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    Chrnb3 cholinergic receptor, nicotinic, beta polypeptide 3 [ Mus musculus (house mouse) ]

    Gene ID: 108043, updated on 27-Nov-2024

    Summary

    Official Symbol
    Chrnb3provided by MGI
    Official Full Name
    cholinergic receptor, nicotinic, beta polypeptide 3provided by MGI
    Primary source
    MGI:MGI:106212
    See related
    Ensembl:ENSMUSG00000031492 AllianceGenome:MGI:106212
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Acrb3; 5730417K16Rik
    Summary
    Predicted to enable acetylcholine binding activity and acetylcholine-gated monoatomic cation-selective channel activity. Predicted to contribute to acetylcholine receptor activity and heterocyclic compound binding activity. Involved in presynaptic modulation of chemical synaptic transmission. Is active in dopaminergic synapse. Is expressed in intestine; liver; nervous system; and retina. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; bipolar disorder; cocaine dependence; depressive disorder; and nicotine dependence. Orthologous to human CHRNB3 (cholinergic receptor nicotinic beta 3 subunit). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    NEW
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    Genomic context

    See Chrnb3 in Genome Data Viewer
    Location:
    8 A2; 8 16.0 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (27858688..27889758)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (27368711..27399730)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene testis expressed gene 24 Neighboring gene predicted gene, 53409 Neighboring gene cholinergic receptor, nicotinic, alpha polypeptide 6 Neighboring gene predicted gene, 24410

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2)  1 citation

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables acetylcholine binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables acetylcholine binding ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to acetylcholine receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables acetylcholine-gated monoatomic cation-selective channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables acetylcholine-gated monoatomic cation-selective channel activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables heterocyclic compound binding IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to heterocyclic compound binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transmembrane signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in acetylcholine receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in excitatory postsynaptic potential IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in membrane depolarization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in monoatomic ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in neuromuscular synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in presynaptic modulation of chemical synaptic transmission EXP
    Inferred from Experiment
    more info
    PubMed 
    involved_in presynaptic modulation of chemical synaptic transmission IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in presynaptic modulation of chemical synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to nicotine IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in synaptic transmission, cholinergic IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    part_of acetylcholine-gated channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of acetylcholine-gated channel complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of acetylcholine-gated channel complex ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in dopaminergic synapse EXP
    Inferred from Experiment
    more info
    PubMed 
    is_active_in dopaminergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in dopaminergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in presynapse IEA
    Inferred from Electronic Annotation
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    neuronal acetylcholine receptor subunit beta-3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_027454.4NP_081730.1  neuronal acetylcholine receptor subunit beta-3 isoform 2 precursor

      See identical proteins and their annotated locations for NP_081730.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate segment, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1.
      Source sequence(s)
      AK017571, AK030464, BC058193
      Consensus CDS
      CCDS22216.1
      UniProtKB/TrEMBL
      Q3UZS0
      Related
      ENSMUSP00000078428.5, ENSMUST00000079463.12
      Conserved Domains (3) summary
      TIGR00860
      Location:6440
      LIC; Cation transporter family protein
      pfam02931
      Location:35224
      Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
      pfam02932
      Location:231437
      Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region
    2. NM_173212.4NP_775304.1  neuronal acetylcholine receptor subunit beta-3 isoform 1 precursor

      See identical proteins and their annotated locations for NP_775304.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant represents the longer transcript and it encodes the longer protein (isoform 1).
      Source sequence(s)
      AK030464, AK133689, BC058193
      Consensus CDS
      CCDS22217.1
      UniProtKB/Swiss-Prot
      Q8BMN3, Q8R5H3, Q9CYK8
      UniProtKB/TrEMBL
      Q3UZS0
      Related
      ENSMUSP00000052297.4, ENSMUST00000060943.5
      Conserved Domains (3) summary
      TIGR00860
      Location:6455
      LIC; Cation transporter family protein
      pfam02931
      Location:35239
      Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
      pfam02932
      Location:246452
      Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      27858688..27889758
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030243231.2XP_030099091.1  neuronal acetylcholine receptor subunit beta-3 isoform X1

      Conserved Domains (1) summary
      TIGR00860
      Location:1320
      LIC; Cation transporter family protein