Arpc3 actin related protein 2/3 complex, subunit 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Arpc3provided by MGI
Official Full Name: actin related protein 2/3 complex, subunit 3provided by MGI
Primary source: MGI:MGI:1928375
See related: Ensembl:ENSMUSG00000029465 AllianceGenome:MGI:1928375
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: p21-Ar; p21Arc; p21-ARC; 1110006A04Rik
Summary: Predicted to be a structural constituent of cytoskeleton. Predicted to contribute to actin filament binding activity. Involved in regulation of synaptic vesicle endocytosis. Located in lamellipodium. Is expressed in lower jaw tooth and tooth. Orthologous to human ARPC3 (actin related protein 2/3 complex subunit 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in placenta adult (RPKM 128.4), large intestine adult (RPKM 106.1) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 F; 5 62.34 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (122529941..122544244)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (122391878..122406181)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Dysregulation of the Synaptic Cytoskeleton in the PFC Drives Neural Circuit Pathology, Leading to Social Dysfunction.
Title: Dysregulation of the Synaptic Cytoskeleton in the PFC Drives Neural Circuit Pathology, Leading to Social Dysfunction.
This study provided the first evidence that the Arp2/3 complex, a key actin nucleator, is involved in distinct stages of spine formation and is required for synapse unsilencing.
Title: The Arp2/3 Complex Is Essential for Distinct Stages of Spine Synapse Maturation, Including Synapse Unsilencing.
In the absence of ArpC3, enterocytes had defects in the organization of the endolysosomal system: transcytosis of IgG was disrupted, lipid absorption was perturbed, and neonatal mice died within days of birth.
Title: The Arp2/3 complex has essential roles in vesicle trafficking and transcytosis in the mammalian small intestine.
GMF debranches filaments by a mechanism related to cofilin-mediated severing, but in which GMF has evolved to target molecular junctions between actin-related proteins in the Arp2/3 complex and actin subunits in the daughter filament of the branch.
Title: GMF severs actin-Arp2/3 complex branch junctions by a cofilin-like mechanism.
Together with the observation that Gadkin-mediated inhibition of cell spreading requires its binding to ARP2/3, these data indicate that Gadkin is a negative regulator of ARP2/3 function present on intracellular membranes
Title: Gadkin negatively regulates cell spreading and motility via sequestration of the actin-nucleating ARP2/3 complex.
results demonstrate a critical role for the Arp2/3 complex in the assembly of lamellipodia-based leading edges and directional cell motility
Title: The Arp2/3 complex is required for lamellipodia extension and directional fibroblast cell migration.
that targeting of Arpc3 by miR-29a/b fine tunes structural plasticity by regulating actin network branching in mature and developing spines
Title: Targeting of the Arpc3 actin nucleation factor by miR-29a/b regulates dendritic spine morphology.
These data indicate the importance of Arpc3 in the Arp2/3 complex for trophoblast outgrowth and suggest that Arpc3 may be indispensable for implantation.
Title: Sleeping beauty transposon-based phenotypic analysis of mice: lack of Arpc3 results in defective trophoblast outgrowth.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Gene trapped (1)
Targeted (3) 1 citation
Transposon induced (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI788639 (e-PCR)
- UniSTS:179269

RH125811 (e-PCR)
- UniSTS:162557

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
contributes_to actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin filament binding	IEA Inferred from Electronic Annotation more info
contributes_to actin filament binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables structural constituent of cytoskeleton	IEA Inferred from Electronic Annotation more info
enables structural constituent of cytoskeleton	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in Arp2/3 complex-mediated actin nucleation	IBA Inferred from Biological aspect of Ancestor more info
involved_in Arp2/3 complex-mediated actin nucleation	IEA Inferred from Electronic Annotation more info
involved_in Arp2/3 complex-mediated actin nucleation	ISO Inferred from Sequence Orthology more info
involved_in regulation of actin filament polymerization	IEA Inferred from Electronic Annotation more info
involved_in regulation of synaptic vesicle endocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of synaptic vesicle endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of Arp2/3 protein complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Arp2/3 protein complex	ISO Inferred from Sequence Orthology more info
part_of Arp2/3 protein complex	ISS Inferred from Sequence or Structural Similarity more info
part_of Arp2/3 protein complex	TAS Traceable Author Statement more info	PubMed
located_in cell leading edge	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
part_of filamentous actin	ISO Inferred from Sequence Orthology more info
located_in growth cone leading edge	ISO Inferred from Sequence Orthology more info
located_in lamellipodium	IDA Inferred from Direct Assay more info	PubMed
located_in lamellipodium	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in site of double-strand break	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: actin-related protein 2/3 complex subunit 3

Names: Arp2/3 complex subunit p21-Arc; arp2/3 complex 21 kDa subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.