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    Hivep2 HIVEP zinc finger 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29721, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Hivep2provided by RGD
    Official Full Name
    HIVEP zinc finger 2provided by RGD
    Primary source
    RGD:61988
    See related
    EnsemblRapid:ENSRNOG00000011015 AllianceGenome:RGD:61988
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    MIBP1
    Summary
    Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 43. Orthologous to human HIVEP2 (HIVEP zinc finger 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 142.9), Thymus (RPKM 109.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Hivep2 in Genome Data Viewer
    Location:
    1p13
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (10176880..10376089)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (8358205..8555993)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (8129354..8333890)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene cofilin 1, pseudogene 8 Neighboring gene uncharacterized LOC134484948 Neighboring gene androgen-induced 1 Neighboring gene ribosomal protein L13A, pseudogene 9 Neighboring gene transfer RNA alanine (anticodon AGC) 27 Neighboring gene similar to human chromosome 3 open reading frame 38

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Cloning and characterization of a c-myc intron binding protein (MIBP1). Makino R, et al. Nucleic Acids Res, 1994 Dec 25. PMID 7838722, Free PMC Article
    2. Angiotensinogen gene-inducible enhancer-binding protein 1, a member of a new family of large nuclear proteins that recognize nuclear factor kappa B-binding sites through a zinc finger motif. Ron D, et al. Mol Cell Biol, 1991 May. PMID 2017183, Free PMC Article
    3. Activation of somatostatin receptor II expression by transcription factors MIBP1 and SEF-2 in the murine brain. Dörflinger U, et al. Mol Cell Biol, 1999 May. PMID 10207097, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    human immunodeficiency virus type I enhancer-binding protein 2 homolog
    Names
    DNA-binding protein AGIE-BP1
    MIBP-1
    angiotensinogen gene-inducible enhancer-binding protein 1
    c-myc intron binding protein 1
    human immunodeficiency virus type 1 enhancer-binding protein 2
    human immunodeficiency virus type I enhancer binding protein 2
    myc intron-binding protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_024137.1 → NP_077051.1  human immunodeficiency virus type I enhancer-binding protein 2 homolog

      See identical proteins and their annotated locations for NP_077051.1

      Status: PROVISIONAL

      Source sequence(s)
      D37951
      UniProtKB/Swiss-Prot
      Q00900, Q63725
      Related
      ENSRNOP00000015131.2, ENSRNOT00000015131.6
      Conserved Domains (5) summary
      sd00017
      Location:191 → 211
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:1792 → 1812
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00020
      Location:1843 → 1877
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:1790 → 1812
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:204 → 228
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      10176880..10376089
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039109867.2 → XP_038965795.1  human immunodeficiency virus type I enhancer-binding protein 2 homolog isoform X1

      UniProtKB/TrEMBL
      A6JP69, G3V7H8
      Conserved Domains (8) summary
      PTZ00449
      Location:2024 → 2167
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      PTZ00441
      Location:824 → 935
      PTZ00441; sporozoite surface protein 2 (SSP2); Provisional
      sd00017
      Location:191 → 211
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:1792 → 1812
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00020
      Location:1843 → 1877
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:1790 → 1812
      zf-C2H2; Zinc finger, C2H2 type
      pfam12171
      Location:1818 → 1842
      zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
      pfam13465
      Location:204 → 228
      zf-H2C2_2; Zinc-finger double domain

    2. XM_063287903.1 → XP_063143973.1  human immunodeficiency virus type I enhancer-binding protein 2 homolog isoform X1

      UniProtKB/TrEMBL
      A6JP69, G3V7H8

    3. XM_039109863.2 → XP_038965791.1  human immunodeficiency virus type I enhancer-binding protein 2 homolog isoform X1

      UniProtKB/TrEMBL
      A6JP69, G3V7H8
      Conserved Domains (8) summary
      PTZ00449
      Location:2024 → 2167
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      PTZ00441
      Location:824 → 935
      PTZ00441; sporozoite surface protein 2 (SSP2); Provisional
      sd00017
      Location:191 → 211
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:1792 → 1812
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00020
      Location:1843 → 1877
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:1790 → 1812
      zf-C2H2; Zinc finger, C2H2 type
      pfam12171
      Location:1818 → 1842
      zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
      pfam13465
      Location:204 → 228
      zf-H2C2_2; Zinc-finger double domain

