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    Timp4 tissue inhibitor of metalloproteinase 4 [ Mus musculus (house mouse) ]

    Gene ID: 110595, updated on 9-Dec-2024

    Summary

    Official Symbol
    Timp4provided by MGI
    Official Full Name
    tissue inhibitor of metalloproteinase 4provided by MGI
    Primary source
    MGI:MGI:109125
    See related
    Ensembl:ENSMUSG00000030317 AllianceGenome:MGI:109125
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Timp-4
    Summary
    Predicted to enable metalloendopeptidase inhibitor activity and zinc ion binding activity. Acts upstream of or within Notch signaling pathway. Predicted to be located in sarcomere. Predicted to be active in extracellular matrix and extracellular space. Is expressed in several structures, including brain ventricular layer; genitourinary system; hemolymphoid system gland; musculature; and ventral grey horn. Human ortholog(s) of this gene implicated in nephroblastoma. Orthologous to human TIMP4 (TIMP metallopeptidase inhibitor 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in genital fat pad adult (RPKM 71.5), subcutaneous fat pad adult (RPKM 64.7) and 8 other tissues See more
    Orthologs
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    Genomic context

    See Timp4 in Genome Data Viewer
    Location:
    6 E3; 6 53.29 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (115221405..115229166, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (115244444..115252205, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 17733 Neighboring gene synapsin II Neighboring gene transcriptional adaptor 1 pseudogene Neighboring gene predicted gene, 38877 Neighboring gene predicted gene, 38878

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (2)  1 citation

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metalloendopeptidase inhibitor activity  
    enables metalloendopeptidase inhibitor activity  
    enables zinc ion binding  
    Component Evidence Code Pubs
    is_active_in extracellular matrix  
    located_in extracellular region  
    is_active_in extracellular space  
    located_in extracellular space  
    located_in sarcomere  

    General protein information

    Preferred Names
    metalloproteinase inhibitor 4
    Names
    tissue inhibitor of metalloproteinases 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356406.1NP_001343335.1  metalloproteinase inhibitor 4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC153907
      UniProtKB/TrEMBL
      A0A0N4SUR1
      Conserved Domains (1) summary
      cl02512
      Location:30176
      NTR_like; NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the ...
    2. NM_080639.4NP_542370.3  metalloproteinase inhibitor 4 isoform 1 precursor

      See identical proteins and their annotated locations for NP_542370.3

      Status: VALIDATED

      Source sequence(s)
      AC153907
      Consensus CDS
      CCDS20438.1
      UniProtKB/Swiss-Prot
      Q924B7, Q9JHB3
      UniProtKB/TrEMBL
      Q3USH7, Q8C577, Q8CAG3
      Related
      ENSMUSP00000032462.7, ENSMUST00000032462.9
      Conserved Domains (1) summary
      cd03585
      Location:30211
      NTR_TIMP; NTR domain, TIMP subfamily; TIMPs, or tissue inibitors of metalloproteases, are essential regulators of extracellular matrix turnover and remodeling. They form complexes with matrix metalloproteases (MMPs) and inactivate them irreversibly by ...

    RNA

    1. NR_151459.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC153907

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      115221405..115229166 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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