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    Tent4b terminal nucleotidyltransferase 4B [ Mus musculus (house mouse) ]

    Gene ID: 214627, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Tent4bprovided by MGI
    Official Full Name
    terminal nucleotidyltransferase 4Bprovided by MGI
    Primary source
    MGI:MGI:1917820
    See related
    Ensembl:ENSMUSG00000036779 AllianceGenome:MGI:1917820
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Papd5; 5830428A09; 5730445M16Rik
    Summary
    Predicted to enable guanylyltransferase activity; poly(A) RNA polymerase activity; and telomerase RNA binding activity. Predicted to be involved in several processes, including RNA metabolic process; negative regulation of telomere maintenance via telomerase; and regulation of mRNA stability. Predicted to be located in cytosol and plasma membrane. Predicted to be part of TRAMP complex. Predicted to be active in nucleolus. Orthologous to human TENT4B (terminal nucleotidyltransferase 4B). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 23.2), whole brain E14.5 (RPKM 8.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tent4b in Genome Data Viewer
    Location:
    8 C3; 8 43.06 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (88925229..88989942)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (88199213..88263314)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1765 Neighboring gene CTD nuclear envelope phosphatase 1 regulatory subunit 1 Neighboring gene microRNA 7071 Neighboring gene HEAT repeat containing 3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:90808880-90809067 Neighboring gene adenylate cyclase 7 Neighboring gene bromodomain containing 7 Neighboring gene STARR-positive B cell enhancer ABC_E6670 Neighboring gene predicted gene, 34751

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function. Zhang T, et al. Sci Rep, 2017 Apr 5. PMID 28378742, Free PMC Article
    2. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
    3. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
    4. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
    5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-directed DNA polymerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanylyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables guanylyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables poly(A) RNA polymerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables poly(A) RNA polymerase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables poly(A) RNA polymerase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables telomerase RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in RNA 3' uridylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in RNA 3' uridylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in RNA 3'-end processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in carbohydrate homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in carbohydrate homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in histone mRNA catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in histone mRNA catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in mRNA 3'-end processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mRNA 3'-end processing ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in miRNA catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in miRNA catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of nuclear-transcribed mRNA poly(A) tail shortening ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of nuclear-transcribed mRNA poly(A) tail shortening ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of telomere maintenance via telomerase ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in poly(A)-dependent snoRNA 3'-end processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in poly(A)-dependent snoRNA 3'-end processing ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in polyadenylation-dependent ncRNA catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in polyadenylation-dependent ncRNA catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of 3'-UTR-mediated mRNA stabilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of 3'-UTR-mediated mRNA stabilization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of TRAMP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of TRAMP complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    terminal nucleotidyltransferase 4B
    Names
    PAP associated domain containing 5
    PAP-associated domain-containing protein 5
    TRF4-2
    TUTase 3
    non-canonical poly(A) RNA polymerase PAPD5
    terminal guanylyltransferase
    terminal nucleotidyltransferase 4A
    terminal uridylyltransferase 3
    topoisomerase-related function protein 4-2
    NP_001157969.1
    NP_001157970.1
    NP_001157971.1
    NP_001359262.1
    NP_001401932.1
    NP_001401933.1
    XP_006530893.1
    XP_006530896.1
    XP_017168142.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164497.2 → NP_001157969.1  terminal nucleotidyltransferase 4B isoform a

      See identical proteins and their annotated locations for NP_001157969.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Both variants 1 and 2 encode the same isoform.
      Source sequence(s)
      AC126034, AC155170
      Consensus CDS
      CCDS52629.1
      UniProtKB/TrEMBL
      E9QJT6, F6UPY1
      Related
      ENSMUSP00000112766.2, ENSMUST00000119033.8
      Conserved Domains (1) summary
      COG5260
      Location:181 → 453
      TRF4; DNA polymerase sigma [Replication, recombination and repair]

    2. NM_001164498.2 → NP_001157970.1  terminal nucleotidyltransferase 4B isoform a

      See identical proteins and their annotated locations for NP_001157970.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1, and encodes the longer isoform (a). Both variants 1 and 2 encode the same isoform.
      Source sequence(s)
      AC126034, AC155170
      Consensus CDS
      CCDS52629.1
      UniProtKB/TrEMBL
      E9QJT6, F6UPY1
      Related
      ENSMUSP00000112608.2, ENSMUST00000118952.8
      Conserved Domains (1) summary
      COG5260
      Location:181 → 453
      TRF4; DNA polymerase sigma [Replication, recombination and repair]

    3. NM_001164499.2 → NP_001157971.1  terminal nucleotidyltransferase 4B isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon in the central coding region, compared to variant 1. The resulting isoform (b) lacks an internal segment, compared to isoform a.
      Source sequence(s)
      AC126034, AC155170
      Consensus CDS
      CCDS52630.1
      UniProtKB/TrEMBL
      B7ZMU2, F8WI26
      Related
      ENSMUSP00000067971.4, ENSMUST00000066748.11
      Conserved Domains (1) summary
      COG5260
      Location:181 → 410
      TRF4; DNA polymerase sigma [Replication, recombination and repair]

    4. NM_001372333.2 → NP_001359262.1  terminal nucleotidyltransferase 4B isoform c

      Status: VALIDATED

      Source sequence(s)
      AC126034, AC155170
      UniProtKB/TrEMBL
      F6UPY1
      Related
      ENSMUSP00000160021.1, ENSMUST00000249924.1
      Conserved Domains (1) summary
      COG5260
      Location:201 → 473
      TRF4; DNA polymerase sigma [Replication, recombination and repair]

    5. NM_001415003.1 → NP_001401932.1  terminal nucleotidyltransferase 4B isoform d

      Status: VALIDATED

      Source sequence(s)
      AC126034, AC155170
      Related
      ENSMUSP00000120503.3, ENSMUST00000154115.3

    6. NM_001415004.1 → NP_001401933.1  terminal nucleotidyltransferase 4B isoform e

      Status: VALIDATED

      Source sequence(s)
      AC126034, AC155170
      UniProtKB/Swiss-Prot
      A6H635, Q68ED3, Q8C0K6

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      88925229..88989942
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006530830.5 → XP_006530893.1  terminal nucleotidyltransferase 4B isoform X1

      UniProtKB/TrEMBL
      F6UPY1
      Conserved Domains (1) summary
      COG5260
      Location:201 → 473
      TRF4; DNA polymerase sigma [Replication, recombination and repair]

    2. XM_006530833.5 → XP_006530896.1  terminal nucleotidyltransferase 4B isoform X4

      UniProtKB/TrEMBL
      F6UPY1
      Conserved Domains (1) summary
      COG5260
      Location:201 → 473
      TRF4; DNA polymerase sigma [Replication, recombination and repair]

    3. XM_017312653.2 → XP_017168142.1  terminal nucleotidyltransferase 4B isoform X2

      UniProtKB/TrEMBL
      B7ZMU2
      Conserved Domains (1) summary
      COG5260
      Location:201 → 430
      TRF4; DNA polymerase sigma [Replication, recombination and repair]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q68ED3.2 GenPept UniProtKB/Swiss-Prot:Q68ED3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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