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    Decr2 2,4-dienoyl-CoA reductase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 64461, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Decr2provided by RGD
    Official Full Name
    2,4-dienoyl-CoA reductase 2provided by RGD
    Primary source
    RGD:71002
    See related
    EnsemblRapid:ENSRNOG00000088984 AllianceGenome:RGD:71002
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Dcrakl; putativeperoxisomal24-dienoyl-CoAreductase
    Summary
    Enables 2,4-dienoyl-CoA reductase (NADPH) activity. Predicted to be involved in unsaturated fatty acid biosynthetic process. Located in peroxisomal membrane. Orthologous to human DECR2 (2,4-dienoyl-CoA reductase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 808.8), Liver (RPKM 482.1) and 3 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Decr2 in Genome Data Viewer
    Location:
    10q12
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (15609389..15617779, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (15104907..15113281, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (15451850..15460227, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene RAB11 family interacting protein 3 Neighboring gene ribosomal protein L37A, pseudogene 10 Neighboring gene ribosomal protein L3, pseudogene 2 Neighboring gene 60S ribosomal protein L34-like Neighboring gene NME/NM23 nucleoside diphosphate kinase 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Characterisation of human peroxisomal 2,4-dienoyl-CoA reductase. De Nys K, et al. Biochim Biophys Acta, 2001 Aug 29. PMID 11514237
    2. Identification of peroxisomal proteins by using M13 phage protein VI phage display: molecular evidence that mammalian peroxisomes contain a 2,4-dienoyl-CoA reductase. Fransen M, et al. Biochem J, 1999 Jun 1. PMID 10333503, Free PMC Article
    3. Molecular cloning and expression of mammalian peroxisomal trans-2-enoyl-coenzyme A reductase cDNAs. Das AK, et al. J Biol Chem, 2000 Aug 11. PMID 10811639
    4. Identification of a novel human peroxisomal 2,4-dienoyl-CoA reductase related protein using the M13 phage protein VI phage display technology. Amery L, et al. Comb Chem High Throughput Screen, 2001 Nov. PMID 11669066
    5. Proteomic analysis of rat liver peroxisome: presence of peroxisome-specific isozyme of Lon protease. Kikuchi M, et al. J Biol Chem, 2004 Jan 2. PMID 14561759

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 2,4-dienoyl-CoA reductase (NADPH) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 2,4-dienoyl-CoA reductase (NADPH) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 2,4-dienoyl-CoA reductase (NADPH) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 2,4-dienoyl-CoA reductase (NADPH) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleoside diphosphate kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables trans-2-enoyl-CoA reductase (NADPH) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in CTP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in GTP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in UTP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fatty acid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fatty acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in unsaturated fatty acid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in peroxisomal membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in peroxisome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in peroxisome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    peroxisomal 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing]
    Names
    2,4-dienoyl CoA reductase 2, peroxisomal
    2-4-dienoyl-Coenzyme A reductase 2, peroxisomal
    DCR-AKL
    pVI-AKL
    peroxisomal 2,4-dienoyl-CoA reductase
    putative peroxisomal 2,4-dienoyl-CoA reductase
    putative peroxisomal 24-dienoyl-CoA reductase
    NP_741993.1
    XP_006246086.1
    XP_038942721.1
    XP_038942722.1
    XP_038942723.1
    XP_063125886.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_171996.3 → NP_741993.1  peroxisomal 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing]

      See identical proteins and their annotated locations for NP_741993.1

      Status: PROVISIONAL

      Source sequence(s)
      BC070959
      UniProtKB/Swiss-Prot
      Q9Z2M4
      UniProtKB/TrEMBL
      A0A8I6AJE6, A6HD86
      Related
      ENSRNOP00000027518.5, ENSRNOT00000027518.7
      Conserved Domains (1) summary
      cd05369
      Location:26 → 273
      TER_DECR_SDR_a; Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      15609389..15617779 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006246024.5 → XP_006246086.1  peroxisomal 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing] isoform X1

      See identical proteins and their annotated locations for XP_006246086.1

      UniProtKB/Swiss-Prot
      Q9Z2M4
      UniProtKB/TrEMBL
      A0A8I6AJE6, A6HD86
      Conserved Domains (1) summary
      cd05369
      Location:26 → 273
      TER_DECR_SDR_a; Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR

    2. XM_039086793.2 → XP_038942721.1  peroxisomal 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing] isoform X1

      UniProtKB/Swiss-Prot
      Q9Z2M4
      UniProtKB/TrEMBL
      A0A8I6AJE6, A6HD86
      Conserved Domains (1) summary
      cd05369
      Location:26 → 273
      TER_DECR_SDR_a; Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR

    3. XM_063269816.1 → XP_063125886.1  peroxisomal 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing] isoform X1

      UniProtKB/Swiss-Prot
      Q9Z2M4
      UniProtKB/TrEMBL
      A0A8I6AJE6, A6HD86

    4. XM_039086795.2 → XP_038942723.1  peroxisomal 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing] isoform X2

      Conserved Domains (1) summary
      cl21454
      Location:26 → 200
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    5. XM_039086794.2 → XP_038942722.1  peroxisomal 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing] isoform X2

      Conserved Domains (1) summary
      cl21454
      Location:26 → 200
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Z2M4.1 GenPept UniProtKB/Swiss-Prot:Q9Z2M4

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