Trpv1 transient receptor potential cation channel, subfamily V, member 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Trpv1provided by RGD
Official Full Name: transient receptor potential cation channel, subfamily V, member 1provided by RGD
Primary source: RGD:628841
See related: EnsemblRapid:ENSRNOG00000019486 AllianceGenome:RGD:628841
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Vr1; Vr1l1; VR.5'sv; TRPV1_SON
Summary: Enables several functions, including ATP binding activity; calmodulin binding activity; and ligand-gated monoatomic ion channel activity. Involved in several processes, including calcium ion import across plasma membrane; cellular response to temperature stimulus; and negative regulation of establishment of blood-brain barrier. Acts upstream of or within response to heat and response to pH. Located in dendrite; external side of plasma membrane; and neuronal cell body. Is active in postsynaptic membrane. Used to study myocardial infarction and reflex epilepsy. Human ortholog(s) of this gene implicated in migraine. Orthologous to human TRPV1 (transient receptor potential cation channel subfamily V member 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 50.2), Adrenal (RPKM 8.5) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q24

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (58349936..58375021)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (57851428..57876513)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (59799123..59824208)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TRPV1 corneal neuralgia mutation: Enhanced pH response, bradykinin sensitization, and capsaicin desensitization.
Title: TRPV1 corneal neuralgia mutation: Enhanced pH response, bradykinin sensitization, and capsaicin desensitization.
Ammonium chloride-induced hypothermia is attenuated by transient receptor potential channel vanilloid-1, but augmented by ankyrin-1 in rodents.
Title: Ammonium chloride-induced hypothermia is attenuated by transient receptor potential channel vanilloid-1, but augmented by ankyrin-1 in rodents.
Low-Level miR-199 Contribute to Neuropathic Low Back Pain via TRPV1 by Regulating the Production of Pro-Inflammatory Cytokines on Macrophage.
Title: Low-Level miR-199 Contribute to Neuropathic Low Back Pain via TRPV1 by Regulating the Production of Pro-Inflammatory Cytokines on Macrophage.
Functional knockout of the TRPV1 channel has no effect on the exercise pressor reflex in rats.
Title: Functional knockout of the TRPV1 channel has no effect on the exercise pressor reflex in rats.
TRPV1 Channels Are New Players in the Reticulum-Mitochondria Ca[2+] Coupling in a Rat Cardiomyoblast Cell Line.
Title: TRPV1 Channels Are New Players in the Reticulum-Mitochondria Ca(2+) Coupling in a Rat Cardiomyoblast Cell Line.
Rutaecarpine ameliorates cardiomyocyte injury induced by high glucose by promoting TRPV1-mediated autophagy.
Title: Rutaecarpine ameliorates cardiomyocyte injury induced by high glucose by promoting TRPV1-mediated autophagy.
Changes in TRPV1 Receptor, CGRP, and BDNF Expression in Rat Dorsal Root Ganglion with Resiniferatoxin-Induced Neuropathic Pain: Modulation by Pulsed Radiofrequency Applied to the Sciatic Nerve.
Title: Changes in TRPV1 Receptor, CGRP, and BDNF Expression in Rat Dorsal Root Ganglion with Resiniferatoxin-Induced Neuropathic Pain: Modulation by Pulsed Radiofrequency Applied to the Sciatic Nerve.
Vacuolar-ATPase-mediated muscle acidification caused muscular mechanical nociceptive hypersensitivity after chronic stress in rats, which involved extracellular matrix proteoglycan and ASIC3.
Title: Vacuolar-ATPase-mediated muscle acidification caused muscular mechanical nociceptive hypersensitivity after chronic stress in rats, which involved extracellular matrix proteoglycan and ASIC3.
The Vanilloid (Capsaicin) Receptor TRPV1 in Blood Pressure Regulation: A Novel Therapeutic Target in Hypertension?
Title: The Vanilloid (Capsaicin) Receptor TRPV1 in Blood Pressure Regulation: A Novel Therapeutic Target in Hypertension?
Opening of capsaicin receptor TRPV1 is stabilized equally by its four subunits.
Title: Opening of capsaicin receptor TRPV1 is stabilized equally by its four subunits.

