Nlrc4 NLR family, CARD domain containing 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nlrc4provided by MGI
Official Full Name: NLR family, CARD domain containing 4provided by MGI
Primary source: MGI:MGI:3036243
See related: Ensembl:ENSMUSG00000039193 AllianceGenome:MGI:3036243
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CLAN; IPAF; CLAN1; CLANA; CLANB; CLANC; CLAND; Card12; 9530011P19Rik
Summary: Enables identical protein binding activity. Involved in several processes, including positive regulation of interleukin-1 beta production; pyroptotic inflammatory response; and response to bacterium. Acts upstream of or within regulation of apoptotic process and regulation of cysteine-type endopeptidase activity involved in apoptotic process. Located in cytosol. Part of IPAF inflammasome complex. Used to study familial cold autoinflammatory syndrome 4. Human ortholog(s) of this gene implicated in familial cold autoinflammatory syndrome 4. Orthologous to human NLRC4 (NLR family CARD domain containing 4). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in large intestine adult (RPKM 5.3), small intestine adult (RPKM 2.0) and 5 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 E2; 17 45.64 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (74733254..74766140, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (74426255..74459144, complement)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Atg16l2 augments Nlrc4 inflammasome activation by facilitating NAIPs-NLRC4 association.
Title: Atg16l2 augments Nlrc4 inflammasome activation by facilitating NAIPs-NLRC4 association.
NLRC4-mediated pyroptosis was involved in coagulation disorders of acute pancreatitis.
Title: NLRC4-mediated pyroptosis was involved in coagulation disorders of acute pancreatitis.
Formylpeptide receptor 1 contributes to epidermal barrier dysfunction-induced skin inflammation through NOD-like receptor C4-dependent keratinocyte activation.
Title: Formylpeptide receptor 1 contributes to epidermal barrier dysfunction-induced skin inflammation through NOD-like receptor C4-dependent keratinocyte activation.
Targeting Desulfovibrio vulgaris flagellin-induced NAIP/NLRC4 inflammasome activation in macrophages attenuates ulcerative colitis.
Title: Targeting Desulfovibrio vulgaris flagellin-induced NAIP/NLRC4 inflammasome activation in macrophages attenuates ulcerative colitis.
FlgM is required to evade NLRC4-mediated host protection against flagellated Salmonella.
Title: FlgM is required to evade NLRC4-mediated host protection against flagellated Salmonella.
NLRC4 promotes the cGAS-STING signaling pathway by facilitating CBL-mediated K63-linked polyubiquitination of TBK1.
Title: NLRC4 promotes the cGAS-STING signaling pathway by facilitating CBL-mediated K63-linked polyubiquitination of TBK1.
LNCGM1082-mediated NLRC4 activation drives resistance to bacterial infection.
Title: LNCGM1082-mediated NLRC4 activation drives resistance to bacterial infection.
Inflammasome activation and CCR2-mediated monocyte-derived dendritic cell recruitment restrict Legionella pneumophila infection.
Title: Inflammasome activation and CCR2-mediated monocyte-derived dendritic cell recruitment restrict Legionella pneumophila infection.
Vitamin D receptor enhances NLRC4 inflammasome activation by promoting NAIPs-NLRC4 association.
Title: Vitamin D receptor enhances NLRC4 inflammasome activation by promoting NAIPs-NLRC4 association.
LCN2 Mediates Skin Inflammation in Psoriasis through the SREBP2NLRC4 Axis.
Title: LCN2 Mediates Skin Inflammation in Psoriasis through the SREBP2‒NLRC4 Axis.

