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    Lrrk2 leucine-rich repeat kinase 2 [ Mus musculus (house mouse) ]

    Gene ID: 66725, updated on 17-Dec-2024

    Summary

    Official Symbol
    Lrrk2provided by MGI
    Official Full Name
    leucine-rich repeat kinase 2provided by MGI
    Primary source
    MGI:MGI:1913975
    See related
    Ensembl:ENSMUSG00000036273 AllianceGenome:MGI:1913975
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm927; cI-46; 4921513O20Rik; 9330188B09Rik; D630001M17Rik
    Summary
    Enables several functions, including beta-catenin destruction complex binding activity; identical protein binding activity; and small GTPase binding activity. Involved in several processes, including positive regulation of catabolic process; regulation of signal transduction; and regulation of vesicle-mediated transport. Acts upstream of or within several processes, including negative regulation of Notch signaling pathway; protein import into nucleus; and protein phosphorylation. Located in several cellular components, including cytoplasmic vesicle; endoplasmic reticulum exit site; and mitochondrion. Part of Wnt signalosome and ribonucleoprotein complex. Is active in glutamatergic synapse and presynaptic cytosol. Is expressed in several structures, including alimentary system; brain; genitourinary system; limb bud; and spinal cord. Used to study Parkinson's disease 8. Human ortholog(s) of this gene implicated in Crohn's disease; Parkinson's disease; Parkinson's disease 8; Parkinsonism; and cancer. Orthologous to human LRRK2 (leucine rich repeat kinase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in kidney adult (RPKM 2.7), lung adult (RPKM 2.3) and 24 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Lrrk2 in Genome Data Viewer
    Location:
    15 E3; 15 46.07 cM
    Exon count:
    53
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (91556994..91700327)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (91672791..91816124)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 2 (facilitated glucose transporter), member 13 Neighboring gene olfactomedin-like 2A pseudogene Neighboring gene tripartite motif-containing 59 pseudogene Neighboring gene STARR-seq mESC enhancer starr_39502 Neighboring gene STARR-positive B cell enhancer ABC_E8606 Neighboring gene STARR-positive B cell enhancer ABC_E4147 Neighboring gene STARR-seq mESC enhancer starr_39505 Neighboring gene STARR-seq mESC enhancer starr_39506 Neighboring gene RAS related protein 1b pseudogene Neighboring gene mucin 19 Neighboring gene submandibular gland protein C