Submit: New GeneRIF Correction See all GeneRIFs (471)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH127973 (e-PCR)
- UniSTS:211283

AU026955 (e-PCR)
- UniSTS:113771

PMC16295P1 (e-PCR)
- UniSTS:271475

PMC126639P1 (e-PCR)
- UniSTS:270550

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IDA Inferred from Direct Assay more info	PubMed
enables calcium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables calcium channel activity	IDA Inferred from Direct Assay more info	PubMed
enables calcium channel activity	ISO Inferred from Sequence Orthology more info
enables calmodulin binding	IDA Inferred from Direct Assay more info	PubMed
enables chloride channel regulator activity	IDA Inferred from Direct Assay more info	PubMed
enables excitatory extracellular ligand-gated monoatomic ion channel activity	IDA Inferred from Direct Assay more info	PubMed
enables extracellular ligand-gated monoatomic ion channel activity	IDA Inferred from Direct Assay more info	PubMed
enables extracellular ligand-gated monoatomic ion channel activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables intracellularly gated calcium channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables ligand-gated monoatomic ion channel activity	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables monoatomic cation channel activity	IDA Inferred from Direct Assay more info	PubMed
enables monoatomic cation transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylinositol binding	IDA Inferred from Direct Assay more info	PubMed
enables phosphoprotein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables temperature-gated ion channel activity	ISO Inferred from Sequence Orthology more info
enables transmembrane signaling receptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within behavioral response to pain	ISO Inferred from Sequence Orthology more info
involved_in calcium ion import across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in calcium ion import across plasma membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in calcium ion import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in calcium ion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in calcium ion transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in calcium ion transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within calcium ion transport	ISO Inferred from Sequence Orthology more info
involved_in calcium-mediated signaling	IEA Inferred from Electronic Annotation more info
involved_in cellular response to ATP	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to acidic pH	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to acidic pH	ISO Inferred from Sequence Orthology more info
involved_in cellular response to alkaloid	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to cytokine stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to growth factor stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to heat	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to heat	ISO Inferred from Sequence Orthology more info
involved_in cellular response to nerve growth factor stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to temperature stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to tumor necrosis factor	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within detection of chemical stimulus involved in sensory perception of pain	ISO Inferred from Sequence Orthology more info
involved_in detection of temperature stimulus involved in sensory perception of pain	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within detection of temperature stimulus involved in thermoception	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within diet induced thermogenesis	ISO Inferred from Sequence Orthology more info
involved_in excitatory postsynaptic potential	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within fever generation	ISO Inferred from Sequence Orthology more info
involved_in glutamate secretion	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within lipid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in microglial cell activation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in monoatomic ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of establishment of blood-brain barrier	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of heart rate	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of mitochondrial membrane potential	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of systemic arterial blood pressure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within peptide secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cytosolic calcium ion concentration	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of nitric oxide biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein homotetramerization	IDA Inferred from Direct Assay more info	PubMed
involved_in response to capsazepine	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to capsazepine	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to heat	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to heat	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to pH	IDA Inferred from Direct Assay more info	PubMed
involved_in response to pH	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to pH	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to pain	ISO Inferred from Sequence Orthology more info
involved_in response to peptide hormone	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within sensory perception of mechanical stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within sensory perception of pain	ISO Inferred from Sequence Orthology more info
involved_in sensory perception of taste	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within sensory perception of taste	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within smooth muscle contraction involved in micturition	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within temperature homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within thermoception	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within urinary bladder smooth muscle contraction	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in GABA-ergic synapse	ISO Inferred from Sequence Orthology more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in dendritic spine membrane	IEA Inferred from Electronic Annotation more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in neuron projection	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: transient receptor potential cation channel subfamily V member 1

Names: OTRPC1; capsaicin receptor; deltaN-TRPV1; osm-9-like TRP channel 1; transient receptor potential vanilloid 1 supraoptic nucleus; vanilloid receptor 1; vanilloid receptor subtype 1; vanilloid receptor type 1 like protein 1; vanilloid type 1 receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031982.1 → NP_114188.1 transient receptor potential cation channel subfamily V member 1

See identical proteins and their annotated locations for NP_114188.1

Status: PROVISIONAL

Source sequence(s)

AF029310

UniProtKB/Swiss-Prot

O35433, Q920B3, Q920B4, Q9JLM0, Q9JM56, Q9JM57

UniProtKB/TrEMBL

A6HGJ0, A6HGJ1

Related

ENSRNOP00000026493.3, ENSRNOT00000026493.8

Conserved Domains (2) summary

sd00045
Location:201 → 231

ANK; ANK repeat [structural motif]

cd22196
Location:109 → 760

TRPV1; Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 1