Submit: New GeneRIF Correction See all GeneRIFs (88)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1)
Endonuclease-mediated (11) 1 citation
Targeted (6) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables ATP binding	ISS Inferred from Sequence or Structural Similarity more info
enables caspase binding	ISO Inferred from Sequence Orthology more info
enables endopeptidase activator activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in activation of cysteine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info
involved_in activation of innate immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in defense response to bacterium	IBA Inferred from Biological aspect of Ancestor more info
involved_in defense response to bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to bacterium	ISO Inferred from Sequence Orthology more info
involved_in defense response to bacterium	ISS Inferred from Sequence or Structural Similarity more info
involved_in detection of bacterium	IBA Inferred from Biological aspect of Ancestor more info
involved_in detection of bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in detection of bacterium	ISO Inferred from Sequence Orthology more info
involved_in detection of bacterium	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-1 beta production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of interleukin-1 beta production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein processing	ISO Inferred from Sequence Orthology more info
involved_in protein homooligomerization	IDA Inferred from Direct Assay more info	PubMed
involved_in pyroptotic inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of cysteine-type endopeptidase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of IPAF inflammasome complex	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	TAS Traceable Author Statement more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: NLR family CARD domain-containing protein 4

Names: caspase recruitment domain family, member 12; caspase recruitment domain-containing protein 12; ice protease-activating factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001033367.3 → NP_001028539.1 NLR family CARD domain-containing protein 4

See identical proteins and their annotated locations for NP_001028539.1

Status: VALIDATED

Source sequence(s)

CT033749

Consensus CDS

CCDS37692.1

UniProtKB/Swiss-Prot

Q3TAU8, Q3UP24

UniProtKB/TrEMBL

A0A3Q4EGE7

Related

ENSMUSP00000059637.8, ENSMUST00000052124.9

Conserved Domains (6) summary

COG5635
Location:166 → 465

COG5635; Predicted NTPase, NACHT family domain [Signal transduction mechanisms]

sd00034
Location:664 → 689

LRR_AMN1; leucine-rich repeat [structural motif]

pfam00619
Location:1 → 87

CARD; Caspase recruitment domain

pfam05729
Location:163 → 310

NACHT; NACHT domain

pfam17889
Location:465 → 579

NLRC4_HD; NLRC4 helical domain

cl39015
Location:755 → 871

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

74733254..74766140 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006524346.5 → XP_006524409.1 NLR family CARD domain-containing protein 4 isoform X1

See identical proteins and their annotated locations for XP_006524409.1

UniProtKB/Swiss-Prot

Q3TAU8, Q3UP24

UniProtKB/TrEMBL

A0A3Q4EGE7

Conserved Domains (6) summary

COG5635
Location:166 → 465

COG5635; Predicted NTPase, NACHT family domain [Signal transduction mechanisms]

sd00034
Location:664 → 689

LRR_AMN1; leucine-rich repeat [structural motif]

pfam00619
Location:1 → 87

CARD; Caspase recruitment domain

pfam05729
Location:163 → 310

NACHT; NACHT domain

pfam17889
Location:465 → 579

NLRC4_HD; NLRC4 helical domain

cl39015
Location:755 → 871

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
XM_006524347.5 → XP_006524410.1 NLR family CARD domain-containing protein 4 isoform X2

UniProtKB/TrEMBL

A0A3Q4EGE7

Conserved Domains (6) summary

COG5635
Location:28 → 327

COG5635; Predicted NTPase, NACHT family domain [Signal transduction mechanisms]

sd00033
Location:715 → 742

LRR_RI; leucine-rich repeat [structural motif]

sd00034
Location:526 → 551

LRR_AMN1; leucine-rich repeat [structural motif]

pfam05729
Location:25 → 172

NACHT; NACHT domain

pfam17889
Location:327 → 441

NLRC4_HD; NLRC4 helical domain

cl39015
Location:617 → 733

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
XM_017317491.2 → XP_017172980.1 NLR family CARD domain-containing protein 4 isoform X1

UniProtKB/Swiss-Prot

Q3TAU8, Q3UP24

UniProtKB/TrEMBL

A0A3Q4EGE7

Conserved Domains (6) summary

COG5635
Location:166 → 465

COG5635; Predicted NTPase, NACHT family domain [Signal transduction mechanisms]

sd00034
Location:664 → 689

LRR_AMN1; leucine-rich repeat [structural motif]

pfam00619
Location:1 → 87

CARD; Caspase recruitment domain

pfam05729
Location:163 → 310

NACHT; NACHT domain

pfam17889
Location:465 → 579

NLRC4_HD; NLRC4 helical domain

cl39015
Location:755 → 871

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...