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    Chrna7 cholinergic receptor, nicotinic, alpha polypeptide 7 [ Mus musculus (house mouse) ]

    Gene ID: 11441, updated on 10-Dec-2024

    Summary

    Official Symbol
    Chrna7provided by MGI
    Official Full Name
    cholinergic receptor, nicotinic, alpha polypeptide 7provided by MGI
    Primary source
    MGI:MGI:99779
    See related
    Ensembl:ENSMUSG00000030525 AllianceGenome:MGI:99779
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Acra7; nAchR; alpha7
    Summary
    Enables acetylcholine-gated monoatomic cation-selective channel activity. Involved in several processes, including plasma membrane bounded cell projection organization; positive regulation of cell communication; and regulation of protein metabolic process. Acts upstream of or within several processes, including behavioral response to ethanol; learning or memory; and negative regulation of cytokine production. Located in apical plasma membrane; axolemma; and external side of plasma membrane. Is active in cholinergic synapse; postsynaptic specialization membrane; and presynaptic membrane. Is expressed in several structures, including adrenal gland; alimentary system; nervous system; retina; and thymus. Used to study schizophrenia. Human ortholog(s) of this gene implicated in chronic obstructive pulmonary disease; esophagus squamous cell carcinoma; respiratory system cancer (multiple); and schizophrenia. Orthologous to human CHRFAM7A (CHRNA7 (exons 5-10) and FAM7A (exons A-E) fusion) and CHRNA7 (cholinergic receptor nicotinic alpha 7 subunit). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in adrenal adult (RPKM 6.7), CNS E18 (RPKM 3.8) and 10 other tissues See more
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    Genomic context

    See Chrna7 in Genome Data Viewer
    Location:
    7 C; 7 34.47 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (62748440..62862274, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (63098692..63212526, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene perilipin 3 pseudogene Neighboring gene POTE ankyrin domain family member 2 Neighboring gene predicted gene 5333 Neighboring gene STARR-seq mESC enhancer starr_19001 Neighboring gene STARR-seq mESC enhancer starr_19002 Neighboring gene RIKEN cDNA 4930554H23 gene Neighboring gene OTU domain containing 7A Neighboring gene thyroid hormone receptor associated protein 3 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 
    • Targeted (10)  1 citation

