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    Lnpep leucyl/cystinyl aminopeptidase [ Mus musculus (house mouse) ]

    Gene ID: 240028, updated on 9-Dec-2024

    Summary

    Official Symbol
    Lnpepprovided by MGI
    Official Full Name
    leucyl/cystinyl aminopeptidaseprovided by MGI
    Primary source
    MGI:MGI:2387123
    See related
    Ensembl:ENSMUSG00000023845 AllianceGenome:MGI:2387123
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CAP; IRAP; PLAP; gp160; vp165; 2010309L07Rik; 4732490P18Rik
    Summary
    Enables aminopeptidase activity. Involved in negative regulation of cold-induced thermogenesis. Acts upstream of or within protein catabolic process. Located in cytoplasmic vesicle membrane; perinuclear region of cytoplasm; and plasma membrane. Is expressed in extraembryonic component; labyrinthine zone; and placenta. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human LNPEP (leucyl and cystinyl aminopeptidase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in heart adult (RPKM 7.9), thymus adult (RPKM 6.0) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Lnpep in Genome Data Viewer
    Location:
    17 A3.2; 17 9.77 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (17747985..17846303, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (17527723..17624489, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_41952 Neighboring gene predicted gene, 26873 Neighboring gene limb and CNS expressed 1 Neighboring gene STARR-seq mESC enhancer starr_41957 Neighboring gene STARR-seq mESC enhancer starr_41959 Neighboring gene STARR-seq mESC enhancer starr_41960 Neighboring gene STARR-seq mESC enhancer starr_41961 Neighboring gene predicted gene, 41537 Neighboring gene proteasome (prosome, macropain) subunit, beta type 3 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E5575 Neighboring gene STARR-positive B cell enhancer ABC_E7491 Neighboring gene STARR-seq mESC enhancer starr_41962 Neighboring gene STARR-positive B cell enhancer ABC_E4194 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:17762259-17762524 Neighboring gene STARR-positive B cell enhancer ABC_E7492 Neighboring gene farnesyl diphosphate synthetase pseudogene Neighboring gene vomeronasal 2, receptor 90

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Gene trapped (1) 
    • Targeted (8)  1 citation

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables aminopeptidase activity PubMed 
    enables aminopeptidase activity  
    enables metalloaminopeptidase activity  
    enables metallopeptidase activity  
    enables peptide binding  
    enables protein binding PubMed 
    enables zinc ion binding  
    enables zinc ion binding  
    Process Evidence Code Pubs
    involved_in negative regulation of cold-induced thermogenesis PubMed 
    involved_in neuropeptide catabolic process  
    involved_in peptide catabolic process  
    involved_in peptide catabolic process  
    involved_in positive regulation of blood pressure  
    acts_upstream_of_or_within protein catabolic process PubMed 
    involved_in proteolysis  
    involved_in proteolysis  
    involved_in regulation of blood pressure  
    involved_in regulation of long-term neuronal synaptic plasticity  
    involved_in response to hormone  
    Component Evidence Code Pubs
    located_in cell surface  
    is_active_in cytoplasm  
    located_in cytoplasmic vesicle membrane PubMed 
    located_in cytoplasmic vesicle membrane  
    located_in endomembrane system  
    is_active_in extracellular space  
    located_in insulin-responsive compartment  
    located_in membrane PubMed 
    located_in neuronal cell body  
    located_in perinuclear region of cytoplasm PubMed 
    located_in perinuclear region of cytoplasm  
    is_active_in plasma membrane  
    located_in plasma membrane PubMed 
    located_in plasma membrane  
    located_in vesicle  

    General protein information

    Preferred Names
    leucyl-cystinyl aminopeptidase
    Names
    OTase
    cystinyl aminopeptidase
    oxytocinase
    NP_766415.1
    XP_036016480.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172827.3NP_766415.1  leucyl-cystinyl aminopeptidase

      See identical proteins and their annotated locations for NP_766415.1

      Status: PROVISIONAL

      Source sequence(s)
      AC121795, AC147983
      Consensus CDS
      CCDS37457.1
      UniProtKB/Swiss-Prot
      Q8C129
      Related
      ENSMUSP00000036998.3, ENSMUST00000041047.4
      Conserved Domains (2) summary
      cd09601
      Location:177612
      M1_APN-Q_like; Peptidase M1 aminopeptidase N catalytic domain family which includes aminopeptidase N (APN), aminopeptidase Q (APQ), tricorn interacting factor F3, and endoplasmic reticulum aminopeptidase 1 (ERAP1)
      pfam11838
      Location:6891009
      ERAP1_C; ERAP1-like C-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      17747985..17846303 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036160587.1XP_036016480.1  leucyl-cystinyl aminopeptidase isoform X1

      UniProtKB/TrEMBL
      Q6NY09
      Conserved Domains (1) summary
      cd09601
      Location:177595
      M1_APN-Q_like; Peptidase M1 aminopeptidase N catalytic domain family which includes aminopeptidase N (APN), aminopeptidase Q (APQ), tricorn interacting factor F3, and endoplasmic reticulum aminopeptidase 1 (ERAP1)
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