Adrb2 adrenergic receptor, beta 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Adrb2provided by MGI
Official Full Name: adrenergic receptor, beta 2provided by MGI
Primary source: MGI:MGI:87938
See related: Ensembl:ENSMUSG00000045730 AllianceGenome:MGI:87938
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Badm; Gpcr7; Adrb-2
Summary: This intronless gene belongs to the G-protein-coupled receptor superfamily, which includes transmembrane proteins that play a role in signal transduction across biological membranes resulting in a variety of physiological responses. The encoded protein is a beta-2 adrenergic receptor which is activated by catecholamine ligands such as adrenaline and epinephrine. The protein participates in the classical signaling pathway involving G protein, adenylyl cyclase, cAMP (3'-5'-cyclic adenosine monophosphate) and protein kinase A (PKA). In humans, this gene is implicated in susceptibility to nocturnal asthma, obesity and type 2 diabetes. [provided by RefSeq, Apr 2013]
Orthologs: human all
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Genomic context

Location:: 18 E1; 18 35.1 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	18	NC_000084.7 (62310784..62313052, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	18	NC_000084.6 (62177713..62179981, complement)

Chromosome 18 - NC_000084.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ligand-independent function of beta2-adrenergic receptor affects IgE-mediated Ca[2+] influx in mast cells.
Title: Ligand-independent function of β2-adrenergic receptor affects IgE-mediated Ca(2+) influx in mast cells.
Gut microbe-generated phenylacetylglutamine is an endogenous allosteric modulator of beta2-adrenergic receptors.
Title: Gut microbe-generated phenylacetylglutamine is an endogenous allosteric modulator of β2-adrenergic receptors.
Internalized beta2-Adrenergic Receptors Oppose PLC-Dependent Hypertrophic Signaling.
Title: Internalized β2-Adrenergic Receptors Oppose PLC-Dependent Hypertrophic Signaling.
Beta2 adrenergic receptor-mediated abnormal myelopoiesis drives neuroinflammation in aged patients with traumatic brain injury.
Title: Beta2 adrenergic receptor-mediated abnormal myelopoiesis drives neuroinflammation in aged patients with traumatic brain injury.
Chronic psychological stress aggravates psoriasis-like skin inflammation via overactivation of beta2-adrenoceptor and nuclear factor kappa B pathways.
Title: Chronic psychological stress aggravates psoriasis-like skin inflammation via overactivation of β(2)-adrenoceptor and nuclear factor kappa B pathways.
Chronic stress promotes gastric cancer progression via the adrenoceptor beta 2/PlexinA1 pathway.
Title: Chronic stress promotes gastric cancer progression via the adrenoceptor beta 2/PlexinA1 pathway.
Chronic stress promotes colorectal cancer progression by enhancing glycolysis through beta2-AR/CREB1 signal pathway.
Title: Chronic stress promotes colorectal cancer progression by enhancing glycolysis through β2-AR/CREB1 signal pathway.
Activation of beta2-adrenergic Receptor Ameliorates Amyloid-beta-induced Mitophagy Defects and Tau Pathology in Mice.
Title: Activation of β2-adrenergic Receptor Ameliorates Amyloid-β-induced Mitophagy Defects and Tau Pathology in Mice.
Muscle Stem Cell Function Is Impaired in beta2-Adrenoceptor Knockout Mice.
Title: Muscle Stem Cell Function Is Impaired in β2-Adrenoceptor Knockout Mice.
beta2-Adrenoceptor Deficiency Results in Increased Calcified Cartilage Thickness and Subchondral Bone Remodeling in Murine Experimental Osteoarthritis.
Title: β2-Adrenoceptor Deficiency Results in Increased Calcified Cartilage Thickness and Subchondral Bone Remodeling in Murine Experimental Osteoarthritis.

