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    Rpl23 ribosomal protein L23 [ Mus musculus (house mouse) ]

    Gene ID: 65019, updated on 9-Dec-2024

    Summary

    Official Symbol
    Rpl23provided by MGI
    Official Full Name
    ribosomal protein L23provided by MGI
    Primary source
    MGI:MGI:1929455
    See related
    Ensembl:ENSMUSG00000071415 AllianceGenome:MGI:1929455
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2810009A01Rik
    Summary
    A structural constituent of ribosome. Predicted to be involved in several processes, including cellular response to actinomycin D; negative regulation of macromolecule metabolic process; and protein stabilization. Predicted to act upstream of with a positive effect on G1 to G0 transition and regulation of G1 to G0 transition. Predicted to act upstream of or within translation. Located in cytoplasm and nucleolus. Part of cytosolic large ribosomal subunit. Is active in synapse. Is expressed in several structures, including central nervous system; retina; and uterus. Orthologous to human RPL23 (ribosomal protein L23). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in liver E14 (RPKM 294.5), CNS E11.5 (RPKM 280.5) and 24 other tissues See more
    Orthologs
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    Genomic context

    See Rpl23 in Genome Data Viewer
    Location:
    11 D; 11 61.1 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (97668352..97673265, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (97777526..97782439, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene nuclear encoded tRNA cysteine 18 (anticodon GCA) Neighboring gene sperm microtubule associated protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E5272 Neighboring gene small nucleolar RNA, H/ACA box 21 Neighboring gene STARR-seq mESC enhancer starr_30635 Neighboring gene STARR-positive B cell enhancer ABC_E7052 Neighboring gene nuclear encoded tRNA cysteine 56 (anticodon GCA) Neighboring gene nuclear encoded tRNA cysteine 51 (anticodon GCA) Neighboring gene LIM and SH3 protein 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables large ribosomal subunit rRNA binding  
    enables protein binding PubMed 
    enables structural constituent of ribosome  
    enables structural constituent of ribosome PubMed 
    enables structural constituent of ribosome PubMed 
    enables transcription coactivator binding  
    enables transcription coactivator binding  
    enables ubiquitin ligase inhibitor activity  
    enables ubiquitin ligase inhibitor activity  
    enables ubiquitin protein ligase binding  
    enables ubiquitin protein ligase binding  
    Process Evidence Code Pubs
    involved_in G1 to G0 transition  
    acts_upstream_of_positive_effect G1 to G0 transition  
    involved_in cellular response to actinomycin D  
    involved_in cellular response to actinomycin D  
    involved_in cytoplasmic translation PubMed 
    involved_in negative regulation of transcription by RNA polymerase II  
    involved_in negative regulation of transcription by RNA polymerase II  
    involved_in negative regulation of ubiquitin protein ligase activity  
    involved_in negative regulation of ubiquitin-dependent protein catabolic process  
    involved_in negative regulation of ubiquitin-dependent protein catabolic process  
    involved_in positive regulation of cell population proliferation  
    involved_in positive regulation of cell population proliferation  
    involved_in positive regulation of gene expression  
    involved_in positive regulation of gene expression  
    involved_in positive regulation of signal transduction by p53 class mediator  
    involved_in positive regulation of signal transduction by p53 class mediator  
    involved_in protein stabilization  
    involved_in protein stabilization  
    involved_in protein-DNA complex disassembly  
    involved_in protein-DNA complex disassembly  
    involved_in regulation of G1 to G0 transition  
    acts_upstream_of_positive_effect regulation of G1 to G0 transition  
    acts_upstream_of_or_within translation PubMed 
    involved_in translation at postsynapse PubMed 
    involved_in translation at presynapse PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm PubMed 
    located_in cytoplasm  
    located_in cytosol  
    part_of cytosolic large ribosomal subunit  
    part_of cytosolic large ribosomal subunit PubMed 
    part_of cytosolic large ribosomal subunit PubMed 
    part_of cytosolic large ribosomal subunit  
    located_in cytosolic ribosome PubMed 
    located_in nucleolus PubMed 
    located_in nucleolus  
    located_in nucleoplasm  
    located_in nucleoplasm  
    is_active_in postsynapse PubMed 
    is_active_in postsynaptic density  
    is_active_in presynapse PubMed 
    part_of protein-containing complex  
    located_in ribosome  
    is_active_in ribosome PubMed 
    is_active_in synapse PubMed 
    is_active_in synapse PubMed 

    General protein information

    Preferred Names
    large ribosomal subunit protein uL14
    Names
    60S ribosomal protein L23

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022891.3NP_075029.1  large ribosomal subunit protein uL14

      See identical proteins and their annotated locations for NP_075029.1

      Status: VALIDATED

      Source sequence(s)
      AK012694, AK018730, CF612967, CN840510
      Consensus CDS
      CCDS25331.1
      UniProtKB/Swiss-Prot
      P62830, Q3THU4, Q9CZE6, Q9DCQ4
      Related
      ENSMUSP00000099435.5, ENSMUST00000103146.5
      Conserved Domains (1) summary
      PTZ00054
      Location:2139
      PTZ00054; 60S ribosomal protein L23; Provisional

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      97668352..97673265 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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