Nip7 NIP7, nucleolar pre-rRNA processing protein [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nip7provided by MGI
Official Full Name: NIP7, nucleolar pre-rRNA processing proteinprovided by MGI
Primary source: MGI:MGI:1913414
See related: Ensembl:ENSMUSG00000031917 AllianceGenome:MGI:1913414
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: PEachy; 1110017C15Rik; 6330509M23Rik
Summary: Predicted to enable RNA binding activity. Predicted to be involved in ribosomal large subunit biogenesis. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of preribosome, large subunit precursor. Predicted to be active in nucleolus. Is expressed in several structures, including central nervous system; gut; nasal cavity epithelium; submandibular gland primordium; and tooth. Orthologous to human NIP7 (nucleolar pre-rRNA processing protein NIP7). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 14.3), placenta adult (RPKM 13.2) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 D3; 8 53.57 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (107783509..107787563)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (107056877..107060931)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D11Bhm20 (e-PCR), detects polymorphism
- UniSTS:141619

D9Mit34.1 (e-PCR), detects polymorphism
- UniSTS:131903

RH125918 (e-PCR)
- UniSTS:162636

RH124919 (e-PCR)
- UniSTS:161741

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in ribosomal large subunit biogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in ribosome assembly	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in nucleolus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
part_of preribosome, large subunit precursor	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: 60S ribosome subunit biogenesis protein NIP7 homolog

Names: kDa93; nuclear import 7 homolog; nucleolar pre-rRNA processing protein NIP7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001164472.1 → NP_001157944.1 60S ribosome subunit biogenesis protein NIP7 homolog isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.

Source sequence(s)

AC123868

Consensus CDS

CCDS52665.1

UniProtKB/TrEMBL

E9Q109

Related

ENSMUSP00000126153.2, ENSMUST00000170962.3

Conserved Domains (1) summary

cl00607
Location:1 → 129

PUA; PUA domain
NM_025391.2 → NP_079667.2 60S ribosome subunit biogenesis protein NIP7 homolog isoform 1

See identical proteins and their annotated locations for NP_079667.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

AC123868, AK003739, AK014290

Consensus CDS

CCDS22644.1

UniProtKB/Swiss-Prot

Q9CXK8, Q9D1B4

Related

ENSMUSP00000034392.6, ENSMUST00000034392.13

Conserved Domains (1) summary

COG1374
Location:1 → 176

NIP7; Rbosome biogenesis protein Nip4, contains PUA domain [Translation, ribosomal structure and biogenesis]

RNA

NR_028367.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (3) includes an additional segment, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AC123868, BE623972