Submit: New GeneRIF Correction See all GeneRIFs (181)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (7)
Targeted (4) 1 citation

General gene information

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Markers

UniSTS:471069 (e-PCR)
- UniSTS:471069

Adrb2 (e-PCR), detects polymorphism
- UniSTS:471069

X15643 (e-PCR)
- UniSTS:181131

ADRB2sts1 (e-PCR)
- UniSTS:258478

Adrb2 (e-PCR), detects polymorphism
- UniSTS:256462

Adrb2 (e-PCR), detects polymorphism
- UniSTS:532446

NoName (e-PCR)
- UniSTS:237819

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables B2 bradykinin receptor binding	ISO Inferred from Sequence Orthology more info
enables G-protein alpha-subunit binding	ISO Inferred from Sequence Orthology more info
enables adenylate cyclase binding	IDA Inferred from Direct Assay more info	PubMed
enables amyloid-beta binding	IEA Inferred from Electronic Annotation more info
enables amyloid-beta binding	ISO Inferred from Sequence Orthology more info
enables beta2-adrenergic receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables beta2-adrenergic receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables beta2-adrenergic receptor activity	ISO Inferred from Sequence Orthology more info
enables enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables ionotropic glutamate receptor binding	ISO Inferred from Sequence Orthology more info
enables norepinephrine binding	IBA Inferred from Biological aspect of Ancestor more info
enables norepinephrine binding	ISO Inferred from Sequence Orthology more info
enables norepinephrine binding	ISS Inferred from Sequence or Structural Similarity more info
enables potassium channel regulator activity	IEA Inferred from Electronic Annotation more info
enables potassium channel regulator activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein phosphatase 2A binding	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables receptor-receptor interaction	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in AMPA selective glutamate receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within adenylate cyclase-activating G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-activating adrenergic receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-activating adrenergic receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-activating adrenergic receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in adrenergic receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in associative learning	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within bone resorption	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within brown fat cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cellular response to amyloid-beta	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cellular response to amyloid-beta	ISO Inferred from Sequence Orthology more info
involved_in cellular response to hypoxia	ISO Inferred from Sequence Orthology more info
involved_in diaphragm contraction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within diet induced thermogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in excitatory postsynaptic potential	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within heat generation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of G protein-coupled receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of multicellular organism growth	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of ossification	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of smooth muscle contraction	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of urine volume	ISO Inferred from Sequence Orthology more info
involved_in norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of AMPA receptor activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MAPK cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of autophagosome maturation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of bone mineralization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cAMP/PKA signal transduction	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of calcium ion import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cold-induced thermogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of lipophagy	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of mini excitatory postsynaptic potential	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of potassium ion transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein kinase A signaling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of skeletal muscle tissue growth	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of sodium ion transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of the force of heart contraction by epinephrine	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in presynaptic modulation of chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in receptor-mediated endocytosis	ISO Inferred from Sequence Orthology more info
involved_in receptor-mediated endocytosis	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of calcium ion transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of sodium ion transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of systemic arterial blood pressure by norepinephrine-epinephrine	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to catecholamine	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to cold	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of smooth muscle contraction	IGI Inferred from Genetic Interaction more info	PubMed
involved_in synaptic transmission, glutamatergic	ISO Inferred from Sequence Orthology more info
acts_upstream_of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in vasodilation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
is_active_in Schaffer collateral - CA1 synapse	ISO Inferred from Sequence Orthology more info
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in axon	ISO Inferred from Sequence Orthology more info
located_in caveola	ISO Inferred from Sequence Orthology more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in dendritic spine	ISO Inferred from Sequence Orthology more info
located_in early endosome	IEA Inferred from Electronic Annotation more info
located_in endosome	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body membrane	ISO Inferred from Sequence Orthology more info
is_active_in neuronal dense core vesicle	EXP Inferred from Experiment more info	PubMed
is_active_in neuronal dense core vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info
is_active_in postsynaptic membrane	ISO Inferred from Sequence Orthology more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info	PubMed
part_of receptor complex	ISS Inferred from Sequence or Structural Similarity more info
located_in sarcolemma	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: beta-2 adrenergic receptor

Names: beta 2-AR; beta-2 adrenoceptor; beta-2 adrenoreceptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.