Vldlr very low density lipoprotein receptor [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Vldlrprovided by MGI
Official Full Name: very low density lipoprotein receptorprovided by MGI
Primary source: MGI:MGI:98935
See related: Ensembl:ENSMUSG00000024924 AllianceGenome:MGI:98935
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Enables reelin receptor activity. Involved in several processes, including nervous system development; positive regulation of dendrite development; and reelin-mediated signaling pathway. Acts upstream of or within positive regulation of protein kinase activity. Located in extracellular space. Is active in glutamatergic synapse. Is expressed in several structures, including alimentary system; brain; genitourinary system; sensory organ; and skeleton. Used to study age related macular degeneration 1. Human ortholog(s) of this gene implicated in Alzheimer's disease; cerebellar ataxia, impaired intellectual development, and dysequilibrium syndrome 1; and dementia. Orthologous to human VLDLR (very low density lipoprotein receptor). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in heart adult (RPKM 21.6), subcutaneous fat pad adult (RPKM 8.9) and 17 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 C1; 19 21.77 cM

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (27190070..27231631)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (27216480..27254231)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Very low-density lipoprotein receptor mediates triglyceride-rich lipoprotein-induced oxidative stress and insulin resistance.
Title: Very low-density lipoprotein receptor mediates triglyceride-rich lipoprotein-induced oxidative stress and insulin resistance.
SIRT1 regulates hepatic vldlr levels.
Title: SIRT1 regulates hepatic vldlr levels.
Thrombospondin 1 and Reelin act through Vldlr to regulate cardiac growth and repair.
Title: Thrombospondin 1 and Reelin act through Vldlr to regulate cardiac growth and repair.
VLDL-VLDLR axis facilitates brown fat thermogenesis through replenishment of lipid fuels and PPARbeta/delta activation.
Title: VLDL-VLDLR axis facilitates brown fat thermogenesis through replenishment of lipid fuels and PPARβ/δ activation.
VLDLR and ApoER2 are receptors for multiple alphaviruses.
Title: VLDLR and ApoER2 are receptors for multiple alphaviruses.
Soluble very low-density lipoprotein receptor (sVLDLR) inhibits fibrosis in neovascular age-related macular degeneration.
Title: Soluble very low-density lipoprotein receptor (sVLDLR) inhibits fibrosis in neovascular age-related macular degeneration.
Very low-density lipoprotein receptor increases in a liver-specific manner due to protein deficiency but does not affect fatty liver in mice.
Title: Very low-density lipoprotein receptor increases in a liver-specific manner due to protein deficiency but does not affect fatty liver in mice.
ADAM17 mediates ectodomain shedding of the soluble VLDL receptor fragment in the retinal epithelium.
Title: ADAM17 mediates ectodomain shedding of the soluble VLDL receptor fragment in the retinal epithelium.
VLDLR is not essential for reelin-induced neuronal aggregation but suppresses neuronal invasion into the marginal zone.
Title: VLDLR is not essential for reelin-induced neuronal aggregation but suppresses neuronal invasion into the marginal zone.
The miR-106b-25 cluster regulates atherosclerosis in mice by influencing clearance of VLDL and LDL from the plasma.
Title: Deletion of the Mir-106b~ 25 MicroRNA cluster attenuates atherosclerosis in Apolipoprotein E knockout mice.

Submit: New GeneRIF Correction See all GeneRIFs (56)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (2) 1 citation
Endonuclease-mediated (4)
Spontaneous (1)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI451093 (e-PCR)
- UniSTS:186147