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Items 1 - 25 of 67
    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity  
    enables AMP-activated protein kinase activity  
    enables ATP binding  
    enables DNA-dependent protein kinase activity  
    enables GTP binding PubMed 
    enables GTP-dependent protein kinase activity PubMed 
    enables GTPase activator activity  
    enables GTPase activator activity  
    enables GTPase activity  
    enables JUN kinase kinase kinase activity  
    enables JUN kinase kinase kinase activity  
    enables JUN kinase kinase kinase activity  
    enables MAP kinase kinase kinase activity  
    enables Rho-dependent protein serine/threonine kinase activity  
    enables SNARE binding  
    enables actin binding  
    enables actin binding  
    enables beta-catenin destruction complex binding PubMed 
    enables clathrin binding  
    enables clathrin binding  
    enables eukaryotic translation initiation factor 2alpha kinase activity  
    enables histone H2AS1 kinase activity  
    enables histone H2AS121 kinase activity  
    enables histone H2AT120 kinase activity  
    enables histone H2AXS139 kinase activity  
    enables histone H2BS14 kinase activity  
    enables histone H2BS36 kinase activity  
    enables histone H3S10 kinase activity  
    enables histone H3S28 kinase activity  
    enables histone H3S57 kinase activity  
    enables histone H3T11 kinase activity  
    enables histone H3T3 kinase activity  
    enables histone H3T45 kinase activity  
    enables histone H3T6 kinase activity  
    enables histone H4S1 kinase activity  
    enables identical protein binding PubMed 
    enables identical protein binding  
    enables kinase activity  
    enables kinase activity  
    enables magnesium ion binding  
    enables magnesium ion binding  
    enables membrane scission GTPase motor activity  
    enables peroxidase inhibitor activity  
    enables peroxidase inhibitor activity  
    enables protein binding PubMed 
    enables protein homodimerization activity  
    enables protein homodimerization activity  
    enables protein kinase A binding PubMed 
    enables protein kinase A binding  
    enables protein kinase activity PubMed 
    enables protein kinase activity  
    enables protein serine kinase activity  
    enables protein serine/threonine kinase activity PubMed 
    enables protein serine/threonine kinase activity PubMed 
    enables protein serine/threonine kinase activity  
    enables protein-containing complex binding PubMed 
    enables ribosomal protein S6 kinase activity  
    enables signaling receptor complex adaptor activity PubMed 
    enables signaling receptor complex adaptor activity  
    enables small GTPase binding PubMed 
    enables small GTPase binding  
    enables syntaxin-1 binding  
    enables syntaxin-1 binding  
    enables transmembrane transporter binding  
    enables transmembrane transporter binding  
    enables tubulin binding  
    enables tubulin binding  
    Items 1 - 25 of 67
    Items 1 - 25 of 151
    Process Evidence Code Pubs
    involved_in GTP metabolic process  
    involved_in GTP metabolic process  
    involved_in Golgi organization  
    acts_upstream_of_or_within Golgi organization PubMed 
    involved_in Golgi organization  
    involved_in JNK cascade  
    involved_in JNK cascade  
    involved_in MAPK cascade  
    involved_in Rho protein signal transduction  
    involved_in Rho protein signal transduction  
    involved_in Wnt signalosome assembly PubMed 
    involved_in Wnt signalosome assembly  
    involved_in autophagy  
    involved_in calcium-mediated signaling  
    involved_in calcium-mediated signaling  
    involved_in cellular response to dopamine  
    involved_in cellular response to dopamine  
    involved_in cellular response to manganese ion  
    involved_in cellular response to manganese ion  
    involved_in cellular response to oxidative stress  
    involved_in cellular response to reactive oxygen species  
    involved_in cellular response to reactive oxygen species  
    involved_in cellular response to starvation  
    involved_in cellular response to starvation  
    involved_in chromatin remodeling  
    involved_in determination of adult lifespan  
    involved_in determination of adult lifespan  
    involved_in endocytosis  
    involved_in endocytosis  
    involved_in endoplasmic reticulum organization  
    involved_in endoplasmic reticulum organization PubMed 
    involved_in endoplasmic reticulum organization  
    involved_in excitatory postsynaptic potential PubMed 
    involved_in exploration behavior  
    involved_in intracellular distribution of mitochondria  
    involved_in intracellular distribution of mitochondria  
    involved_in intracellular signal transduction  
    involved_in intracellular signal transduction PubMed 
    involved_in locomotory exploration behavior PubMed 
    involved_in lysosome organization  
    involved_in mitochondrion localization  
    involved_in mitochondrion organization  
    involved_in mitochondrion organization  
    acts_upstream_of_or_within negative regulation of GTPase activity PubMed 
    acts_upstream_of_or_within negative regulation of Notch signaling pathway PubMed 
    involved_in negative regulation of autophagosome assembly  
    involved_in negative regulation of autophagosome assembly  
    involved_in negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway  
    involved_in negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway  
    involved_in negative regulation of excitatory postsynaptic potential PubMed 
    involved_in negative regulation of macroautophagy  
    involved_in negative regulation of neuron projection development  
    involved_in negative regulation of neuron projection development  
    involved_in negative regulation of protein binding  
    involved_in negative regulation of protein processing  
    involved_in negative regulation of protein processing  
    involved_in negative regulation of protein targeting to mitochondrion  
    involved_in negative regulation of protein targeting to mitochondrion  
    involved_in negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation  
    involved_in neuromuscular junction development  
    involved_in neuromuscular junction development  
    acts_upstream_of_or_within neuron differentiation PubMed 
    involved_in neuron projection arborization  
    involved_in neuron projection arborization  
    involved_in neuron projection morphogenesis  
    involved_in neuron projection morphogenesis  
    involved_in olfactory bulb development  
    involved_in peptidyl-serine phosphorylation  
    involved_in peptidyl-threonine phosphorylation  
    involved_in phosphorylation  
    involved_in positive regulation of MAP kinase activity  
    involved_in positive regulation of autophagy  
    involved_in positive regulation of autophagy PubMed 
    involved_in positive regulation of autophagy  
    involved_in positive regulation of canonical Wnt signaling pathway  
    involved_in positive regulation of canonical Wnt signaling pathway  
