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    Creg1 cellular repressor of E1A-stimulated genes 1 [ Mus musculus (house mouse) ]

    Gene ID: 433375, updated on 9-Dec-2024

    Summary

    Official Symbol
    Creg1provided by MGI
    Official Full Name
    cellular repressor of E1A-stimulated genes 1provided by MGI
    Primary source
    MGI:MGI:1344382
    See related
    Ensembl:ENSMUSG00000040713 AllianceGenome:MGI:1344382
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Creg
    Summary
    Predicted to enable insulin-like growth factor receptor binding activity. Acts upstream of or within several processes, including autophagy; lysosomal lumen acidification; and regulation of DNA-templated transcription. Located in endosome and lysosome. Part of transcription regulator complex. Is expressed in central nervous system; liver; and ureter. Orthologous to human CREG1 (cellular repressor of E1A stimulated genes 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in placenta adult (RPKM 225.0), liver adult (RPKM 174.7) and 21 other tissues See more
    Orthologs
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    Genomic context

    See Creg1 in Genome Data Viewer
    Location:
    1 H2.3; 1 73.11 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (165591327..165602878)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (165763758..165775309)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_02911 Neighboring gene STARR-positive B cell enhancer mm9_chr1:167591001-167591302 Neighboring gene RCSD domain containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E1571 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:167636283-167636436 Neighboring gene STARR-positive B cell enhancer ABC_E11104 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:167648574-167648683 Neighboring gene predicted gene, 51752 Neighboring gene STARR-positive B cell enhancer ABC_E1572 Neighboring gene STARR-positive B cell enhancer ABC_E4374 Neighboring gene STARR-positive B cell enhancer ABC_E7771 Neighboring gene STARR-positive B cell enhancer ABC_E9064 Neighboring gene CD247 antigen Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:167732146-167732347 Neighboring gene predicted gene, 23402 Neighboring gene STARR-seq mESC enhancer starr_02912 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:167775596-167775783 Neighboring gene predicted gene, 32999

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    located_in endosome PubMed 
    is_active_in extracellular space  
    located_in extracellular space  
    located_in extracellular space  
    located_in lysosome PubMed 
    part_of transcription regulator complex PubMed 

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011804.3NP_035934.1  protein CREG1 precursor

      See identical proteins and their annotated locations for NP_035934.1

      Status: VALIDATED

      Source sequence(s)
      AC124587, AW495378
      Consensus CDS
      CCDS35759.1
      UniProtKB/Swiss-Prot
      O88668, Q3UNP8, Q8C3I1
      Related
      ENSMUSP00000107060.4, ENSMUST00000111432.10
      Conserved Domains (1) summary
      pfam13883
      Location:50216
      Pyrid_oxidase_2; Pyridoxamine 5'-phosphate oxidase

    RNA

    1. NR_149310.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC124587, AK150006, AW495378
      Related
      ENSMUST00000140769.2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      165591327..165602878
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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