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    Mocs1 molybdenum cofactor synthesis 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 301221, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Mocs1provided by RGD
    Official Full Name
    molybdenum cofactor synthesis 1provided by RGD
    Primary source
    RGD:1308471
    See related
    EnsemblRapid:ENSRNOG00000011784 AllianceGenome:RGD:1308471
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including 4 iron, 4 sulfur cluster binding activity; GTP 3',8'-cyclase activity; and S-adenosyl-L-methionine binding activity. Predicted to be involved in Mo-molybdopterin cofactor biosynthetic process. Predicted to act upstream of or within molybdopterin cofactor biosynthetic process. Predicted to be located in cytosol and mitochondrion. Human ortholog(s) of this gene implicated in molybdenum cofactor deficiency type A. Orthologous to human MOCS1 (molybdenum cofactor synthesis 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Liver (RPKM 137.6), Kidney (RPKM 108.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mocs1 in Genome Data Viewer
    Location:
    9q12
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (19045223..19071628, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (11547533..11573935, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (13493705..13513972, complement)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene kinesin family member 6 Neighboring gene uncharacterized LOC134480334 Neighboring gene dishevelled associated activator of morphogenesis 2 Neighboring gene uncharacterized LOC134480336 Neighboring gene uncharacterized LOC120094630 Neighboring gene uncharacterized LOC108351887 Neighboring gene ribosomal protein L5, pseudogene 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Long-term rescue of a lethal inherited disease by adeno-associated virus-mediated gene transfer in a mouse model of molybdenum-cofactor deficiency. Kügler S, et al. Am J Hum Genet, 2007 Feb. PMID 17236133, Free PMC Article
    2. The pathogenesis of molybdenum cofactor deficiency, its delay by maternal clearance, and its expression pattern in microarray analysis. Reiss J, et al. Mol Genet Metab, 2005 May. PMID 15862276
    3. Characterization of MOCS1A, an oxygen-sensitive iron-sulfur protein involved in human molybdenum cofactor biosynthesis. Hänzelmann P, et al. J Biol Chem, 2004 Aug 13. PMID 15180982
    4. Molybdenum cofactor-deficient mice resemble the phenotype of human patients. Lee HJ, et al. Hum Mol Genet, 2002 Dec 15. PMID 12471057
    5. Genomic structure and mutational spectrum of the bicistronic MOCS1 gene defective in molybdenum cofactor deficiency type A. Reiss J, et al. Hum Genet, 1998 Dec. PMID 9921896

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 4 iron, 4 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 4 iron, 4 sulfur cluster binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables GTP 3',8'-cyclase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP 3',8'-cyclase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables S-adenosyl-L-methionine binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cyclic pyranopterin monophosphate synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cyclic pyranopterin monophosphate synthase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in Mo-molybdopterin cofactor biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in Mo-molybdopterin cofactor biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within molybdopterin cofactor biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in molybdopterin cofactor biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    molybdenum cofactor biosynthesis protein 1
    NP_001400697.1
    XP_008765063.1
    XP_038939095.1
    XP_038939096.1
    XP_038939097.1
    XP_038939099.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001413768.1 → NP_001400697.1  molybdenum cofactor biosynthesis protein 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A0A8I6GKB1, A6JIC9
      Related
      ENSRNOP00000092719.1, ENSRNOT00000105120.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      19045223..19071628 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039083167.2 → XP_038939095.1  molybdenum cofactor biosynthesis protein 1 isoform X1

      Conserved Domains (2) summary
      PLN02951
      Location:60 → 400
      PLN02951; Molybderin biosynthesis protein CNX2
      PRK09364
      Location:495 → 652
      moaC; cyclic pyranopterin monophosphate synthase MoaC

    2. XM_039083168.2 → XP_038939096.1  molybdenum cofactor biosynthesis protein 1 isoform X2

      Conserved Domains (2) summary
      PLN02951
      Location:1 → 185
      PLN02951; Molybderin biosynthesis protein CNX2
      PRK09364
      Location:280 → 437
      moaC; cyclic pyranopterin monophosphate synthase MoaC

    3. XM_039083171.2 → XP_038939099.1  molybdenum cofactor biosynthesis protein 1 isoform X5

      Conserved Domains (2) summary
      PLN02951
      Location:1 → 124
      PLN02951; Molybderin biosynthesis protein CNX2
      PRK09364
      Location:219 → 376
      moaC; cyclic pyranopterin monophosphate synthase MoaC

    4. XM_039083169.2 → XP_038939097.1  molybdenum cofactor biosynthesis protein 1 isoform X3

      Conserved Domains (1) summary
      PLN02951
      Location:60 → 401
      PLN02951; Molybderin biosynthesis protein CNX2

    5. XM_008766841.4 → XP_008765063.1  molybdenum cofactor biosynthesis protein 1 isoform X4

      UniProtKB/TrEMBL
      A6JIC8, D3ZVG1
      Conserved Domains (3) summary
      cd01335
      Location:74 → 272
      Radical_SAM; Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster. ...
      PLN02951
      Location:7 → 385
      PLN02951; Molybderin biosynthesis protein CNX2
      pfam06463
      Location:241 → 367
      Mob_synth_C; Molybdenum Cofactor Synthesis C
    Nucleotide Protein Strain
    Heading Accession and Version

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