    involved_in positive regulation of dopamine receptor signaling pathway  
    involved_in positive regulation of dopamine receptor signaling pathway  
    involved_in positive regulation of microglial cell activation  
    involved_in positive regulation of microglial cell activation  
    involved_in positive regulation of programmed cell death  
    involved_in positive regulation of programmed cell death  
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process PubMed 
    involved_in positive regulation of protein autoubiquitination  
    involved_in positive regulation of protein autoubiquitination  
    involved_in positive regulation of protein binding  
    involved_in positive regulation of protein kinase activity  
    involved_in positive regulation of protein phosphorylation  
    involved_in positive regulation of protein ubiquitination  
    involved_in positive regulation of synaptic vesicle endocytosis  
    involved_in positive regulation of synaptic vesicle endocytosis  
    involved_in positive regulation of tumor necrosis factor production  
    involved_in positive regulation of tumor necrosis factor production  
    acts_upstream_of_or_within protein autophosphorylation PubMed 
    involved_in protein autophosphorylation  
    acts_upstream_of_or_within protein import into nucleus PubMed 
    acts_upstream_of_or_within protein import into nucleus PubMed 
    involved_in protein localization PubMed 
    involved_in protein localization to endoplasmic reticulum exit site PubMed 
    involved_in protein localization to endoplasmic reticulum exit site  
    acts_upstream_of_or_within protein phosphorylation PubMed 
    acts_upstream_of_or_within protein phosphorylation PubMed 
    involved_in protein phosphorylation PubMed 
    acts_upstream_of_or_within protein phosphorylation PubMed 
    involved_in protein phosphorylation  
    involved_in regulation of CAMKK-AMPK signaling cascade  
    involved_in regulation of CAMKK-AMPK signaling cascade  
    involved_in regulation of ER to Golgi vesicle-mediated transport PubMed 
    involved_in regulation of autophagy  
    involved_in regulation of branching morphogenesis of a nerve  
    involved_in regulation of branching morphogenesis of a nerve  
    involved_in regulation of cAMP/PKA signal transduction PubMed 
    involved_in regulation of canonical Wnt signaling pathway  
    involved_in regulation of canonical Wnt signaling pathway PubMed 
    involved_in regulation of cell projection organization  
    involved_in regulation of dendritic spine morphogenesis PubMed 
    involved_in regulation of dendritic spine morphogenesis  
    involved_in regulation of dopamine receptor signaling pathway  
    involved_in regulation of dopamine receptor signaling pathway PubMed 
    acts_upstream_of_or_within regulation of gene expression PubMed 
    involved_in regulation of kidney size PubMed 
    involved_in regulation of locomotion  
    involved_in regulation of locomotion  
    involved_in regulation of lysosomal lumen pH  
    involved_in regulation of lysosomal lumen pH  
    involved_in regulation of membrane potential  
    involved_in regulation of mitochondrial depolarization  
    involved_in regulation of mitochondrial depolarization  
    involved_in regulation of neuroblast proliferation  
    involved_in regulation of neuroblast proliferation  
    involved_in regulation of neuron maturation  
    involved_in regulation of neuron maturation  
    involved_in regulation of protein stability  
    involved_in regulation of protein stability  
    involved_in regulation of reactive oxygen species metabolic process  
    involved_in regulation of reactive oxygen species metabolic process  
    involved_in regulation of retrograde transport, endosome to Golgi  
    involved_in regulation of retrograde transport, endosome to Golgi  
    involved_in regulation of synaptic transmission, glutamatergic PubMed 
    involved_in regulation of synaptic vesicle endocytosis  
    involved_in regulation of synaptic vesicle endocytosis PubMed 
    involved_in regulation of synaptic vesicle endocytosis PubMed 
    involved_in regulation of synaptic vesicle exocytosis  
    involved_in regulation of synaptic vesicle exocytosis  
    involved_in regulation of synaptic vesicle transport PubMed 
    involved_in response to oxidative stress  
    involved_in spermatogenesis  
    involved_in striatum development  
    involved_in synaptic vesicle recycling PubMed 
    involved_in tangential migration from the subventricular zone to the olfactory bulb  
    involved_in tangential migration from the subventricular zone to the olfactory bulb  
    Items 1 - 25 of 151
    Items 1 - 20 of 64
    Component Evidence Code Pubs
    located_in Golgi apparatus PubMed 
    located_in Golgi apparatus  
    located_in Golgi membrane  
    located_in Golgi-associated vesicle  
    located_in Golgi-associated vesicle  
    part_of Wnt signalosome PubMed 
    part_of Wnt signalosome  
    located_in amphisome  
    located_in amphisome  
    located_in autolysosome  
    located_in autolysosome  
    located_in axon  
    located_in axon  
    located_in caveola neck  
    located_in caveola neck  
    is_active_in cytoplasm  
    located_in cytoplasm PubMed 
    located_in cytoplasm  
    located_in cytoplasmic side of mitochondrial outer membrane  
    located_in cytoplasmic side of mitochondrial outer membrane  
    located_in cytoplasmic vesicle PubMed 
    located_in cytoskeleton  
    located_in cytosol PubMed 
    located_in dendrite PubMed 
    located_in dendrite  
    located_in dendrite cytoplasm  
    located_in dendrite cytoplasm  
    located_in endoplasmic reticulum PubMed 
    located_in endoplasmic reticulum  
    located_in endoplasmic reticulum exit site PubMed 
    located_in endoplasmic reticulum exit site  
    located_in endoplasmic reticulum membrane  
    located_in endosome PubMed 
    is_active_in glutamatergic synapse PubMed 
    is_active_in glutamatergic synapse PubMed 
    located_in growth cone  
    located_in growth cone  
    located_in intracellular membrane-bounded organelle  
    located_in lysosome PubMed 
    located_in membrane raft PubMed 
    located_in microvillus  
    located_in microvillus  
    located_in mitochondrial inner membrane PubMed 
    located_in mitochondrial matrix PubMed 
    located_in mitochondrial membrane  
    located_in mitochondrial outer membrane PubMed 
    located_in mitochondrion  
    located_in multivesicular body, internal vesicle  
    located_in multivesicular body, internal vesicle  
    located_in neuron projection  
    located_in neuronal cell body  
    located_in perikaryon  
    located_in perikaryon  
    located_in phagocytic vesicle  
    located_in plasma membrane PubMed 
    located_in plasma membrane  
    located_in postsynapse  
    is_active_in presynaptic cytosol PubMed 
    part_of ribonucleoprotein complex PubMed 
    located_in synapse PubMed 
    located_in synaptic vesicle PubMed 
    located_in synaptic vesicle membrane  
    located_in terminal bouton PubMed 
    located_in trans-Golgi network PubMed 
    Items 1 - 20 of 64

