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    Tfeb transcription factor EB [ Mus musculus (house mouse) ]

    Gene ID: 21425, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Tfebprovided by MGI
    Official Full Name
    transcription factor EBprovided by MGI
    Primary source
    MGI:MGI:103270
    See related
    Ensembl:ENSMUSG00000023990 AllianceGenome:MGI:103270
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tcfeb; bHLHe35
    Summary
    Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and protein heterodimerization activity. Involved in several processes, including defense response to Gram-negative bacterium; embryonic placenta development; and positive regulation of transcription by RNA polymerase II. Acts upstream of or within lysosome organization. Located in cytoplasm. Part of transcription regulator complex. Colocalizes with nucleus. Is expressed in several structures, including cardiovascular system; central nervous system; early conceptus; genitourinary system; and gut gland. Orthologous to human TFEB (transcription factor EB). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in spleen adult (RPKM 26.0), colon adult (RPKM 13.7) and 21 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tfeb in Genome Data Viewer
    Location:
    17 C; 17 23.99 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (48047962..48103341)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (47737037..47792416)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_42724 Neighboring gene predicted gene, 46579 Neighboring gene STARR-positive B cell enhancer ABC_E10960 Neighboring gene STARR-positive B cell enhancer ABC_E5617 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:47876786-47876895 Neighboring gene progastricsin (pepsinogen C) Neighboring gene STARR-positive B cell enhancer ABC_E2491 Neighboring gene STARR-positive B cell enhancer ABC_E5618 Neighboring gene STARR-seq mESC enhancer starr_42729 Neighboring gene MyoD family inhibitor Neighboring gene predicted gene, 25201

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. TFEB protein expression is reduced in aged brains and its overexpression mitigates senescence-associated biomarkers and memory deficits in mice. Wang H, et al. Neurobiol Aging, 2021 Oct. PMID 34229273
    2. TFEB regulates lysosomal exocytosis of tau and its loss of function exacerbates tau pathology and spreading. Xu Y, et al. Mol Psychiatry, 2021 Oct. PMID 32366951, Free PMC Article
    3. Loss of function of transcription factor EB remodels lipid metabolism and cell death pathways in the cardiomyocyte. Trivedi PC, et al. Biochim Biophys Acta Mol Basis Dis, 2020 Oct 1. PMID 32437957
    4. Activation of TFEB-mediated autophagy by trehalose attenuates mitochondrial dysfunction in cisplatin-induced acute kidney injury. Zhu L, et al. Theranostics, 2020. PMID 32483422, Free PMC Article
    5. Potentiation of rifampin activity in a mouse model of tuberculosis by activation of host transcription factor EB. Bryk R, et al. PLoS Pathog, 2020 Jun. PMID 32574211, Free PMC Article

    See all (234) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Estrogen Receptor-Related Orphan Receptors Regulate Autophagy through TFEB.
      Title: The Estrogen Receptor-Related Orphan Receptors Regulate Autophagy through TFEB.
    2. Lysosomal Ca[2+] release-facilitated TFEB nuclear translocation alleviates ischemic brain injury by attenuating autophagic/lysosomal dysfunction in neurons.
      Title: Lysosomal Ca(2+) release-facilitated TFEB nuclear translocation alleviates ischemic brain injury by attenuating autophagic/lysosomal dysfunction in neurons.
    3. TFEB activation hallmarks antigenic experience of B lymphocytes and directs germinal center fate decisions.
      Title: TFEB activation hallmarks antigenic experience of B lymphocytes and directs germinal center fate decisions.
    4. TFEB alleviates periodontitis by activating autophagy and inhibiting inflammation.
      Title: TFEB alleviates periodontitis by activating autophagy and inhibiting inflammation.
    5. TFEB safeguards trophoblast syncytialization in humans and mice.
      Title: TFEB safeguards trophoblast syncytialization in humans and mice.
    6. A potential early-atheroprotective target: Irgm1 mediates lymphangiogenesis through LEC autophagy by Tfeb translocation.
      Title: A potential early-atheroprotective target: Irgm1 mediates lymphangiogenesis through LEC autophagy by Tfeb translocation.
    7. Muscle-bone cross-talk through the FNIP1-TFEB-IGF2 axis is associated with bone metabolism in human and mouse.
      Title: Muscle-bone cross-talk through the FNIP1-TFEB-IGF2 axis is associated with bone metabolism in human and mouse.
    8. Transcription factor EB modulates the homeostasis of reactive oxygen species in intestinal epithelial cells to alleviate inflammatory bowel disease.
      Title: Transcription factor EB modulates the homeostasis of reactive oxygen species in intestinal epithelial cells to alleviate inflammatory bowel disease.
    9. TFEB regulates dendritic cell antigen presentation to modulate immune balance in asthma.
      Title: TFEB regulates dendritic cell antigen presentation to modulate immune balance in asthma.
    10. Erbin accelerates TFEB-mediated lysosome biogenesis and autophagy and alleviates sepsis-induced inflammatory responses and organ injuries.
      Title: Erbin accelerates TFEB-mediated lysosome biogenesis and autophagy and alleviates sepsis-induced inflammatory responses and organ injuries.
    Submit: New GeneRIF Correction See all GeneRIFs (127)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein heterodimerization activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription cis-regulatory region binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transcription cis-regulatory region binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in adaptive immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in antibacterial innate immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in antibacterial innate immune response ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in autophagy IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to amino acid starvation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to amino acid starvation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cellular response to starvation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to starvation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in defense response to Gram-negative bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in embryonic placenta development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in humoral immune response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lysosome localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within lysosome organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lysosome organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lysosome organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of autophagy ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of autophagy ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in lysosomal membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lysosomal membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    colocalizes_with nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of transcription regulator complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    transcription factor EB

