Zfp658 zinc finger protein 658 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Zfp658provided by MGI
Official Full Name: zinc finger protein 658provided by MGI
Primary source: MGI:MGI:2652821
See related: Ensembl:ENSMUSG00000056592 AllianceGenome:MGI:2652821
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II and positive regulation of transcription by RNA polymerase II. Predicted to be located in cytosol and nucleolus. Predicted to be active in nucleus. Orthologous to human ZNF175 (zinc finger protein 175). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in CNS E18 (RPKM 3.4), CNS E14 (RPKM 3.0) and 22 other tissues See more
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Genomic context

Location:: 7 B3; 7 28.25 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (43211794..43225566)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (43562202..43576142)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)

General gene information

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Markers

D7Dcr13 (e-PCR), detects polymorphism
- UniSTS:507769

D7Mit314 (e-PCR), detects polymorphism
- UniSTS:131215

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: zinc finger protein 658

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001008549.2 → NP_001008549.1 zinc finger protein 658

See identical proteins and their annotated locations for NP_001008549.1

Status: VALIDATED

Source sequence(s)

AC154108

Consensus CDS

CCDS39931.1

UniProtKB/TrEMBL

Q5PPQ4

Related

ENSMUSP00000103606.2, ENSMUST00000107972.8

Conserved Domains (3) summary

smart00349
Location:23 → 80

KRAB; krueppel associated box

COG5048
Location:493 → 887

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:638 → 658

ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

43211794..43225566

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006540757.4 → XP_006540820.1 zinc finger protein 658 isoform X1

See identical proteins and their annotated locations for XP_006540820.1

UniProtKB/TrEMBL

Q5PPQ4

Conserved Domains (3) summary

smart00349
Location:23 → 80

KRAB; krueppel associated box

COG5048
Location:493 → 887

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:638 → 658

ZF_C2H2; C2H2 Zn finger [structural motif]