Dnm3os dynamin 3, opposite strand [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dnm3osprovided by MGI
Official Full Name: dynamin 3, opposite strandprovided by MGI
Primary source: MGI:MGI:3052332
See related: Ensembl:ENSMUSG00000078190 AllianceGenome:MGI:3052332
Gene type: ncRNA
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Hag2; Npn1; P/L01; 6030416H16Rik
Summary: Acts upstream of or within bone mineralization and skeletal system development. Is expressed in several structures, including alimentary system; embryo mesenchyme; genitourinary system; heart; and limb. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human all
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Genomic context

Location:: 1 H2.1; 1 70.06 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (162045192..162053119)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (162217623..162225550)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

DNM3OS Enhances the Apoptosis and Senescence of Spermatogonia Associated with Nonobstructive Azoospermia by Providing miR-214-5p and Decreasing E2F2 Expression.
Title: DNM3OS Enhances the Apoptosis and Senescence of Spermatogonia Associated with Nonobstructive Azoospermia by Providing miR-214-5p and Decreasing E2F2 Expression.
DNM3OS is a fibroblast-specific critical downstream effector of TGF-beta-induced lung myofibroblast activation. DNM3OS regulates this process in trans by giving rise to three distinct profibrotic mature miRNAs, which influence SMAD and non-SMAD components of TGF-beta signaling in a multifaceted way. In vivo, interfering with DNM3OS function not only prevents lung fibrosis but also improves established pulmonary fibrosis.
Title: The Long Noncoding RNA DNM3OS Is a Reservoir of FibromiRs with Major Functions in Lung Fibroblast Response to TGF-β and Pulmonary Fibrosis.
Upregulation of long noncoding RNA Dnm3os, disruption of its interaction with nucleolin, and epigenetic modifications at target genes promote macrophage inflammatory phenotype in diabetes mellitus.
Title: Diabetes Mellitus-Induced Long Noncoding RNA Dnm3os Regulates Macrophage Functions and Inflammation via Nuclear Mechanisms.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation

General gene information

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Markers

Dnm3os (e-PCR), detects polymorphism
- UniSTS:472838

Z31360 (e-PCR)
- UniSTS:158873

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within bone mineralization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within skeletal system development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.