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    RIOX1 ribosomal oxygenase 1 [ Homo sapiens (human) ]

    Gene ID: 79697, updated on 27-Nov-2024

    Summary

    Official Symbol
    RIOX1provided by HGNC
    Official Full Name
    ribosomal oxygenase 1provided by HGNC
    Primary source
    HGNC:HGNC:20968
    See related
    Ensembl:ENSG00000170468 MIM:611919; AllianceGenome:HGNC:20968
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ROX; NO66; JMJD9; MAPJD; URLC2; hsNO66; C14orf169
    Summary
    Enables peptidyl-histidine dioxygenase activity and protein demethylase activity. Predicted to be involved in negative regulation of DNA-templated transcription; negative regulation of osteoblast differentiation; and protein demethylation. Located in nucleolus. [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
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    Genomic context

    See RIOX1 in Genome Data Viewer
    Location:
    14q24.3
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (73490933..73493394)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (67698891..67701354)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (73957638..73960098)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:73743236-73743736 Neighboring gene NUMB endocytic adaptor protein Neighboring gene NANOG hESC enhancer GRCh37_chr14:73864401-73864904 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8697 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5908 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5909 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5910 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:73925581-73926114 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:73926115-73926648 Neighboring gene uncharacterized LOC101928143 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8698 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8699 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:73956718-73957623 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5911 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:73958602-73959102 Neighboring gene HEAT repeat containing 4 Neighboring gene acyl-CoA thioesterase 1 Neighboring gene uncharacterized LOC124903344 Neighboring gene 5',3'-nucleotidase, cytosolic pseudogene 2

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ21802

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 2-oxoglutarate-dependent dioxygenase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables 2-oxoglutarate-dependent dioxygenase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables histone H3K36 demethylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables histone H3K36 demethylase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables histone H3K36me/H3K36me2 demethylase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3K4 demethylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables histone H3K4me/H3K4me2/H3K4me3 demethylase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables iron ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables peptidyl-histidine dioxygenase activity EXP
    Inferred from Experiment
    more info
    PubMed 
    enables peptidyl-histidine dioxygenase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein demethylase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of osteoblast differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    ribosomal oxygenase 1
    Names
    60S ribosomal protein L8 histidine hydroxylase
    MYC-associated protein with JmjC domain
    bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66
    histone lysine demethylase NO66
    lysine-specific demethylase NO66
    nucleolar protein 66
    ribosomal oxygenase NO66
    up-regulated in lung cancer 2
    NP_078920.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_024644.5NP_078920.2  ribosomal oxygenase 1

      See identical proteins and their annotated locations for NP_078920.2

      Status: VALIDATED

      Source sequence(s)
      AC005280, BC071954, BX390965, CN259773, DA509240, DA872764, HY178771
      Consensus CDS
      CCDS73660.1
      UniProtKB/Swiss-Prot
      B4DT02, Q9H6W3
      UniProtKB/TrEMBL
      A0A0A8K8C0
      Related
      ENSP00000477507.1, ENST00000304061.8
      Conserved Domains (1) summary
      pfam08007
      Location:215557
      Cupin_4; Cupin superfamily protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      73490933..73493394
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      67698891..67701354
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)