Prl2c3 prolactin family 2, subfamily c, member 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Prl2c3provided by MGI
Official Full Name: prolactin family 2, subfamily c, member 3provided by MGI
Primary source: MGI:MGI:1341833
See related: Ensembl:ENSMUSG00000056457 AllianceGenome:MGI:1341833
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ghd1; Plf2; MRP-2; MRP-3; PLF-2; PLF-3; Prl2c4; Mrpplf3; mrp/plf3
Summary: Enables growth factor activity and hormone activity. Acts upstream of or within positive regulation of hematopoietic stem cell proliferation. Located in extracellular space. Is expressed in ectoplacental cone; extraembryonic component; and placenta. [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward placenta adult (RPKM 2865.0) See more
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 13; 13 A1

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (12805705..12814982, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (12790816..12800093, complement)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data demonstrate that proliferin (Plf)1, Plf1 minus exon3, Plf2 and Mrp3 but not Mrp4 are expressed in mouse whole brain by diagnostic RT-PCR and Western blotting.
Title: Proliferin enhances microvilli formation and cell growth of neuroblastoma cells.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

Prl2c2 (e-PCR), detects polymorphism
- UniSTS:531485

Mrpplf3 (e-PCR), detects polymorphism
- UniSTS:143906

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables growth factor activity	IDA Inferred from Direct Assay more info	PubMed
enables hormone activity	IBA Inferred from Biological aspect of Ancestor more info
enables hormone activity	IDA Inferred from Direct Assay more info	PubMed
enables prolactin receptor binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cell surface receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in female pregnancy	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of hematopoietic stem cell proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in mammary gland development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of hematopoietic stem cell proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of lactation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of receptor signaling pathway via JAK-STAT	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to nutrient levels	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: prolactin-2C3

Names: growth hormone d1; mitogen-regulated protein 2; mitogen-regulated protein 3; prolactin-2C4; proliferin-2; proliferin-3

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_011118.2 → NP_035248.2 prolactin-2C3 precursor

See identical proteins and their annotated locations for NP_035248.2

Status: VALIDATED

Source sequence(s)

AK164068, BU755317

Consensus CDS

CCDS36595.1

UniProtKB/Swiss-Prot

P04768, P18918, Q498A5, Q6PDB6

UniProtKB/TrEMBL

A0A0M5HDY5, Q6P215, Q7TND2

Related

ENSMUSP00000097393.2, ENSMUST00000099805.3

Conserved Domains (1) summary

pfam00103
Location:33 → 224

Hormone_1; Somatotropin hormone family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000079.7 Reference GRCm39 C57BL/6J

Range

12805705..12814982 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006516579.1 → XP_006516642.1 prolactin-2C3 isoform X2

UniProtKB/TrEMBL

Q7TND2

Conserved Domains (1) summary

cl07831
Location:24 → 188

growth_hormone_like; Somatotropin/prolactin hormone family
XM_006516578.4 → XP_006516641.1 prolactin-2C3 isoform X1

UniProtKB/TrEMBL

Q6P215, Q7TND2

Conserved Domains (1) summary

pfam00103
Location:22 → 222

Hormone_1; Somatotropin hormone family