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    Rpa2 replication protein A2 [ Mus musculus (house mouse) ]

    Gene ID: 19891, updated on 3-Dec-2024

    Summary

    Official Symbol
    Rpa2provided by MGI
    Official Full Name
    replication protein A2provided by MGI
    Primary source
    MGI:MGI:1339939
    See related
    Ensembl:ENSMUSG00000028884 AllianceGenome:MGI:1339939
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    RPA34; Rf-A2
    Summary
    Enables DNA binding activity. Predicted to be involved in several processes, including DNA metabolic process; regulation of cell cycle phase transition; and regulation of double-strand break repair via homologous recombination. Predicted to be located in PML body and chromatin. Predicted to be part of DNA replication factor A complex. Predicted to be active in chromosome, telomeric region and site of double-strand break. Is expressed in blastocyst; brain; compacted morula; heart; and spermatocyte. Orthologous to human RPA2 (replication protein A2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in liver E14 (RPKM 35.0), liver E14.5 (RPKM 32.2) and 27 other tissues See more
    Orthologs
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    Genomic context

    See Rpa2 in Genome Data Viewer
    Location:
    4 D2.3; 4 65.88 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (132495671..132506057)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (132768360..132778746)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E9241 Neighboring gene X-linked Kx blood group related 8 Neighboring gene sphingomyelin phosphodiesterase, acid-like 3B Neighboring gene STARR-positive B cell enhancer ABC_E426 Neighboring gene STARR-positive B cell enhancer ABC_E6229 Neighboring gene thymocyte selection associated family member 2 Neighboring gene STARR-positive B cell enhancer ABC_E2125 Neighboring gene STARR-positive B cell enhancer ABC_E4675 Neighboring gene STARR-positive B cell enhancer ABC_E3521 Neighboring gene protein phosphatase 1, regulatory subunit 8 Neighboring gene predicted gene, 22767

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables G-rich strand telomeric DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables G-rich strand telomeric DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables damaged DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables damaged DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein phosphatase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables single-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables single-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables single-stranded DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables telomeric DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ubiquitin protein ligase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in DNA replication IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in DNA replication ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in DNA replication ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in base-excision repair ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in base-excision repair ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in double-strand break repair via homologous recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in double-strand break repair via homologous recombination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in double-strand break repair via homologous recombination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in mismatch repair ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mismatch repair ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in mitotic G1 DNA damage checkpoint signaling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mitotic G1 DNA damage checkpoint signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in nucleotide-excision repair IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in nucleotide-excision repair ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in nucleotide-excision repair ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein localization to chromosome ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein localization to chromosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of DNA damage checkpoint ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of DNA damage checkpoint ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of double-strand break repair via homologous recombination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of double-strand break repair via homologous recombination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in telomere maintenance ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in telomere maintenance ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    part_of DNA replication factor A complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of DNA replication factor A complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of DNA replication factor A complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    colocalizes_with PML body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in PML body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in PML body ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in chromatin IEA
    Inferred from Electronic Annotation
    more info
     
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in chromosome, telomeric region IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    colocalizes_with chromosome, telomeric region ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with chromosome, telomeric region ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in site of double-strand break IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    colocalizes_with site of double-strand break ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with site of double-strand break ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    replication protein A 32 kDa subunit
    Names
    30-kDa protein
    RF-A protein 2
    RP-A p32
    RP-A p34
    replication factor A protein 2
    replication protein A 34 kDa subunit

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001429787.1NP_001416716.1  replication protein A 32 kDa subunit isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL627130
      UniProtKB/TrEMBL
      Q99KL9
    2. NM_011284.4NP_035414.3  replication protein A 32 kDa subunit isoform 1

      See identical proteins and their annotated locations for NP_035414.3

      Status: VALIDATED

      Source sequence(s)
      AL627130
      Consensus CDS
      CCDS18734.1
      UniProtKB/Swiss-Prot
      Q3TE40, Q62193
      UniProtKB/TrEMBL
      Q99KL9
      Related
      ENSMUSP00000099621.5, ENSMUST00000102561.11
      Conserved Domains (3) summary
      COG5235
      Location:6267
      RFA2; Single-stranded DNA-binding replication protein A (RPA), medium (30 kD) subunit [DNA replication, recombination, and repair]
      cd04478
      Location:73167
      RPA2_DBD_D; RPA2_DBD_D: A subfamily of OB folds corresponding to the OB fold of the central ssDNA-binding domain (DBD)-D of human RPA2 (also called RPA32). RPA2 is a subunit of Replication protein A (RPA). RPA is a nuclear ssDNA-binding protein (SSB) which appears ...
      pfam08784
      Location:166262
      RPA_C; Replication protein A C terminal

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      132495671..132506057
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)