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    Rnf43 ring finger protein 43 [ Mus musculus (house mouse) ]

    Gene ID: 207742, updated on 9-Dec-2024

    Summary

    Official Symbol
    Rnf43provided by MGI
    Official Full Name
    ring finger protein 43provided by MGI
    Primary source
    MGI:MGI:2442609
    See related
    Ensembl:ENSMUSG00000034177 AllianceGenome:MGI:2442609
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4732452J19Rik
    Summary
    Predicted to enable frizzled binding activity and ubiquitin protein ligase activity. Involved in negative regulation of Wnt signaling pathway and stem cell proliferation. Predicted to be located in endoplasmic reticulum membrane and nuclear envelope. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; forelimb epidermis; genitourinary system; lung; and submandibular gland primordium. Human ortholog(s) of this gene implicated in endometrial cancer; gastrointestinal system cancer (multiple); irritable bowel syndrome; lung adenocarcinoma; and villous adenoma. Orthologous to human RNF43 (ring finger protein 43). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in duodenum adult (RPKM 7.3), colon adult (RPKM 5.7) and 19 other tissues See more
    Orthologs
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    Genomic context

    See Rnf43 in Genome Data Viewer
    Location:
    11 C; 11 52.17 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (87553913..87626365)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (87663087..87735539)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E68 Neighboring gene STARR-seq mESC enhancer starr_30293 Neighboring gene myotubularin related protein 4 Neighboring gene heat shock transcription factor family member 5 Neighboring gene STARR-positive B cell enhancer ABC_E5260 Neighboring gene STARR-seq mESC enhancer starr_30296 Neighboring gene RIKEN cDNA 1110028F11 gene Neighboring gene predicted gene, 25968 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:87534506-87534735 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:87539623-87539928 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:87547776-87547885 Neighboring gene STARR-positive B cell enhancer ABC_E7039 Neighboring gene STARR-positive B cell enhancer ABC_E1838 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:87563093-87563276 Neighboring gene SPT4A, DSIF elongation factor subunit Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:87565164-87565417 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:87568144-87568342 Neighboring gene STARR-positive B cell enhancer ABC_E8440 Neighboring gene microRNA 142b Neighboring gene microRNA 142

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables frizzled binding  
    enables frizzled binding  
    enables frizzled binding  
    enables metal ion binding  
    enables protein binding PubMed 
    enables ubiquitin protein ligase activity  
    enables ubiquitin-protein transferase activity  
    enables ubiquitin-protein transferase activity  
    Process Evidence Code Pubs
    involved_in Wnt receptor catabolic process  
    involved_in Wnt receptor catabolic process  
    involved_in Wnt receptor catabolic process  
    involved_in Wnt signaling pathway  
    involved_in negative regulation of Wnt signaling pathway PubMed 
    involved_in negative regulation of Wnt signaling pathway  
    involved_in negative regulation of Wnt signaling pathway  
    involved_in protein ubiquitination  
    involved_in protein ubiquitination  
    involved_in protein ubiquitination  
    involved_in stem cell proliferation PubMed 
    involved_in ubiquitin-dependent protein catabolic process  
    involved_in ubiquitin-dependent protein catabolic process  
    involved_in ubiquitin-dependent protein catabolic process  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane  
    located_in nuclear envelope  
    is_active_in plasma membrane  
    located_in plasma membrane  
    located_in plasma membrane  

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase RNF43
    Names
    RING-type E3 ubiquitin transferase RNF43
    NP_001350366.1
    NP_766036.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001363437.1NP_001350366.1  E3 ubiquitin-protein ligase RNF43 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AK028750, AL604022
      Consensus CDS
      CCDS88216.1
      UniProtKB/TrEMBL
      A3KMI3, E9PWJ5
      Related
      ENSMUSP00000044241.5, ENSMUST00000040089.5
      Conserved Domains (2) summary
      cd16798
      Location:143189
      RING-H2_RNF43; RING finger, H2 subclass, found in RING finger protein 43 (RNF43) and similar proteins
      cl28271
      Location:472629
      dnaA; chromosomal replication initiation protein; Provisional
    2. NM_172448.4NP_766036.2  E3 ubiquitin-protein ligase RNF43 isoform 1 precursor

      See identical proteins and their annotated locations for NP_766036.2

      Status: VALIDATED

      Source sequence(s)
      AK032782, BC131957, CF747567
      Consensus CDS
      CCDS25215.2
      UniProtKB/Swiss-Prot
      B2KGH3, Q5NCP0, Q6DI76, Q8BME0, Q8C191, Q8K0X4
      UniProtKB/TrEMBL
      E9PWJ5
      Related
      ENSMUSP00000130685.2, ENSMUST00000165679.8
      Conserved Domains (1) summary
      pfam13639
      Location:270312
      zf-RING_2; Ring finger domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      87553913..87626365
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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