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001161722.2 → NP_001155194.1  transcription factor EB

      See identical proteins and their annotated locations for NP_001155194.1

      Status: VALIDATED

      Source sequence(s)
      AC113536, AC124830
      Consensus CDS
      CCDS50133.1
      UniProtKB/Swiss-Prot
      Q9R210
      UniProtKB/TrEMBL
      Q3U327
      Related
      ENSMUSP00000084151.4, ENSMUST00000086932.10
      Conserved Domains (3) summary
      pfam11851
      Location:320 → 472
      DUF3371; Domain of unknown function (DUF3371)
      pfam15951
      Location:4 → 161
      MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus
      cd18927
      Location:225 → 315
      bHLHzip_TFEB; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor EB (TFEB) and similar proteins

    2. NM_001161723.2 → NP_001155195.1  transcription factor EB

      See identical proteins and their annotated locations for NP_001155195.1

      Status: VALIDATED

      Source sequence(s)
      AC113536, AC124830
      Consensus CDS
      CCDS50133.1
      UniProtKB/Swiss-Prot
      Q9R210
      UniProtKB/TrEMBL
      Q3U327
      Related
      ENSMUSP00000108913.2, ENSMUST00000113288.8
      Conserved Domains (3) summary
      pfam11851
      Location:320 → 472
      DUF3371; Domain of unknown function (DUF3371)
      pfam15951
      Location:4 → 161
      MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus
      cd18927
      Location:225 → 315
      bHLHzip_TFEB; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor EB (TFEB) and similar proteins

    3. NM_001432178.1 → NP_001419107.1  transcription factor EB

      Status: VALIDATED

      Source sequence(s)
      AC113536, AC124830
      UniProtKB/Swiss-Prot
      Q9R210
      UniProtKB/TrEMBL
      Q3U327

    4. NM_001432179.1 → NP_001419108.1  transcription factor EB

      Status: VALIDATED

      Source sequence(s)
      AC113536, AC124830
      UniProtKB/Swiss-Prot
      Q9R210
      UniProtKB/TrEMBL
      Q3U327

    5. NM_001432180.1 → NP_001419109.1  transcription factor EB

      Status: VALIDATED

      Source sequence(s)
      AC113536, AC124830
      UniProtKB/Swiss-Prot
      Q9R210
      UniProtKB/TrEMBL
      Q3U327

    6. NM_001432181.1 → NP_001419110.1  transcription factor EB

      Status: VALIDATED

      Source sequence(s)
      AC113536, AC124830
      UniProtKB/Swiss-Prot
      Q9R210
      UniProtKB/TrEMBL
      Q3U327

    7. NM_011549.4 → NP_035679.4  transcription factor EB

      Status: VALIDATED

      Source sequence(s)
      AC113536
      Consensus CDS
      CCDS28856.1
      UniProtKB/Swiss-Prot
      Q9R210
      UniProtKB/TrEMBL
      Q3U327
      Related
      ENSMUSP00000024786.8, ENSMUST00000024786.14

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      48047962..48103341
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006524007.5 → XP_006524070.1  transcription factor EB isoform X1

      Conserved Domains (3) summary
      pfam11851
      Location:320 → 472
      DUF3371; Domain of unknown function (DUF3371)
      pfam15951
      Location:4 → 161
      MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus
      cd18927
      Location:225 → 315
      bHLHzip_TFEB; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor EB (TFEB) and similar proteins

    2. XM_006524006.4 → XP_006524069.1  transcription factor EB isoform X1

      Conserved Domains (3) summary
      pfam11851
      Location:320 → 472
      DUF3371; Domain of unknown function (DUF3371)
      pfam15951
      Location:4 → 161
      MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus
      cd18927
      Location:225 → 315
      bHLHzip_TFEB; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor EB (TFEB) and similar proteins

    3. XM_006524004.1 → XP_006524067.1  transcription factor EB isoform X2

      UniProtKB/TrEMBL
      Q3U327
      Conserved Domains (3) summary
      pfam11851
      Location:355 → 507
      DUF3371; Domain of unknown function (DUF3371)
      pfam15951
      Location:39 → 196
      MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus
      cd18927
      Location:260 → 350
      bHLHzip_TFEB; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor EB (TFEB) and similar proteins

    4. XM_006524003.4 → XP_006524066.2  transcription factor EB isoform X1

      See identical proteins and their annotated locations for XP_006524066.2

      UniProtKB/Swiss-Prot
      Q9R210
      UniProtKB/TrEMBL
      Q3U327
      Conserved Domains (3) summary
      pfam11851
      Location:320 → 472
      DUF3371; Domain of unknown function (DUF3371)
      pfam15951
      Location:4 → 161
      MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus
      cd18927
      Location:225 → 315
      bHLHzip_TFEB; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor EB (TFEB) and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9R210.2 GenPept UniProtKB/Swiss-Prot:Q9R210

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