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    Orm2 orosomucoid 2 [ Mus musculus (house mouse) ]

    Gene ID: 18406, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Orm2provided by MGI
    Official Full Name
    orosomucoid 2provided by MGI
    Primary source
    MGI:MGI:97444
    See related
    Ensembl:ENSMUSG00000061540 AllianceGenome:MGI:97444
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Agp1; Orm-2
    Summary
    Predicted to enable small molecule binding activity. Predicted to be involved in acute-phase response and regulation of immune system process. Predicted to be active in extracellular space. Orthologous to several human genes including ORM2 (orosomucoid 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in liver adult (RPKM 37.5), subcutaneous fat pad adult (RPKM 8.0) and 2 other tissues See more
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    Genomic context

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    See Orm2 in Genome Data Viewer
    Location:
    4 B3; 4 33.96 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (63280543..63284114)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (63362449..63365877)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene orosomucoid 1 pseudogene Neighboring gene orosomucoid 3 Neighboring gene AT-hook transcription factor Neighboring gene AT-hook transcription factor, opposite strand Neighboring gene predicted gene, 52742

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Orm2 Deficiency Aggravates High-Fat Diet-Induced Obesity through Gut Microbial Dysbiosis and Intestinal Inflammation. Li L, et al. Mol Nutr Food Res, 2024 Jan. PMID 37853937
    2. Mitigation of non-alcoholic steatohepatitis via recombinant Orosomucoid 2, an acute phase protein modulating the Erk1/2-PPARγ-Cd36 pathway. Li L, et al. Cell Rep, 2023 Jul 25. PMID 37355990
    3. Contribution of the α(1)-Acid Glycoprotein in Drug Pharmacokinetics: The Usefulness of α(1)-Acid Glycoprotein-Knockout Mice. Nakamura Y, et al. Mol Pharm, 2024 Jul 1. PMID 38862418
    4. An acute phase protein α(1)-acid glycoprotein mitigates AKI and its progression to CKD through its anti-inflammatory action. Watanabe H, et al. Sci Rep, 2021 Apr 12. PMID 33846468, Free PMC Article
    5. A synthetic retinoic acid receptor agonist Am80 ameliorates renal fibrosis via inducing the production of alpha-1-acid glycoprotein. Watanabe H, et al. Sci Rep, 2020 Jul 10. PMID 32651445, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Orm2 Deficiency Aggravates High-Fat Diet-Induced Obesity through Gut Microbial Dysbiosis and Intestinal Inflammation.
      Title: Orm2 Deficiency Aggravates High-Fat Diet-Induced Obesity through Gut Microbial Dysbiosis and Intestinal Inflammation.
    2. Mitigation of non-alcoholic steatohepatitis via recombinant Orosomucoid 2, an acute phase protein modulating the Erk1/2-PPARgamma-Cd36 pathway.
      Title: Mitigation of non-alcoholic steatohepatitis via recombinant Orosomucoid 2, an acute phase protein modulating the Erk1/2-PPARγ-Cd36 pathway.
    3. Orosomucoid 2 maintains hepatic lipid homeostasis through suppression of de novo lipogenesis.
      Title: Orosomucoid 2 maintains hepatic lipid homeostasis through suppression of de novo lipogenesis.
    4. The bile acid induced hepatokine orosomucoid suppresses adipocyte differentiation.
      Title: The bile acid induced hepatokine orosomucoid suppresses adipocyte differentiation.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4)  1 citation
    • Targeted (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables small molecule binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in acute-phase response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of immune system process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    alpha-1-acid glycoprotein 2
    Names
    AGP 2
    OMD 2
    bM340H1.5 (orosomucoid 2)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011016.2 → NP_035146.1  alpha-1-acid glycoprotein 2 precursor

      See identical proteins and their annotated locations for NP_035146.1

      Status: VALIDATED

      Source sequence(s)
      CB949119, M27009
      Consensus CDS
      CCDS18253.1
      UniProtKB/Swiss-Prot
      P07361
      Related
      ENSMUSP00000074810.4, ENSMUST00000075341.4
      Conserved Domains (1) summary
      pfam00061
      Location:43 → 181
      Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      63280543..63284114
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036163821.1 → XP_036019714.1  alpha-1-acid glycoprotein 2 isoform X1

      Conserved Domains (1) summary
      cl10502
      Location:21 → 145
      lipocalin_FABP; lipocalin/cytosolic fatty acid-binding protein family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P07361.1 GenPept UniProtKB/Swiss-Prot:P07361

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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