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    Pramel3a PRAME like 3A [ Mus musculus (house mouse) ]

    Gene ID: 83565, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pramel3aprovided by MGI
    Official Full Name
    PRAME like 3Aprovided by MGI
    Primary source
    MGI:MGI:1890657
    See related
    Ensembl:ENSMUSG00000067360 AllianceGenome:MGI:1890657
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pramel3
    Summary
    Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be part of Cul2-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. Is expressed in germ cell of testis; ovary; primary sex cord; and testis. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward testis adult (RPKM 3.0) See more
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    Genomic context

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    See Pramel3a in Genome Data Viewer
    Location:
    X F1; X 56.84 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (134203039..134213385)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (135302289..135312636)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene crumbs homolog 1 pseudogene Neighboring gene PRAME like, X-linked 2 Neighboring gene predicted gene, 25936 Neighboring gene predicted pseudogene 6215

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Differential expression of sex-linked and autosomal germ-cell-specific genes during spermatogenesis in the mouse. Wang PJ, et al. Hum Mol Genet, 2005 Oct 1. PMID 16118233, Free PMC Article
    2. Polycomb protein SCML2 associates with USP7 and counteracts histone H2A ubiquitination in the XY chromatin during male meiosis. Luo M, et al. PLoS Genet, 2015 Jan. PMID 25634095, Free PMC Article
    3. Hormad1 mutation disrupts synaptonemal complex formation, recombination, and chromosome segregation in mammalian meiosis. Shin YH, et al. PLoS Genet, 2010 Nov 4. PMID 21079677, Free PMC Article
    4. Genomewide discovery and classification of candidate ovarian fertility genes in the mouse. Gallardo TD, et al. Genetics, 2007 Sep. PMID 17660561, Free PMC Article
    5. A 1.1-Mb segmental deletion on the X chromosome causes meiotic failure in male mice. Zhou J, et al. Biol Reprod, 2013 Jun. PMID 23677977, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Pramel3 is a gene that is expressed in testis that was identified in a genome-wide cDNA subtraction screen.
      Title: An abundance of X-linked genes expressed in spermatogonia.
    2. Pramel3 is found within a region of the X chromosome, that when deleted as part of a 1.1 Mb segmental deletion, causes meiotic failure in male mice.
      Title: A 1.1-Mb segmental deletion on the X chromosome causes meiotic failure in male mice.
    3. Germ-cell-specific sex-linked genes, like Pramel3, are subject to meiotic sex-chromosome inactivation (MSCI) during spermatogenesis.
      Title: Differential expression of sex-linked and autosomal germ-cell-specific genes during spermatogenesis in the mouse.
    4. Transcripts highly enriched in ovary; gene identified as candidate female fertility factor.
      Title: Genomewide discovery and classification of candidate ovarian fertility genes in the mouse.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    preferentially expressed antigen in melanoma-like 3
    Names
    PRAME like 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031390.2 → NP_113567.1  preferentially expressed antigen in melanoma-like 3

      See identical proteins and their annotated locations for NP_113567.1

      Status: VALIDATED

      Source sequence(s)
      AL731676
      Consensus CDS
      CCDS30403.1
      UniProtKB/TrEMBL
      A2AHA7, Q8C0W2, Q99M97
      Related
      ENSMUSP00000112761.3, ENSMUST00000118821.8
      Conserved Domains (1) summary
      sd00033
      Location:242 → 272
      LRR_RI; leucine-rich repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      134203039..134213385
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006528634.3 → XP_006528697.1  preferentially expressed antigen in melanoma-like 3 isoform X1

      See identical proteins and their annotated locations for XP_006528697.1

      UniProtKB/TrEMBL
      Q8C0W2
      Conserved Domains (1) summary
      sd00033
      Location:243 → 273
      LRR_RI; leucine-rich repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version

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