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    Slc14a1 solute carrier family 14 (urea transporter), member 1 [ Mus musculus (house mouse) ]

    Gene ID: 108052, updated on 9-Dec-2024

    Summary

    Official Symbol
    Slc14a1provided by MGI
    Official Full Name
    solute carrier family 14 (urea transporter), member 1provided by MGI
    Primary source
    MGI:MGI:1351654
    See related
    Ensembl:ENSMUSG00000059336 AllianceGenome:MGI:1351654
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    UT-B; Utb1; 2610507K20Rik; 3021401A05Rik
    Summary
    Enables urea transmembrane transporter activity and water transmembrane transporter activity. Acts upstream of or within establishment of localization in cell; urea transport; and water transport. Located in basolateral plasma membrane. Is expressed in several structures, including central nervous system; genitourinary system; limb; musculature; and sensory organ. Orthologous to human SLC14A1 (solute carrier family 14 member 1 (Kidd blood group)). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in ovary adult (RPKM 19.4), bladder adult (RPKM 19.2) and 13 other tissues See more
    Orthologs
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    Genomic context

    See Slc14a1 in Genome Data Viewer
    Location:
    18 E3; 18 52.49 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (78143306..78185334, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (78100091..78142119, complement)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2514 Neighboring gene ectopic P-granules 5 autophagy tethering factor Neighboring gene sialic acid binding Ig-like lectin 15 Neighboring gene STARR-seq mESC enhancer starr_45139 Neighboring gene predicted gene, 36338 Neighboring gene solute carrier family 14 (urea transporter), member 2 Neighboring gene STARR-positive B cell enhancer mm9_chr18:78408899-78409200 Neighboring gene STARR-seq mESC enhancer starr_45142 Neighboring gene STARR-seq mESC enhancer starr_45143 Neighboring gene predicted gene, 54027 Neighboring gene VISTA enhancer mm173 Neighboring gene 60S ribosomal protein L17 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Related articles in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (1)  1 citation

    General gene information

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    located_in basolateral plasma membrane PubMed 
    located_in membrane PubMed 
    located_in plasma membrane PubMed 
    located_in plasma membrane  
    located_in plasma membrane  

    General protein information

    Preferred Names
    urea transporter 1
    Names
    solute carrier family 14 member 1
    urea transporter B
    urea transporter, erythrocyte

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001171010.1NP_001164481.1  urea transporter 1 isoform a

      See identical proteins and their annotated locations for NP_001164481.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).
      Source sequence(s)
      AC112792, BC062816, BC086673, BY231473
      Consensus CDS
      CCDS50330.1
      UniProtKB/Swiss-Prot
      Q8VHL0
      Related
      ENSMUSP00000125114.2, ENSMUST00000160292.8
      Conserved Domains (1) summary
      pfam03253
      Location:111394
      UT; Urea transporter
    2. NM_001171011.1NP_001164482.1  urea transporter 1 isoform b

      See identical proteins and their annotated locations for NP_001164482.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (b) is shorter than isoform 1. Variants 2 and 3 encode the same isoform (b).
      Source sequence(s)
      AK041979, BC062816, BC086673
      Consensus CDS
      CCDS29360.1
      UniProtKB/Swiss-Prot
      Q3U542, Q497G1, Q5RJG2, Q6PDP4, Q8VHL0, Q9CZX3
      Related
      ENSMUSP00000125367.2, ENSMUST00000160639.2
      Conserved Domains (1) summary
      pfam03253
      Location:55338
      UT; Urea transporter
    3. NM_028122.4NP_082398.1  urea transporter 1 isoform b

      See identical proteins and their annotated locations for NP_082398.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (b) is shorter than isoform 1. Variants 2 and 3 encode the same isoform (b).
      Source sequence(s)
      BC062816, BC086673, BY231473
      Consensus CDS
      CCDS29360.1
      UniProtKB/Swiss-Prot
      Q3U542, Q497G1, Q5RJG2, Q6PDP4, Q8VHL0, Q9CZX3
      Related
      ENSMUSP00000089421.6, ENSMUST00000091813.12
      Conserved Domains (1) summary
      pfam03253
      Location:55338
      UT; Urea transporter

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      78143306..78185334 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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