U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 58801, updated on 27-Dec-2024

    Summary

    Official Symbol
    Pmaip1provided by MGI
    Official Full Name
    phorbol-12-myristate-13-acetate-induced protein 1provided by MGI
    Primary source
    MGI:MGI:1930146
    See related
    Ensembl:ENSMUSG00000024521 AllianceGenome:MGI:1930146
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Noxa
    Summary
    Involved in several processes, including apoptotic signaling pathway; negative regulation of mitochondrial membrane potential; and positive regulation of cysteine-type endopeptidase activity. Acts upstream of or within several processes, including intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; positive regulation of apoptotic process; and positive regulation of establishment of protein localization to mitochondrion. Located in mitochondrion. Is expressed in several structures, including brain; genitourinary system; immune system; limb; and liver. Orthologous to human PMAIP1 (phorbol-12-myristate-13-acetate-induced protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in placenta adult (RPKM 5.1), large intestine adult (RPKM 3.2) and 22 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Pmaip1 in Genome Data Viewer
    Location:
    18 E1; 18 39.52 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (66591675..66598629)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (66458604..66465558)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene collagen and calcium binding EGF domains 1 Neighboring gene predicted gene 15958 Neighboring gene STARR-seq mESC enhancer starr_44860 Neighboring gene STARR-positive B cell enhancer ABC_E7599 Neighboring gene STARR-seq mESC enhancer starr_44861 Neighboring gene STARR-seq mESC enhancer starr_44863 Neighboring gene STARR-positive B cell enhancer ABC_E8928 Neighboring gene STARR-positive B cell enhancer ABC_E7600 Neighboring gene predicted gene, 20294 Neighboring gene STARR-positive B cell enhancer ABC_E318 Neighboring gene STARR-positive B cell enhancer ABC_E7601 Neighboring gene STARR-seq mESC enhancer starr_44864 Neighboring gene STARR-positive B cell enhancer mm9_chr18:66678901-66679202 Neighboring gene STARR-positive B cell enhancer mm9_chr18:66679979-66680279 Neighboring gene predicted gene 9926 Neighboring gene predicted gene, 24679

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (4)  1 citation

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Items 1 - 25 of 35
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA damage response PubMed 
    involved_in T cell homeostasis PubMed 
    acts_upstream_of_or_within apoptotic process  
    involved_in cellular response to glucose starvation  
    involved_in defense response to virus  
    acts_upstream_of fibroblast apoptotic process PubMed 
    involved_in intrinsic apoptotic signaling pathway  
    involved_in intrinsic apoptotic signaling pathway by p53 class mediator PubMed 
    involved_in intrinsic apoptotic signaling pathway by p53 class mediator  
    acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to DNA damage PubMed 
    acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator PubMed 
    involved_in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress PubMed 
    acts_upstream_of_or_within negative regulation of fibroblast proliferation PubMed 
    involved_in negative regulation of mitochondrial membrane potential PubMed 
    involved_in positive regulation of DNA damage response, signal transduction by p53 class mediator PubMed 
    involved_in positive regulation of DNA damage response, signal transduction by p53 class mediator  
    involved_in positive regulation of apoptotic process  
    involved_in positive regulation of cysteine-type endopeptidase activity PubMed 
    involved_in positive regulation of cysteine-type endopeptidase activity  
    acts_upstream_of_or_within positive regulation of establishment of protein localization to mitochondrion PubMed 
    involved_in positive regulation of extrinsic apoptotic signaling pathway via death domain receptors  
    acts_upstream_of_or_within positive regulation of fibroblast apoptotic process PubMed 
    involved_in positive regulation of glucose metabolic process  
    involved_in positive regulation of intrinsic apoptotic signaling pathway  
    acts_upstream_of_or_within positive regulation of neuron apoptotic process PubMed 
    involved_in positive regulation of release of cytochrome c from mitochondria  
    involved_in proteasomal protein catabolic process  
    involved_in reactive oxygen species metabolic process  
    acts_upstream_of_or_within regulation of apoptotic process PubMed 
    involved_in regulation of mitochondrial membrane permeability  
    involved_in release of cytochrome c from mitochondria PubMed 
    acts_upstream_of_or_within release of cytochrome c from mitochondria PubMed 
    acts_upstream_of_or_within response to UV PubMed 
    acts_upstream_of_or_within response to X-ray PubMed 
    involved_in response to dsRNA  
    Items 1 - 25 of 35
    Component Evidence Code Pubs
    part_of Bcl-2 family protein complex  
    located_in cytosol  
    located_in mitochondrion PubMed 
    is_active_in mitochondrion  
    located_in mitochondrion PubMed 
    located_in mitochondrion  
    located_in nucleus  

    General protein information

    Preferred Names
    phorbol-12-myristate-13-acetate-induced protein 1
    Names
    protein Noxa

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021451.2NP_067426.1  phorbol-12-myristate-13-acetate-induced protein 1

      See identical proteins and their annotated locations for NP_067426.1

      Status: PROVISIONAL

      Source sequence(s)
      AC100212
      Consensus CDS
      CCDS29315.1
      UniProtKB/Swiss-Prot
      Q9JM54
      Related
      ENSMUSP00000025399.8, ENSMUST00000025399.9
      Conserved Domains (1) summary
      pfam15150
      Location:50103
      PMAIP1; Phorbol-12-myristate-13-acetate-induced

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      66591675..66598629
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    External link. Please review our privacy policy.