Tbc1d2b TBC1 domain family, member 2B [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tbc1d2bprovided by RGD
Official Full Name: TBC1 domain family, member 2Bprovided by RGD
Primary source: RGD:1307436
See related: EnsemblRapid:ENSRNOG00000014543 AllianceGenome:RGD:1307436
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1307436
Summary: Predicted to enable GTPase activator activity. Predicted to be involved in endocytosis. Predicted to be located in cytosol and early endosome. Predicted to be active in cytoplasm and plasma membrane. Orthologous to human TBC1D2B (TBC1 domain family member 2B). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 223.9), Spleen (RPKM 124.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q31

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (99626019..99694669, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (90746220..90814867, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (97577551..97647072, complement)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

AI228491 (e-PCR)
- UniSTS:250502

RH131156 (e-PCR)
- UniSTS:214439

RH137479 (e-PCR)
- UniSTS:219567

BF387914 (e-PCR)
- UniSTS:244470

RH133286 (e-PCR)
- UniSTS:216569

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in endocytosis	ISO Inferred from Sequence Orthology more info
NOT involved_in regulation of cilium assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in early endosome	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: TBC1 domain family member 2B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001413794.1 → NP_001400723.1 TBC1 domain family member 2B

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

UniProtKB/TrEMBL

A0A8I6ALB6, A6I221, D3ZAF7

Related

ENSRNOP00000093906.1, ENSRNOT00000119718.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

99626019..99694669 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063265567.1 → XP_063121637.1 TBC1 domain family member 2B isoform X3

UniProtKB/TrEMBL

A6I221, D3ZAF7
XM_039081539.2 → XP_038937467.1 TBC1 domain family member 2B isoform X2

UniProtKB/TrEMBL

A6I221, D3ZAF7

Conserved Domains (2) summary

COG1196
Location:109 → 338

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam00566
Location:435 → 646

RabGAP-TBC; Rab-GTPase-TBC domain
XM_039081538.2 → XP_038937466.1 TBC1 domain family member 2B isoform X1

UniProtKB/TrEMBL

A6I221, D3ZAF7

Conserved Domains (3) summary

COG1196
Location:339 → 568

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd01265
Location:36 → 144

PH_TBC1D2A; TBC1 domain family member 2A pleckstrin homology (PH) domain

cl02495
Location:659 → 799

RabGAP-TBC; Rab-GTPase-TBC domain