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    Exoc6 exocyst complex component 6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 50556, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Exoc6provided by RGD
    Official Full Name
    exocyst complex component 6provided by RGD
    Primary source
    RGD:3653
    See related
    EnsemblRapid:ENSRNOG00000036601 AllianceGenome:RGD:3653
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Sec15; Sec15l1
    Summary
    Predicted to be involved in Golgi to plasma membrane transport and exocytosis. Predicted to act upstream of or within erythrocyte differentiation. Predicted to be located in Flemming body; growth cone; and perinuclear region of cytoplasm. Predicted to be part of exocyst. Orthologous to human EXOC6 (exocyst complex component 6). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 139.7), Spleen (RPKM 93.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Exoc6 in Genome Data Viewer
    Location:
    1q53
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (244727084..244870263)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (235314612..235457824)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (256211879..256369318)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134483991 Neighboring gene hematopoietically expressed homeobox Neighboring gene cytochrome P450, family 26, subfamily C, polypeptide 1 Neighboring gene cytochrome P450, family 26, subfamily a, polypeptide 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Hemoglobin deficit: an inherited hypochromic anemia in the mouse. Bannerman RM, et al. Proc Soc Exp Biol Med, 1986 May. PMID 3960859
    2. Subunit structure of the mammalian exocyst complex. Kee Y, et al. Proc Natl Acad Sci U S A, 1997 Dec 23. PMID 9405631, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in Golgi to plasma membrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within erythrocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle tethering involved in exocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Flemming body IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of exocyst IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of exocyst IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in growth cone IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    exocyst complex component 6
    Names
    SEC15-like 1
    SEC15-like protein 1
    exocyst complex component Sec15A
    rSec15

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019277.2 → NP_062150.2  exocyst complex component 6

      See identical proteins and their annotated locations for NP_062150.2

      Status: VALIDATED

      Source sequence(s)
      AF032668
      UniProtKB/Swiss-Prot
      O54923
      UniProtKB/TrEMBL
      A6I171, F1M0F4
      Related
      ENSRNOP00000092314.2, ENSRNOT00000115437.2
      Conserved Domains (1) summary
      pfam04091
      Location:456 → 762
      Sec15; Exocyst complex subunit Sec15-like

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      244727084..244870263
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039088459.2 → XP_038944387.1  exocyst complex component 6 isoform X1

      UniProtKB/TrEMBL
      A6I171, F1M0F4
      Conserved Domains (1) summary
      pfam04091
      Location:307 → 613
      Sec15; Exocyst complex subunit Sec15-like
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O54923.2 GenPept UniProtKB/Swiss-Prot:O54923

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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