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATPase binding  
    enables acetylcholine binding  
    enables acetylcholine receptor activity  
    enables acetylcholine-gated monoatomic cation-selective channel activity  
    enables acetylcholine-gated monoatomic cation-selective channel activity PubMed 
    enables acetylcholine-gated monoatomic cation-selective channel activity PubMed 
    enables acetylcholine-gated monoatomic cation-selective channel activity  
    enables adenylate cyclase binding  
    enables amyloid-beta binding  
    enables chloride channel regulator activity  
    enables monoatomic ion channel activity  
    enables protein binding PubMed 
    enables protein homodimerization activity  
    enables protein kinase binding  
    enables scaffold protein binding  
    enables toxic substance binding  
    enables transmembrane signaling receptor activity  
    enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential  
    Items 1 - 25 of 77
    Process Evidence Code Pubs
    acts_upstream_of_or_within B cell activation PubMed 
    acts_upstream_of_or_within T cell activation PubMed 
    involved_in acetylcholine receptor signaling pathway  
    acts_upstream_of_or_within associative learning PubMed 
    acts_upstream_of_or_within associative learning PubMed 
    acts_upstream_of_or_within behavioral response to ethanol PubMed 
    acts_upstream_of_or_within behavioral response to nicotine PubMed 
    acts_upstream_of_or_within calcium ion transport  
    involved_in chemical synaptic transmission  
    involved_in dendrite arborization PubMed 
    involved_in dendritic spine organization PubMed 
    acts_upstream_of_or_within endocytosis PubMed 
    acts_upstream_of_or_within establishment of localization in cell PubMed 
    involved_in excitatory postsynaptic potential  
    acts_upstream_of_or_within flagellated sperm motility PubMed 
    acts_upstream_of_or_within generation of ovulation cycle rhythm PubMed 
    acts_upstream_of interleukin-1 beta production PubMed 
    acts_upstream_of interleukin-6 production PubMed 
    involved_in learning or memory PubMed 
    involved_in learning or memory  
    acts_upstream_of_or_within memory PubMed 
    involved_in memory  
    involved_in modulation of chemical synaptic transmission PubMed 
    involved_in modulation of excitatory postsynaptic potential PubMed 
    involved_in modulation of excitatory postsynaptic potential PubMed 
    involved_in monoatomic ion transmembrane transport  
    involved_in monoatomic ion transmembrane transport  
    involved_in monoatomic ion transmembrane transport  
    acts_upstream_of_or_within monoatomic ion transport PubMed 
    involved_in negative regulation of ERK1 and ERK2 cascade  
    acts_upstream_of_or_within negative regulation of inflammatory response PubMed 
    acts_upstream_of_or_within negative regulation of interleukin-1 beta production PubMed 
    acts_upstream_of_or_within negative regulation of interleukin-6 production PubMed 
    involved_in negative regulation of protein phosphorylation PubMed 
    acts_upstream_of_or_within negative regulation of tumor necrosis factor production PubMed 
    acts_upstream_of_or_within negative regulation of tumor necrosis factor production  
    involved_in neuronal action potential  
    acts_upstream_of_or_within ovulation cycle PubMed 
    involved_in positive regulation of CoA-transferase activity PubMed 
    involved_in positive regulation of ERK1 and ERK2 cascade PubMed 
    involved_in positive regulation of ERK1 and ERK2 cascade PubMed 
    involved_in positive regulation of ERK1 and ERK2 cascade PubMed 
    involved_in positive regulation of ERK1 and ERK2 cascade  
    involved_in positive regulation of amyloid-beta formation PubMed 
    involved_in positive regulation of excitatory postsynaptic potential PubMed 
    involved_in positive regulation of gene expression  
    acts_upstream_of_or_within positive regulation of heart rate involved in baroreceptor response to decreased systemic arterial blood pressure PubMed 
    involved_in positive regulation of long-term synaptic potentiation PubMed 
    involved_in positive regulation of long-term synaptic potentiation PubMed 
    involved_in positive regulation of peptidyl-serine phosphorylation PubMed 
    involved_in positive regulation of protein metabolic process PubMed 
    involved_in positive regulation of protein phosphorylation PubMed 
    involved_in presynaptic modulation of chemical synaptic transmission  
    involved_in regulation of amyloid fibril formation PubMed 
    acts_upstream_of_or_within regulation of inflammatory response PubMed 
    involved_in regulation of membrane potential  
    acts_upstream_of_or_within regulation of membrane potential PubMed 
    acts_upstream_of_or_within regulation of membrane potential  
    acts_upstream_of_or_within regulation of norepinephrine secretion PubMed 
    involved_in regulation of response to drug  
    involved_in regulation of synapse structural plasticity PubMed 
    acts_upstream_of_or_within regulation of synaptic transmission, dopaminergic PubMed 
    involved_in response to acetylcholine  
    involved_in response to amyloid-beta PubMed 
    involved_in response to cold PubMed 
    acts_upstream_of_or_within response to ethanol PubMed 
    acts_upstream_of_or_within response to food PubMed 
    involved_in response to nicotine PubMed 
    acts_upstream_of_or_within response to nicotine PubMed 
    involved_in response to nicotine  
    involved_in sensory processing PubMed 
    involved_in sensory processing  
    involved_in synapse organization PubMed 
    involved_in synaptic transmission, cholinergic PubMed 
    acts_upstream_of_or_within synaptic transmission, cholinergic PubMed 
    involved_in synaptic transmission, cholinergic  
    acts_upstream_of tumor necrosis factor production PubMed 
    Items 1 - 25 of 77
    Items 1 - 20 of 32
    Component Evidence Code Pubs
    part_of acetylcholine-gated channel complex  
    part_of acetylcholine-gated channel complex  
    located_in apical plasma membrane PubMed 
    located_in asymmetric synapse  
    located_in axolemma PubMed 
    located_in axon  
    is_active_in cholinergic synapse PubMed 
    is_active_in cholinergic synapse  
    located_in dendrite  
    located_in dendritic shaft  
    located_in dendritic spine  
    located_in external side of plasma membrane PubMed 
    is_active_in glycinergic synapse  
    located_in growth cone  
    located_in membrane PubMed 
    is_active_in neuron projection  
    located_in neuronal cell body  
    is_active_in plasma membrane  
    located_in plasma membrane  
    located_in plasma membrane raft  
    is_active_in postsynaptic membrane PubMed 
    is_active_in postsynaptic membrane PubMed 
    is_active_in postsynaptic membrane  
    is_active_in postsynaptic specialization membrane PubMed 
    is_active_in postsynaptic specialization membrane  
    located_in presynapse PubMed 
    is_active_in presynaptic membrane PubMed 
    is_active_in presynaptic membrane PubMed 
    is_active_in presynaptic membrane  
    located_in presynaptic membrane  
    is_active_in spine apparatus membrane  
    is_active_in synapse  
    Items 1 - 20 of 32

    General protein information

    Preferred Names
    neuronal acetylcholine receptor subunit alpha-7
    Names
    acetylcholine receptor alpha 7 neural
    alpha7 nicotinic receptor
    alpha7-nAChR

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007390.3NP_031416.3  neuronal acetylcholine receptor subunit alpha-7 precursor

      See identical proteins and their annotated locations for NP_031416.3

      Status: VALIDATED

      Source sequence(s)
      AK034208, AK157809, BY727569
      Consensus CDS
      CCDS21329.1
      UniProtKB/Swiss-Prot
      P49582
      UniProtKB/TrEMBL
      Q53YJ9, Q9JHD6
      Related
      ENSMUSP00000032738.6, ENSMUST00000032738.7
      Conserved Domains (3) summary
      TIGR00860
      Location:4490
      LIC; Cation transporter family protein
      pfam02931
      Location:26230
      Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
      pfam02932
      Location:237486
      Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      62748440..62862274 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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