2 and PI4KIIIbeta
      Title: Binding of elongation factor eEF1A2 to phosphatidylinositol 4-kinase beta stimulates lipid kinase activity and phosphatidylinositol 4-phosphate generation.
    7. phosphatidylinositol-4 kinase in basolateral membranes from kidney cells is activated by sphingosine-1-phosphate
      Title: Sphingosine-1-phosphate formation activates phosphatidylinositol-4 kinase in basolateral membranes from kidney cells: crosstalk in cell signaling through sphingolipids and phospholipids.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 1-phosphatidylinositol 4-kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 1-phosphatidylinositol 4-kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 1-phosphatidylinositol 4-kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 1-phosphatidylinositol 4-kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables 1-phosphatidylinositol 4-kinase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables 14-3-3 protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 14-3-3 protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables 14-3-3 protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in inner ear development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in inner ear development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in inner ear development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in inner ear development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in lysosome organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within lysosome organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phosphatidylinositol phosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphatidylinositol phosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phosphatidylinositol-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in rough endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    phosphatidylinositol 4-kinase beta
    Names
    PI4K-beta
    PI4Kbeta
    catalytic phosphatidylinositol 4-kinase beta
    phosphatidylinositol 4-kinase, catalytic, beta polypeptide
    ptdIns 4-kinase beta
    NP_112345.1
    XP_008759555.1
    XP_038959158.1
    XP_038959159.1
    XP_038959160.1
    XP_038959161.1
    XP_038959162.1
    XP_038959163.1
    XP_063138702.1
    XP_063138703.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031083.2 → NP_112345.1  phosphatidylinositol 4-kinase beta

      See identical proteins and their annotated locations for NP_112345.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/Swiss-Prot
      O08561
      UniProtKB/TrEMBL
      A0A8L2QJX4, A6K2T7
      Conserved Domains (2) summary
      cd05168
      Location:529 → 816
      PI4Kc_III_beta; Catalytic domain of Type III Phosphoinositide 4-kinase beta
      cd22246
      Location:2 → 66
      PI4KB_NTD; N-terminal domain of phosphatidylinositol 4-kinase beta

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      185229392..185261697
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039103230.2 → XP_038959158.1  phosphatidylinositol 4-kinase beta isoform X1

      UniProtKB/TrEMBL
      A0A8L2QJX4
      Related
      ENSRNOP00000082231.2, ENSRNOT00000103639.2
      Conserved Domains (2) summary
      cd05168
      Location:554 → 862
      PI4Kc_III_beta; Catalytic domain of Type III Phosphoinositide 4-kinase beta
      cd22246
      Location:27 → 91
      PI4KB_NTD; N-terminal domain of phosphatidylinositol 4-kinase beta

    2. XM_008761333.4 → XP_008759555.1  phosphatidylinositol 4-kinase beta isoform X4

      See identical proteins and their annotated locations for XP_008759555.1

      UniProtKB/TrEMBL
      A0A8I6ALD3, A0A8L2QJX4
      Related
      ENSRNOP00000093461.1, ENSRNOT00000112810.2
      Conserved Domains (1) summary
      cd05168
      Location:554 → 841
      PI4Kc_III_beta; Catalytic domain of Type III Phosphoinositide 4-kinase beta

    3. XM_039103233.2 → XP_038959161.1  phosphatidylinositol 4-kinase beta isoform X3

      UniProtKB/TrEMBL
      A0A0G2JYH1
      Conserved Domains (2) summary
      cd05168
      Location:539 → 847
      PI4Kc_III_beta; Catalytic domain of Type III Phosphoinositide 4-kinase beta
      cd22246
      Location:27 → 91
      PI4KB_NTD; N-terminal domain of phosphatidylinositol 4-kinase beta

    4. XM_039103235.2 → XP_038959163.1  phosphatidylinositol 4-kinase beta isoform X6

      UniProtKB/TrEMBL
      A0A8I5ZT79, A0A8L2QJX4
      Related
      ENSRNOP00000095998.2, ENSRNOT00000112486.2
      Conserved Domains (2) summary
      cd05168
      Location:539 → 826
      PI4Kc_III_beta; Catalytic domain of Type III Phosphoinositide 4-kinase beta
      cd22246
      Location:27 → 91
      PI4KB_NTD; N-terminal domain of phosphatidylinositol 4-kinase beta

    5. XM_039103231.2 → XP_038959159.1  phosphatidylinositol 4-kinase beta isoform X1

      UniProtKB/TrEMBL
      A0A8L2QJX4
      Conserved Domains (2) summary
      cd05168
      Location:554 → 862
      PI4Kc_III_beta; Catalytic domain of Type III Phosphoinositide 4-kinase beta
      cd22246
      Location:27 → 91
      PI4KB_NTD; N-terminal domain of phosphatidylinositol 4-kinase beta

    6. XM_039103232.2 → XP_038959160.1  phosphatidylinositol 4-kinase beta isoform X2

      UniProtKB/TrEMBL
      A0A8L2QJX4
      Related
      ENSRNOP00000089657.2, ENSRNOT00000118319.2
      Conserved Domains (2) summary
      cd05168
      Location:542 → 850
      PI4Kc_III_beta; Catalytic domain of Type III Phosphoinositide 4-kinase beta
      cd22246
      Location:15 → 79
      PI4KB_NTD; N-terminal domain of phosphatidylinositol 4-kinase beta

    7. XM_063282632.1 → XP_063138702.1  phosphatidylinositol 4-kinase beta isoform X7

      UniProtKB/TrEMBL
      A0A8I6ASK5, A0A8L2QJX4

    8. XM_039103234.2 → XP_038959162.1  phosphatidylinositol 4-kinase beta isoform X5

      UniProtKB/TrEMBL
      A0A0G2JYH1, A0A8I6AD21
      Related
      ENSRNOP00000039342.3, ENSRNOT00000040501.4
      Conserved Domains (2) summary
      cd05168
      Location:529 → 837
      PI4Kc_III_beta; Catalytic domain of Type III Phosphoinositide 4-kinase beta
      cd22246
      Location:2 → 66
      PI4KB_NTD; N-terminal domain of phosphatidylinositol 4-kinase beta

    9. XM_063282633.1 → XP_063138703.1  phosphatidylinositol 4-kinase beta isoform X8

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O08561.1 GenPept UniProtKB/Swiss-Prot:O08561

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