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    Ufsp2 UFM1-specific peptidase 2 [ Mus musculus (house mouse) ]

    Gene ID: 192169, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ufsp2provided by MGI
    Official Full Name
    UFM1-specific peptidase 2provided by MGI
    Primary source
    MGI:MGI:1913679
    See related
    Ensembl:ENSMUSG00000031634 AllianceGenome:MGI:1913679
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1810047C23Rik
    Summary
    Enables deUFMylase activity. Involved in regulation of type II interferon production. Located in endoplasmic reticulum and nucleus. Is expressed in liver; orbito-sphenoid; pancreas epithelium; and turbinate bone primordium. Human ortholog(s) of this gene implicated in Beukes hip dysplasia and developmental and epileptic encephalopathy 106. Orthologous to human UFSP2 (UFM1 specific peptidase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in placenta adult (RPKM 16.2), bladder adult (RPKM 14.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ufsp2 in Genome Data Viewer
    Location:
    8 B1.1; 8 25.96 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (46428551..46449995)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (45975515..45996958)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene PDZ and LIM domain 3 Neighboring gene STARR-seq mESC enhancer starr_21375 Neighboring gene STARR-positive B cell enhancer mm9_chr8:47020100-47020401 Neighboring gene coiled-coil domain containing 110 Neighboring gene cilia and flagella associated protein 96 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:47060555-47060664 Neighboring gene STARR-positive B cell enhancer ABC_E10496 Neighboring gene ankyrin repeat domain 37 Neighboring gene Lrp2 binding protein Neighboring gene sorting nexin 25 Neighboring gene STARR-seq mESC enhancer starr_21377 Neighboring gene STARR-positive B cell enhancer ABC_E10497 Neighboring gene predicted gene 15634

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structure of ubiquitin-fold modifier 1-specific protease UfSP2. Ha BH, et al. J Biol Chem, 2011 Mar 25. PMID 21228277, Free PMC Article
    2. Structural basis for Ufm1 processing by UfSP1. Ha BH, et al. J Biol Chem, 2008 May 23. PMID 18321862
    3. UFMylation inhibits the proinflammatory capacity of interferon-γ-activated macrophages. Balce DR, et al. Proc Natl Acad Sci U S A, 2021 Jan 5. PMID 33372156, Free PMC Article
    4. Two novel ubiquitin-fold modifier 1 (Ufm1)-specific proteases, UfSP1 and UfSP2. Kang SH, et al. J Biol Chem, 2007 Feb 23. PMID 17182609
    5. CDK5RAP3, a UFL1 substrate adaptor, is crucial for liver development. Yang R, et al. Development, 2019 Jan 25. PMID 30635284

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Structure of ubiquitin-fold modifier 1-specific protease UfSP2.
      Title: Structure of ubiquitin-fold modifier 1-specific protease UfSP2.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • MGC7482

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables deUFMylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables deUFMylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables deUFMylase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables deUFMylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of proteolysis involved in protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of intracellular estrogen receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of intracellular estrogen receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of type II interferon production IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in rescue of stalled ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ribosome disassembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ribosome disassembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ufm1-specific protease 2
    NP_619609.1
    XP_006509372.1
    XP_017168107.1
    XP_036009725.1
    XP_036009726.1
    XP_036009727.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_138668.2 → NP_619609.1  ufm1-specific protease 2

      See identical proteins and their annotated locations for NP_619609.1

      Status: VALIDATED

      Source sequence(s)
      AC114558, AK075795, AK078309
      Consensus CDS
      CCDS22284.1
      UniProtKB/Swiss-Prot
      Q8C5I0, Q99K23
      Related
      ENSMUSP00000034051.7, ENSMUST00000034051.7
      Conserved Domains (1) summary
      pfam07910
      Location:272 → 453
      Peptidase_C78; Peptidase family C78

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      46428551..46449995
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017312618.3 → XP_017168107.1  ufm1-specific protease 2 isoform X1

      UniProtKB/Swiss-Prot
      Q8C5I0, Q99K23
      Conserved Domains (1) summary
      pfam07910
      Location:272 → 453
      Peptidase_C78; Peptidase family C78

    2. XM_036153833.1 → XP_036009726.1  ufm1-specific protease 2 isoform X3

      Conserved Domains (1) summary
      pfam07910
      Location:93 → 274
      Peptidase_C78; Peptidase family C78

    3. XM_006509309.3 → XP_006509372.1  ufm1-specific protease 2 isoform X2

      Conserved Domains (1) summary
      pfam07910
      Location:161 → 342
      Peptidase_C78; Peptidase family C78

    4. XM_036153834.1 → XP_036009727.1  ufm1-specific protease 2 isoform X3

      Conserved Domains (1) summary
      pfam07910
      Location:93 → 274
      Peptidase_C78; Peptidase family C78

    5. XM_036153832.1 → XP_036009725.1  ufm1-specific protease 2 isoform X2

      Conserved Domains (1) summary
      pfam07910
      Location:161 → 342
      Peptidase_C78; Peptidase family C78
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99K23.1 GenPept UniProtKB/Swiss-Prot:Q99K23

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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