RH124796 (e-PCR)
- UniSTS:161618

09.MMHAP31FLC3.seq (e-PCR)
- UniSTS:122971

Vldlr (e-PCR), detects polymorphism
- UniSTS:144760

Vldlr (e-PCR), detects polymorphism
- UniSTS:530809

Vldlr (e-PCR), detects polymorphism
- UniSTS:530810

U06670 (e-PCR)
- UniSTS:125653

AW047288 (e-PCR)
- UniSTS:166140

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables apolipoprotein binding	IBA Inferred from Biological aspect of Ancestor more info
enables apolipoprotein binding	IEA Inferred from Electronic Annotation more info
enables apolipoprotein binding	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables calcium-dependent protein binding	IEA Inferred from Electronic Annotation more info
enables calcium-dependent protein binding	ISO Inferred from Sequence Orthology more info
enables cargo receptor activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables reelin receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables reelin receptor activity	IGI Inferred from Genetic Interaction more info	PubMed
enables reelin receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables very-low-density lipoprotein particle binding	IEA Inferred from Electronic Annotation more info
enables very-low-density lipoprotein particle binding	ISO Inferred from Sequence Orthology more info
enables very-low-density lipoprotein particle receptor activity	ISO Inferred from Sequence Orthology more info
enables very-low-density lipoprotein particle receptor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in cellular response to hypoxia	ISO Inferred from Sequence Orthology more info
involved_in cholesterol metabolic process	IEA Inferred from Electronic Annotation more info
involved_in dendrite morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glycoprotein transport	IEA Inferred from Electronic Annotation more info
involved_in glycoprotein transport	ISO Inferred from Sequence Orthology more info
involved_in lipid transport	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of dendrite development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of protein kinase activity	IGI Inferred from Genetic Interaction more info	PubMed
involved_in receptor-mediated endocytosis	IEA Inferred from Electronic Annotation more info
involved_in receptor-mediated endocytosis	ISO Inferred from Sequence Orthology more info
involved_in reelin-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in reelin-mediated signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of synapse assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of synapse assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ventral spinal cord development	IEP Inferred from Expression Pattern more info	PubMed
involved_in very-low-density lipoprotein particle clearance	ISO Inferred from Sequence Orthology more info
involved_in very-low-density lipoprotein particle clearance	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in apical part of cell	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in clathrin-coated pit	IEA Inferred from Electronic Annotation more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	ISO Inferred from Sequence Orthology more info	PubMed
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info	PubMed
is_active_in synapse	IDA Inferred from Direct Assay more info	PubMed
part_of very-low-density lipoprotein particle	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: very low-density lipoprotein receptor

Names: VLDL receptor; VLDL-R

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001161420.1 → NP_001154892.1 very low-density lipoprotein receptor isoform b precursor

See identical proteins and their annotated locations for NP_001154892.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an in-frame exon in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform b), compared to isoform a.

Source sequence(s)

AC119982, AK036010, AK076172, AK136838, BU504025, U06670

Consensus CDS

CCDS50411.1

UniProtKB/TrEMBL

Q3UVX6, Q91YY0

Related

ENSMUSP00000126730.2, ENSMUST00000172302.8

Conserved Domains (7) summary

smart00192
Location:71 → 103

LDLa; Low-density lipoprotein receptor domain class A

smart00135
Location:508 → 547

LY; Low-density lipoprotein-receptor YWTD domain

smart00179
Location:396 → 426

EGF_CA; Calcium-binding EGF-like domain

cd00112
Location:33 → 67

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

pfam00057
Location:237 → 273

Ldl_recept_a; Low-density lipoprotein receptor domain class A

pfam00058
Location:568 → 608

Ldl_recept_b; Low-density lipoprotein receptor repeat class B

pfam14670
Location:360 → 394

FXa_inhibition; Coagulation Factor Xa inhibitory site
NM_001347441.1 → NP_001334370.1 very low-density lipoprotein receptor isoform c precursor

Status: VALIDATED

Source sequence(s)

AC119982, AI451093

Consensus CDS

CCDS84429.1

UniProtKB/TrEMBL

F8WGI9, Q3UVX6

Conserved Domains (7) summary

smart00192
Location:71 → 103

LDLa; Low-density lipoprotein receptor domain class A

smart00135
Location:467 → 506

LY; Low-density lipoprotein-receptor YWTD domain

smart00179
Location:355 → 385

EGF_CA; Calcium-binding EGF-like domain

cd00112
Location:33 → 67

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

pfam00057
Location:196 → 232

Ldl_recept_a; Low-density lipoprotein receptor domain class A

pfam00058
Location:527 → 567

Ldl_recept_b; Low-density lipoprotein receptor repeat class B

pfam14670
Location:319 → 353

FXa_inhibition; Coagulation Factor Xa inhibitory site
NM_001412816.1 → NP_001399745.1 very low-density lipoprotein receptor isoform c precursor

Status: VALIDATED

Source sequence(s)

AC119982

UniProtKB/TrEMBL

F8WGI9

Related

ENSMUSP00000049145.7, ENSMUST00000047645.13
NM_013703.2 → NP_038731.2 very low-density lipoprotein receptor isoform a precursor

See identical proteins and their annotated locations for NP_038731.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer variant and encodes the longer isoform (a).