    General protein information

    Preferred Names
    leucine-rich repeat serine/threonine-protein kinase 2
    NP_080006.3
    XP_006521340.1
    XP_036015439.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025730.3NP_080006.3  leucine-rich repeat serine/threonine-protein kinase 2

      See identical proteins and their annotated locations for NP_080006.3

      Status: VALIDATED

      Source sequence(s)
      AC099704, AC158752, AK014886, AK014938, AK034413, AK050702, AK052591, BF660966
      Consensus CDS
      CCDS37180.1
      UniProtKB/Swiss-Prot
      E9QNJ2, Q5S006, Q8BWG7, Q8BZJ6, Q8CI84, Q8K062
      Related
      ENSMUSP00000052584.7, ENSMUST00000060642.7
      Conserved Domains (6) summary
      cd09914
      Location:13341507
      RocCOR; Ras of complex proteins (Roc) C-terminal of Roc (COR) domain family
      smart00220
      Location:18842128
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      COG1100
      Location:13331551
      Gem1; GTPase SAR1 family domain [General function prediction only]
      cd14068
      Location:18842135
      STKc_LRRK2; Catalytic domain of the Serine/Threonine Kinase, Leucine-Rich Repeat Kinase 2
      sd00033
      Location:10131036
      LRR_RI; leucine-rich repeat [structural motif]
      pfam16095
      Location:15271740
      COR; C-terminal of Roc, COR, domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      91556994..91700327
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006521277.5XP_006521340.1  leucine-rich repeat serine/threonine-protein kinase 2 isoform X2

      Conserved Domains (5) summary
      PRK15370
      Location:10141290
      PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
      cd09914
      Location:13341507
      RocCOR; Ras of complex proteins (Roc) C-terminal of Roc (COR) domain family
      sd00033
      Location:10131036
      LRR_RI; leucine-rich repeat [structural motif]
      pfam16095
      Location:15271740
      COR; C-terminal of Roc, COR, domain
      cl21453
      Location:18842036
      PKc_like; Protein Kinases, catalytic domain
    2. XM_036159546.1XP_036015439.1  leucine-rich repeat serine/threonine-protein kinase 2 isoform X1

      Conserved Domains (5) summary
      PRK15370
      Location:9691245
      PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
      cd09914
      Location:12891462
      RocCOR; Ras of complex proteins (Roc) C-terminal of Roc (COR) domain family
      cd14068
      Location:18392090
      STKc_LRRK2; Catalytic domain of the Serine/Threonine Kinase, Leucine-Rich Repeat Kinase 2
      sd00033
      Location:968991
      LRR_RI; leucine-rich repeat [structural motif]
      pfam16095
      Location:14821695
      COR; C-terminal of Roc, COR, domain

    RNA

    1. XR_004938860.1 RNA Sequence

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