Cry2 cryptochrome circadian regulator 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cry2provided by MGI
Official Full Name: cryptochrome circadian regulator 2provided by MGI
Primary source: MGI:MGI:1270859
See related: Ensembl:ENSMUSG00000068742 AllianceGenome:MGI:1270859
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: D130054K12Rik
Summary: This gene encodes a flavin adenine dinucleotide-binding protein that is a key component of the circadian core oscillator complex, which regulates the circadian clock. This gene is upregulated by Clock/Arntl heterodimers but then represses this upregulation in a feedback loop using Per/Cry heterodimers to interact with Clock/Arntl. Polymorphisms in this gene have been associated with altered sleep patterns. The encoded protein is widely conserved across plants and animals. [provided by RefSeq, Feb 2014]
Expression: Ubiquitous expression in cortex adult (RPKM 22.9), frontal lobe adult (RPKM 22.1) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2; 2 E1

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (92233991..92264426, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (92403646..92434085, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CRY2 mediates the cognitive decline induced by sleep deprivation in 5xFAD mice.
Title: CRY2 mediates the cognitive decline induced by sleep deprivation in 5xFAD mice.
Functional characterization of the CRY2 circadian clock component variant p.Ser420Phe revealed a new degradation pathway for CRY2.
Title: Functional characterization of the CRY2 circadian clock component variant p.Ser420Phe revealed a new degradation pathway for CRY2.
CRY1/2 regulate rhythmic CYP2A5 in mouse liver through repression of E4BP4.
Title: CRY1/2 regulate rhythmic CYP2A5 in mouse liver through repression of E4BP4.
CircZNF367 promotes osteoclast differentiation and osteoporosis by interacting with FUS to maintain CRY2 mRNA stability.
Title: CircZNF367 promotes osteoclast differentiation and osteoporosis by interacting with FUS to maintain CRY2 mRNA stability.
The secondary pocket of cryptochrome 2 is important for the regulation of its stability and localization.
Title: The secondary pocket of cryptochrome 2 is important for the regulation of its stability and localization.
Role of heterozygous and homozygous alleles in cryptochrome-deficient mice.
Title: Role of heterozygous and homozygous alleles in cryptochrome-deficient mice.
CRY2 missense mutations suppress P53 and enhance cell growth.
Title: CRY2 missense mutations suppress P53 and enhance cell growth.
Structural differences in the FAD-binding pockets and lid loops of mammalian CRY1 and CRY2 for isoform-selective regulation.
Title: Structural differences in the FAD-binding pockets and lid loops of mammalian CRY1 and CRY2 for isoform-selective regulation.
Restoring the Molecular Clockwork within the Suprachiasmatic Hypothalamus of an Otherwise Clockless Mouse Enables Circadian Phasing and Stabilization of Sleep-Wake Cycles and Reverses Memory Deficits.
Title: Restoring the Molecular Clockwork within the Suprachiasmatic Hypothalamus of an Otherwise Clockless Mouse Enables Circadian Phasing and Stabilization of Sleep-Wake Cycles and Reverses Memory Deficits.
CRYPTOCHROMES confer robustness, not rhythmicity, to circadian timekeeping.
Title: CRYPTOCHROMES confer robustness, not rhythmicity, to circadian timekeeping.

Submit: New GeneRIF Correction See all GeneRIFs (74)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5)
Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BE118974 (e-PCR)
- UniSTS:248915

NoName (e-PCR)
- UniSTS:491930

D2Mit302 (e-PCR), detects polymorphism
- UniSTS:129192

Cry2 (e-PCR), detects polymorphism
- UniSTS:532165

Cry2 (e-PCR), detects polymorphism
- UniSTS:506822

AV006279 (e-PCR)
- UniSTS:178654

NoName (e-PCR)
- UniSTS:234467

BB392026 (e-PCR)
- UniSTS:207353

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables FAD binding	IBA Inferred from Biological aspect of Ancestor more info
enables FAD binding	IDA Inferred from Direct Assay more info	PubMed
enables damaged DNA binding	IEA Inferred from Electronic Annotation more info
enables damaged DNA binding	ISO Inferred from Sequence Orthology more info
enables kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables nuclear receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables phosphatase binding	IEA Inferred from Electronic Annotation more info
enables phosphatase binding	ISO Inferred from Sequence Orthology more info
enables photoreceptor activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein phosphatase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables single-stranded DNA binding	IEA Inferred from Electronic Annotation more info
enables single-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables transcription cis-regulatory region binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in circadian regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info
involved_in circadian regulation of gene expression	IGI Inferred from Genetic Interaction more info	PubMed
involved_in circadian regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in circadian regulation of gene expression	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within circadian rhythm	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in circadian rhythm	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in entrainment of circadian clock by photoperiod	IBA Inferred from Biological aspect of Ancestor more info
involved_in entrainment of circadian clock by photoperiod	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glucose homeostasis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in lipid storage	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of DNA-templated transcription	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of circadian rhythm	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of circadian rhythm	NAS Non-traceable Author Statement more info	PubMed
involved_in negative regulation of glucocorticoid receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of glucocorticoid secretion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein import into nucleus	IPI Inferred from Physical Interaction more info	PubMed
involved_in regulation of circadian rhythm	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of sodium-dependent phosphate transport	IEA Inferred from Electronic Annotation more info
involved_in response to activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to insulin	IGI Inferred from Genetic Interaction more info	PubMed
involved_in response to light stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to light stimulus	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of Cry-Per complex	IPI Inferred from Physical Interaction more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	TAS Traceable Author Statement more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear speck	IEA Inferred from Electronic Annotation more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: cryptochrome-2

Names: cryptochrome 2 (photolyase-like)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_009963.4 → NP_034093.1 cryptochrome-2

See identical proteins and their annotated locations for NP_034093.1

Status: VALIDATED

Source sequence(s)

AK172994, BC054794, CJ164467

Consensus CDS

CCDS16447.1

UniProtKB/Swiss-Prot

O08706, Q6A024, Q9R194

Related

ENSMUSP00000088047.6, ENSMUST00000090559.12

Conserved Domains (2) summary

COG0415
Location:21 → 509

PhrB; Deoxyribodipyrimidine photolyase [Replication, recombination and repair]

pfam03441
Location:306 → 504

FAD_binding_7; FAD binding domain of DNA photolyase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

92233991..92264426 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030247073.1 → XP_030102933.1 cryptochrome-2 isoform X2

Conserved Domains (1) summary

pfam03441
Location:129 → 327

FAD_binding_7; FAD binding domain of DNA photolyase
XM_017315281.3 → XP_017170770.1 cryptochrome-2 isoform X1

UniProtKB/Swiss-Prot

O08706, Q6A024, Q9R194

Related

ENSMUSP00000106909.2, ENSMUST00000111278.2

Conserved Domains (2) summary

COG0415
Location:21 → 509

PhrB; Deoxyribodipyrimidine photolyase [Replication, recombination and repair]

pfam03441
Location:306 → 504

FAD_binding_7; FAD binding domain of DNA photolyase

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001113333.1: Suppressed sequence

Description

NM_001113333.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.