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    Ddx59 DEAD box helicase 59 [ Mus musculus (house mouse) ]

    Gene ID: 67997, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Ddx59provided by MGI
    Official Full Name
    DEAD box helicase 59provided by MGI
    Primary source
    MGI:MGI:1915247
    See related
    Ensembl:ENSMUSG00000026404 AllianceGenome:MGI:1915247
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1210002B07Rik; 4833411G06Rik
    Summary
    Predicted to enable RNA helicase activity and mRNA binding activity. Predicted to be involved in chromatin looping and chromatin remodeling. Predicted to be located in cytoplasm and nucleus. Is expressed in several structures, including early conceptus; eye; face; lip; and oocyte. Human ortholog(s) of this gene implicated in orofaciodigital syndrome V. Orthologous to human DDX59 (DEAD-box helicase 59). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 2.8), CNS E14 (RPKM 2.5) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ddx59 in Genome Data Viewer
    Location:
    1 E4; 1 59.73 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (136343009..136384019)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (136415271..136456192)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene calmodulin regulated spectrin-associated protein family, member 2 Neighboring gene G protein-coupled receptor 25 Neighboring gene RIKEN cDNA 9230116N13 gene Neighboring gene STARR-seq mESC enhancer starr_02406 Neighboring gene STARR-positive B cell enhancer ABC_E993 Neighboring gene kinesin family member 14 Neighboring gene predicted gene 29485 Neighboring gene STARR-positive B cell enhancer mm9_chr1:138447476-138447776 Neighboring gene STARR-seq mESC enhancer starr_02411 Neighboring gene STARR-seq mESC enhancer starr_02413 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:138476081-138476290 Neighboring gene STARR-positive B cell enhancer ABC_E145 Neighboring gene STARR-seq mESC enhancer starr_02418 Neighboring gene STARR-positive B cell enhancer ABC_E5807 Neighboring gene STARR-positive B cell enhancer mm9_chr1:138521286-138521587 Neighboring gene zinc finger protein 281

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mutations in DDX59 implicate RNA helicase in the pathogenesis of orofaciodigital syndrome. Shamseldin HE, et al. Am J Hum Genet, 2013 Sep 5. PMID 23972372, Free PMC Article
    2. Brn3a and Nurr1 mediate a gene regulatory pathway for habenula development. Quina LA, et al. J Neurosci, 2009 Nov 11. PMID 19906978, Free PMC Article
    3. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    5. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These data strongly implicate DDX59 RNA helicase family member in the pathogenesis of orofaciodigital syndrome.
      Title: Mutations in DDX59 implicate RNA helicase in the pathogenesis of orofaciodigital syndrome.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent H2AZ histone chaperone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent H3-H4 histone complex chaperone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA clamp loader activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chromatin extrusion motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cohesin loader activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin looping IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    probable ATP-dependent RNA helicase DDX59
    Names
    DEAD (Asp-Glu-Ala-Asp) box polypeptide 59
    DEAD box protein 59
    zinc finger HIT domain-containing protein 5
    NP_080776.1
    XP_006529905.1
    XP_006529906.1
    XP_006529907.1
    XP_036009140.1
    XP_036009142.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026500.3 → NP_080776.1  probable ATP-dependent RNA helicase DDX59

      See identical proteins and their annotated locations for NP_080776.1

      Status: VALIDATED

      Source sequence(s)
      AK004833, AK133731
      Consensus CDS
      CCDS15326.1
      UniProtKB/Swiss-Prot
      Q8C667, Q9CSD1, Q9DBN9
      Related
      ENSMUSP00000027655.7, ENSMUST00000027655.8
      Conserved Domains (1) summary
      PLN00206
      Location:70 → 593
      PLN00206; DEAD-box ATP-dependent RNA helicase; Provisional

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      136343009..136384019
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036153247.1 → XP_036009140.1  probable ATP-dependent RNA helicase DDX59 isoform X1

      Conserved Domains (1) summary
      PLN00206
      Location:70 → 563
      PLN00206; DEAD-box ATP-dependent RNA helicase; Provisional

    2. XM_006529844.5 → XP_006529907.1  probable ATP-dependent RNA helicase DDX59 isoform X4

      Conserved Domains (1) summary
      PLN00206
      Location:70 → 532
      PLN00206; DEAD-box ATP-dependent RNA helicase; Provisional

    3. XM_006529842.5 → XP_006529905.1  probable ATP-dependent RNA helicase DDX59 isoform X2

      Conserved Domains (1) summary
      PLN00206
      Location:70 → 532
      PLN00206; DEAD-box ATP-dependent RNA helicase; Provisional

    4. XM_006529843.4 → XP_006529906.1  probable ATP-dependent RNA helicase DDX59 isoform X3

      Conserved Domains (1) summary
      PLN00206
      Location:70 → 550
      PLN00206; DEAD-box ATP-dependent RNA helicase; Provisional

    5. XM_036153249.1 → XP_036009142.1  probable ATP-dependent RNA helicase DDX59 isoform X5

      Conserved Domains (1) summary
      PLN00206
      Location:70 → 520
      PLN00206; DEAD-box ATP-dependent RNA helicase; Provisional

    RNA

    1. XR_004934150.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_178052.3: Suppressed sequence

      Description
      NM_178052.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9DBN9.1 GenPept UniProtKB/Swiss-Prot:Q9DBN9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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