Source sequence(s)

AC119982, AK036010, AK076172, AK136838, BU504025, U06670

Consensus CDS

CCDS29721.1

UniProtKB/Swiss-Prot

P98156, Q64022

UniProtKB/TrEMBL

Q3UVX6

Related

ENSMUSP00000127329.2, ENSMUST00000167487.8

Conserved Domains (7) summary

smart00192
Location:71 → 103

LDLa; Low-density lipoprotein receptor domain class A

smart00135
Location:508 → 547

LY; Low-density lipoprotein-receptor YWTD domain

smart00179
Location:396 → 426

EGF_CA; Calcium-binding EGF-like domain

cd00112
Location:33 → 67

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

pfam00058
Location:568 → 608

Ldl_recept_b; Low-density lipoprotein receptor repeat class B

pfam00057
Location:237 → 273

Ldl_recept_a; Low-density lipoprotein receptor domain class A

pfam14670
Location:360 → 394

FXa_inhibition; Coagulation Factor Xa inhibitory site

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000085.7 Reference GRCm39 C57BL/6J

Range

27190070..27231631

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036161519.1 → XP_036017412.1 very low-density lipoprotein receptor isoform X6

Conserved Domains (5) summary

smart00135
Location:488 → 530

LY; Low-density lipoprotein-receptor YWTD domain

smart00179
Location:292 → 322

EGF_CA; Calcium-binding EGF-like domain

pfam00057
Location:133 → 169

Ldl_recept_a; Low-density lipoprotein receptor domain class A

pfam00058
Location:464 → 504

Ldl_recept_b; Low-density lipoprotein receptor repeat class B

pfam14670
Location:256 → 290

FXa_inhibition; Coagulation Factor Xa inhibitory site
XM_006526917.2 → XP_006526980.1 very low-density lipoprotein receptor isoform X1

See identical proteins and their annotated locations for XP_006526980.1

UniProtKB/Swiss-Prot

P98156, Q64022

UniProtKB/TrEMBL

Q3UVX6

Conserved Domains (7) summary

smart00192
Location:71 → 103

LDLa; Low-density lipoprotein receptor domain class A

smart00135
Location:508 → 547

LY; Low-density lipoprotein-receptor YWTD domain

smart00179
Location:396 → 426

EGF_CA; Calcium-binding EGF-like domain

cd00112
Location:33 → 67

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

pfam00058
Location:568 → 608

Ldl_recept_b; Low-density lipoprotein receptor repeat class B

pfam00057
Location:237 → 273

Ldl_recept_a; Low-density lipoprotein receptor domain class A

pfam14670
Location:360 → 394

FXa_inhibition; Coagulation Factor Xa inhibitory site
XM_030250866.2 → XP_030106726.1 very low-density lipoprotein receptor isoform X2

UniProtKB/TrEMBL

Q3UVX6, Q91YY0

Conserved Domains (7) summary

smart00192
Location:71 → 103

LDLa; Low-density lipoprotein receptor domain class A

smart00135
Location:508 → 547

LY; Low-density lipoprotein-receptor YWTD domain

smart00179
Location:396 → 426

EGF_CA; Calcium-binding EGF-like domain

cd00112
Location:33 → 67

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

pfam00057
Location:237 → 273

Ldl_recept_a; Low-density lipoprotein receptor domain class A

pfam00058
Location:568 → 608

Ldl_recept_b; Low-density lipoprotein receptor repeat class B

pfam14670
Location:360 → 394

FXa_inhibition; Coagulation Factor Xa inhibitory site
XM_030250868.2 → XP_030106728.1 very low-density lipoprotein receptor isoform X5

Conserved Domains (5) summary

smart00135
Location:488 → 530

LY; Low-density lipoprotein-receptor YWTD domain

smart00179
Location:292 → 322

EGF_CA; Calcium-binding EGF-like domain

pfam00058
Location:464 → 504

Ldl_recept_b; Low-density lipoprotein receptor repeat class B

pfam00057
Location:133 → 169

Ldl_recept_a; Low-density lipoprotein receptor domain class A

pfam14670
Location:256 → 290

FXa_inhibition; Coagulation Factor Xa inhibitory site
XM_006526919.4 → XP_006526982.1 very low-density lipoprotein receptor isoform X3

