Tifa TRAF-interacting protein with forkhead-associated domain [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tifaprovided by MGI
Official Full Name: TRAF-interacting protein with forkhead-associated domainprovided by MGI
Primary source: MGI:MGI:2182965
See related: Ensembl:ENSMUSG00000046688 AllianceGenome:MGI:2182965
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: T2bp
Summary: Involved in positive regulation of canonical NF-kappaB signal transduction and tumor necrosis factor-mediated signaling pathway. Predicted to be active in cytoplasm. Is expressed in several structures, including brain ventricular layer; cerebral cortex subventricular zone; gut; liver; and trigeminal ganglion. Orthologous to human TIFA (TRAF interacting protein with forkhead associated domain). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in large intestine adult (RPKM 20.9), colon adult (RPKM 4.1) and 12 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 G2; 3 56.54 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (127582524..127592043)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (127788875..127798394)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TIFA contributes to periodontitis in diabetic mice via activating the NF-kappaB signaling pathway.
Title: TIFA contributes to periodontitis in diabetic mice via activating the NF‑κB signaling pathway.
The potential biomarker TIFA regulates pyroptosis in sepsis-induced acute kidney injury.
Title: The potential biomarker TIFA regulates pyroptosis in sepsis-induced acute kidney injury.
The increase in TIFA level appears to be a feed-forward mechanism involved in TLR4/MyD88-dependent signaling, leading to NF-kappaB activation and HMGB1 release
Title: TIFA upregulation after hypoxia-reoxygenation is TLR4- and MyD88-dependent and associated with HMGB1 upregulation and release.
We propose that ZCCHC11 is a unique TLR signal regulator, which interacts with TIFA after LPS treatment and suppresses the TRAF6-dependent activation of NF-kappaB.
Title: A novel Zinc finger protein, ZCCHC11, interacts with TIFA and modulates TLR signaling.
TIFA is likely to mediate IRAK-1/TRAF6 interaction upon IL-1 stimulation
Title: Identification of TIFA as an adapter protein that links tumor necrosis factor receptor-associated factor 6 (TRAF6) to interleukin-1 (IL-1) receptor-associated kinase-1 (IRAK-1) in IL-1 receptor signaling.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cytoplasmic pattern recognition receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cytoplasmic pattern recognition receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cytoplasmic pattern recognition receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in innate immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in innate immune response	ISO Inferred from Sequence Orthology more info
involved_in innate immune response	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of canonical NF-kappaB signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of canonical NF-kappaB signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical NF-kappaB signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein homooligomerization	ISO Inferred from Sequence Orthology more info
involved_in protein homooligomerization	ISS Inferred from Sequence or Structural Similarity more info
involved_in tumor necrosis factor-mediated signaling pathway	IPI Inferred from Physical Interaction more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: TRAF-interacting protein with FHA domain-containing protein A

Names: Traf2 binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001356430.1 → NP_001343359.1 TRAF-interacting protein with FHA domain-containing protein A

Status: VALIDATED

Source sequence(s)

AC163391, AK041891, AK149408

Consensus CDS

CCDS38628.1

UniProtKB/Swiss-Prot

Q3TLY9, Q793I8

UniProtKB/TrEMBL

I3PQW8

Related

ENSMUSP00000126692.2, ENSMUST00000164447.3

Conserved Domains (1) summary

cd00060
Location:46 → 128

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
NM_145133.4 → NP_660115.1 TRAF-interacting protein with FHA domain-containing protein A

See identical proteins and their annotated locations for NP_660115.1

Status: VALIDATED

Source sequence(s)

AB062111, AC163391, BY168652

Consensus CDS

CCDS38628.1

UniProtKB/Swiss-Prot

Q3TLY9, Q793I8

UniProtKB/TrEMBL

I3PQW8

Related

ENSMUSP00000054036.8, ENSMUST00000054483.14

Conserved Domains (1) summary

cd00060
Location:46 → 128

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000069.7 Reference GRCm39 C57BL/6J

Range

127582524..127592043

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036162993.1 → XP_036018886.1 TRAF-interacting protein with FHA domain-containing protein A isoform X1

Conserved Domains (1) summary

cd00060
Location:174 → 256

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
XM_006501237.4 → XP_006501300.1 TRAF-interacting protein with FHA domain-containing protein A isoform X2

See identical proteins and their annotated locations for XP_006501300.1

UniProtKB/Swiss-Prot

Q3TLY9, Q793I8

UniProtKB/TrEMBL

I3PQW8

Conserved Domains (1) summary

cd00060
Location:46 → 128

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
XM_006501238.5 → XP_006501301.1 TRAF-interacting protein with FHA domain-containing protein A isoform X2

See identical proteins and their annotated locations for XP_006501301.1

UniProtKB/Swiss-Prot

Q3TLY9, Q793I8

UniProtKB/TrEMBL

I3PQW8

Conserved Domains (1) summary

cd00060
Location:46 → 128

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...