    4. XM_039109870.2 → XP_038965798.1  human immunodeficiency virus type I enhancer-binding protein 2 homolog isoform X1

      UniProtKB/TrEMBL
      A6JP69, G3V7H8
      Conserved Domains (8) summary
      PTZ00449
      Location:2024 → 2167
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      PTZ00441
      Location:824 → 935
      PTZ00441; sporozoite surface protein 2 (SSP2); Provisional
      sd00017
      Location:191 → 211
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:1792 → 1812
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00020
      Location:1843 → 1877
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:1790 → 1812
      zf-C2H2; Zinc finger, C2H2 type
      pfam12171
      Location:1818 → 1842
      zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
      pfam13465
      Location:204 → 228
      zf-H2C2_2; Zinc-finger double domain

    5. XM_039109882.2 → XP_038965810.1  human immunodeficiency virus type I enhancer-binding protein 2 homolog isoform X1

      UniProtKB/TrEMBL
      A6JP69, G3V7H8
      Conserved Domains (8) summary
      PTZ00449
      Location:2024 → 2167
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      PTZ00441
      Location:824 → 935
      PTZ00441; sporozoite surface protein 2 (SSP2); Provisional
      sd00017
      Location:191 → 211
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:1792 → 1812
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00020
      Location:1843 → 1877
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:1790 → 1812
      zf-C2H2; Zinc finger, C2H2 type
      pfam12171
      Location:1818 → 1842
      zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
      pfam13465
      Location:204 → 228
      zf-H2C2_2; Zinc-finger double domain

    6. XM_039109890.2 → XP_038965818.1  human immunodeficiency virus type I enhancer-binding protein 2 homolog isoform X1

      UniProtKB/TrEMBL
      A6JP69, G3V7H8
      Conserved Domains (8) summary
      PTZ00449
      Location:2024 → 2167
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      PTZ00441
      Location:824 → 935
      PTZ00441; sporozoite surface protein 2 (SSP2); Provisional
      sd00017
      Location:191 → 211
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:1792 → 1812
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00020
      Location:1843 → 1877
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:1790 → 1812
      zf-C2H2; Zinc finger, C2H2 type
      pfam12171
      Location:1818 → 1842
      zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
      pfam13465
      Location:204 → 228
      zf-H2C2_2; Zinc-finger double domain

    7. XM_039109872.2 → XP_038965800.1  human immunodeficiency virus type I enhancer-binding protein 2 homolog isoform X1

      UniProtKB/TrEMBL
      A6JP69, G3V7H8
      Conserved Domains (8) summary
      PTZ00449
      Location:2024 → 2167
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      PTZ00441
      Location:824 → 935
      PTZ00441; sporozoite surface protein 2 (SSP2); Provisional
      sd00017
      Location:191 → 211
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:1792 → 1812
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00020
      Location:1843 → 1877
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:1790 → 1812
      zf-C2H2; Zinc finger, C2H2 type
      pfam12171
      Location:1818 → 1842
      zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
      pfam13465
      Location:204 → 228
      zf-H2C2_2; Zinc-finger double domain

    8. XM_063287906.1 → XP_063143976.1  human immunodeficiency virus type I enhancer-binding protein 2 homolog isoform X1

      UniProtKB/TrEMBL
      A6JP69, G3V7H8

    9. XM_039109885.2 → XP_038965813.1  human immunodeficiency virus type I enhancer-binding protein 2 homolog isoform X1

      UniProtKB/TrEMBL
      A6JP69, G3V7H8
      Conserved Domains (8) summary
      PTZ00449
      Location:2024 → 2167
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      PTZ00441
      Location:824 → 935
      PTZ00441; sporozoite surface protein 2 (SSP2); Provisional
      sd00017
      Location:191 → 211
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:1792 → 1812
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00020
      Location:1843 → 1877
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:1790 → 1812
      zf-C2H2; Zinc finger, C2H2 type
      pfam12171
      Location:1818 → 1842
      zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
      pfam13465
      Location:204 → 228
      zf-H2C2_2; Zinc-finger double domain

    10. XM_063287884.1 → XP_063143954.1  human immunodeficiency virus type I enhancer-binding protein 2 homolog isoform X1

      UniProtKB/TrEMBL
      A6JP69, G3V7H8
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q00900.2 GenPept UniProtKB/Swiss-Prot:Q00900

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