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    Serpind1 serine (or cysteine) peptidase inhibitor, clade D, member 1 [ Mus musculus (house mouse) ]

    Gene ID: 15160, updated on 9-Dec-2024

    Summary

    Official Symbol
    Serpind1provided by MGI
    Official Full Name
    serine (or cysteine) peptidase inhibitor, clade D, member 1provided by MGI
    Primary source
    MGI:MGI:96051
    See related
    Ensembl:ENSMUSG00000022766 AllianceGenome:MGI:96051
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    HCII; Hcf2; HC-II
    Summary
    Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in negative regulation of endopeptidase activity. Predicted to be active in extracellular space. Is expressed in liver. Human ortholog(s) of this gene implicated in heparin cofactor II deficiency. Orthologous to human SERPIND1 (serpin family D member 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in liver adult (RPKM 147.0), liver E18 (RPKM 126.4) and 3 other tissues See more
    Orthologs
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    Genomic context

    See Serpind1 in Genome Data Viewer
    Location:
    16 A3; 16 10.74 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (17149235..17161438)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (17331371..17343574)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E7430 Neighboring gene hypermethylated in cancer 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:17276268-17276485 Neighboring gene transmembrane protein 191 Neighboring gene phosphatidylinositol 4-kinase alpha Neighboring gene STARR-seq mESC enhancer starr_40252 Neighboring gene predicted gene, 24927 Neighboring gene poly(A) binding protein, cytoplasmic 1 pseudogene Neighboring gene synaptosomal-associated protein 29

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2)  1 citation

    Pathways from PubChem

    General gene information

    Clone Names

    • MGC107662

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables heparin binding  
    enables serine-type endopeptidase inhibitor activity  
    enables serine-type endopeptidase inhibitor activity  
    Process Evidence Code Pubs
    involved_in blood coagulation  
    involved_in negative regulation of endopeptidase activity  
    Component Evidence Code Pubs
    is_active_in extracellular space  
    located_in extracellular space  

    General protein information

    Preferred Names
    heparin cofactor 2
    Names
    heparin cofactor II
    protease inhibitor leuserpin-2
    serine (or cysteine) proteinase inhibitor, clade D (heparin cofactor), member 1
    serpin D1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001331047.1NP_001317976.1  heparin cofactor 2 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR comared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC110573, AI195091, BY770136, CJ238471
      Consensus CDS
      CCDS28000.1
      UniProtKB/Swiss-Prot
      P49182
      UniProtKB/TrEMBL
      Q5FW62
      Related
      ENSMUSP00000156303.2, ENSMUST00000231884.2
      Conserved Domains (1) summary
      cd02047
      Location:43476
      HCII; Heparin cofactor II (HCII) inhibits thrombin, the final protease of the coagulation cascade. HCII is allosterically activated by binding to cell surface glycosaminoglycans (GAGs). The specificity of HCII for thrombin is conferred by a highly acidic ...
    2. NM_008223.4NP_032249.3  heparin cofactor 2 precursor

      See identical proteins and their annotated locations for NP_032249.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AA253694, AC110573, AI195091, AI196697, AI529123, AI529613, CJ067925, CJ238471
      Consensus CDS
      CCDS28000.1
      UniProtKB/Swiss-Prot
      P49182
      UniProtKB/TrEMBL
      Q5FW62
      Related
      ENSMUSP00000023450.7, ENSMUST00000023450.15
      Conserved Domains (1) summary
      cd02047
      Location:43476
      HCII; Heparin cofactor II (HCII) inhibits thrombin, the final protease of the coagulation cascade. HCII is allosterically activated by binding to cell surface glycosaminoglycans (GAGs). The specificity of HCII for thrombin is conferred by a highly acidic ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      17149235..17161438
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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