UniProtKB/TrEMBL

Q3UVX6

Conserved Domains (7) summary

smart00192
Location:71 → 103

LDLa; Low-density lipoprotein receptor domain class A

smart00135
Location:467 → 506

LY; Low-density lipoprotein-receptor YWTD domain

smart00179
Location:355 → 385

EGF_CA; Calcium-binding EGF-like domain

cd00112
Location:33 → 67

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

pfam00058
Location:527 → 567

Ldl_recept_b; Low-density lipoprotein receptor repeat class B

pfam00057
Location:196 → 232

Ldl_recept_a; Low-density lipoprotein receptor domain class A

pfam14670
Location:319 → 353

FXa_inhibition; Coagulation Factor Xa inhibitory site
XM_030250865.2 → XP_030106725.1 very low-density lipoprotein receptor isoform X1

UniProtKB/Swiss-Prot

P98156, Q64022

UniProtKB/TrEMBL

Q3UVX6

Conserved Domains (7) summary

smart00192
Location:71 → 103

LDLa; Low-density lipoprotein receptor domain class A

smart00135
Location:508 → 547

LY; Low-density lipoprotein-receptor YWTD domain

smart00179
Location:396 → 426

EGF_CA; Calcium-binding EGF-like domain

cd00112
Location:33 → 67

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

pfam00058
Location:568 → 608

Ldl_recept_b; Low-density lipoprotein receptor repeat class B

pfam00057
Location:237 → 273

Ldl_recept_a; Low-density lipoprotein receptor domain class A

pfam14670
Location:360 → 394

FXa_inhibition; Coagulation Factor Xa inhibitory site
XM_006526918.4 → XP_006526981.1 very low-density lipoprotein receptor isoform X1

See identical proteins and their annotated locations for XP_006526981.1

UniProtKB/Swiss-Prot

P98156, Q64022

UniProtKB/TrEMBL

Q3UVX6

Conserved Domains (7) summary

smart00192
Location:71 → 103

LDLa; Low-density lipoprotein receptor domain class A

smart00135
Location:508 → 547

LY; Low-density lipoprotein-receptor YWTD domain

smart00179
Location:396 → 426

EGF_CA; Calcium-binding EGF-like domain

cd00112
Location:33 → 67

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

pfam00058
Location:568 → 608

Ldl_recept_b; Low-density lipoprotein receptor repeat class B

pfam00057
Location:237 → 273

Ldl_recept_a; Low-density lipoprotein receptor domain class A

pfam14670
Location:360 → 394

FXa_inhibition; Coagulation Factor Xa inhibitory site
XM_036161516.1 → XP_036017409.1 very low-density lipoprotein receptor isoform X2

UniProtKB/TrEMBL

Q3UVX6, Q91YY0

Conserved Domains (7) summary

smart00192
Location:71 → 103

LDLa; Low-density lipoprotein receptor domain class A

smart00135
Location:508 → 547

LY; Low-density lipoprotein-receptor YWTD domain

smart00179
Location:396 → 426

EGF_CA; Calcium-binding EGF-like domain

cd00112
Location:33 → 67

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

pfam00057
Location:237 → 273

Ldl_recept_a; Low-density lipoprotein receptor domain class A

pfam00058
Location:568 → 608

Ldl_recept_b; Low-density lipoprotein receptor repeat class B

pfam14670
Location:360 → 394

FXa_inhibition; Coagulation Factor Xa inhibitory site
XM_036161518.1 → XP_036017411.1 very low-density lipoprotein receptor isoform X6

Conserved Domains (5) summary

smart00135
Location:488 → 530

LY; Low-density lipoprotein-receptor YWTD domain

smart00179
Location:292 → 322

EGF_CA; Calcium-binding EGF-like domain

pfam00057
Location:133 → 169

Ldl_recept_a; Low-density lipoprotein receptor domain class A

pfam00058
Location:464 → 504

Ldl_recept_b; Low-density lipoprotein receptor repeat class B

pfam14670
Location:256 → 290

FXa_inhibition; Coagulation Factor Xa inhibitory site