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    Myo19 myosin XIX [ Mus musculus (house mouse) ]

    Gene ID: 66196, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Myo19provided by MGI
    Official Full Name
    myosin XIXprovided by MGI
    Primary source
    MGI:MGI:1913446
    See related
    Ensembl:ENSMUSG00000020527 AllianceGenome:MGI:1913446
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Myohd1; 1110055A02Rik
    Summary
    Enables ATP hydrolysis activity; myosin light chain binding activity; and plus-end directed microfilament motor activity. Acts upstream of or within mitocytosis. Predicted to be located in cytosol and mitochondrial outer membrane. Predicted to be part of myosin complex. Predicted to be active in several cellular components, including actin cytoskeleton; cytoplasm; and vesicle. Is expressed in several structures, including adenohypophysis; alimentary system; skeleton; submandibular gland primordium; and vomeronasal organ. Orthologous to human MYO19 (myosin XIX). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in colon adult (RPKM 17.9), kidney adult (RPKM 12.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Myo19 in Genome Data Viewer
    Location:
    11 C; 11 51.34 cM
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (84770996..84802052)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (84880170..84911226)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930502E09 gene Neighboring gene STARR-positive B cell enhancer ABC_E3986 Neighboring gene gametogenetin binding protein 2 Neighboring gene STARR-seq mESC enhancer starr_30226 Neighboring gene STARR-seq mESC enhancer starr_30227 Neighboring gene STARR-positive B cell enhancer ABC_E7033 Neighboring gene gametogenetin binding protein 2, opposite strand Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class W Neighboring gene zinc finger, HIT type 3 Neighboring gene predicted gene, 33028 Neighboring gene predicted gene, 32917 Neighboring gene carbonic anhydrase 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mouse myosin-19 is a plus-end-directed, high-duty ratio molecular motor. Lu Z, et al. J Biol Chem, 2014 Jun 27. PMID 24825904, Free PMC Article
    2. Mitocytosis, a migrasome-mediated mitochondrial quality-control process. Jiao H, et al. Cell, 2021 May 27. PMID 34048705
    3. A Comprehensive Analysis of Fibroblast Growth Factor Receptor 2b Signaling on Epithelial Tip Progenitor Cells During Early Mouse Lung Branching Morphogenesis. Jones MR, et al. Front Genet, 2018. PMID 30728831, Free PMC Article
    4. The central role of EED in the orchestration of polycomb group complexes. Cao Q, et al. Nat Commun, 2014. PMID 24457600, Free PMC Article
    5. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Myo19 is a high-duty ratio molecular motor moving to the plus-end of the actin filament.
      Title: Mouse myosin-19 is a plus-end-directed, high-duty ratio molecular motor.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ATP hydrolysis activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables actin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables actin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microfilament motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables myosin light chain binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables plus-end directed microfilament motor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within mitochondrion migration along actin filament ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within mitocytosis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within mitocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cytokinesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cytokinesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of mitochondrial fission ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of mitochondrial fission ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial outer membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial outer membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of myosin complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    unconventional myosin-XIX
    Names
    myosin head domain containing 1
    myosin head domain-containing protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001362893.1 → NP_001349822.1  unconventional myosin-XIX isoform 2

      Status: VALIDATED

      Source sequence(s)
      AK080117, AL645623
      Related
      ENSMUST00000124152.8
      Conserved Domains (2) summary
      pfam00612
      Location:511 → 531
      IQ; IQ calmodulin-binding motif
      cl22853
      Location:18 → 473
      Motor_domain; Myosin and Kinesin motor domain

    2. NM_025414.4 → NP_079690.2  unconventional myosin-XIX isoform 1

      See identical proteins and their annotated locations for NP_079690.2

      Status: VALIDATED

      Source sequence(s)
      AK018609, AK080117, AL645623, BC060115, BU613548, CA749671
      Consensus CDS
      CCDS48871.1
      UniProtKB/Swiss-Prot
      Q5SV80, Q8BH54, Q9D2Z3
      Related
      ENSMUSP00000091502.5, ENSMUST00000093969.11
      Conserved Domains (2) summary
      cd14880
      Location:49 → 746
      MYSc_Myo19; class XIX myosin, motor domain
      pfam00612
      Location:784 → 804
      IQ; IQ calmodulin-binding motif

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      84770996..84802052
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011249173.3 → XP_011247475.1  unconventional myosin-XIX isoform X1

      See identical proteins and their annotated locations for XP_011247475.1

      UniProtKB/Swiss-Prot
      Q5SV80, Q8BH54, Q9D2Z3
      Conserved Domains (2) summary
      cd14880
      Location:49 → 746
      MYSc_Myo19; class XIX myosin, motor domain
      pfam00612
      Location:784 → 804
      IQ; IQ calmodulin-binding motif

    2. XM_036156894.1 → XP_036012787.1  unconventional myosin-XIX isoform X5

      Related
      ENSMUST00000141173.2
      Conserved Domains (2) summary
      pfam00612
      Location:511 → 531
      IQ; IQ calmodulin-binding motif
      cl22853
      Location:18 → 473
      Motor_domain; Myosin and Kinesin motor domain

    3. XM_011249174.3 → XP_011247476.1  unconventional myosin-XIX isoform X2

      Conserved Domains (2) summary
      cl22853
      Location:49 → 688
      Motor_domain; Myosin and Kinesin motor domain
      pfam00612
      Location:726 → 746
      IQ; IQ calmodulin-binding motif

    4. XM_030246221.1 → XP_030102081.1  unconventional myosin-XIX isoform X4

      Conserved Domains (2) summary
      pfam00612
      Location:575 → 595
      IQ; IQ calmodulin-binding motif
      cl22853
      Location:1 → 537
      Motor_domain; Myosin and Kinesin motor domain

    5. XM_036156892.1 → XP_036012785.1  unconventional myosin-XIX isoform X3

      Conserved Domains (2) summary
      pfam00612
      Location:639 → 659
      IQ; IQ calmodulin-binding motif
      cl22853
      Location:1 → 601
      Motor_domain; Myosin and Kinesin motor domain

    6. XM_036156893.1 → XP_036012786.1  unconventional myosin-XIX isoform X4

      Conserved Domains (2) summary
      pfam00612
      Location:575 → 595
      IQ; IQ calmodulin-binding motif
      cl22853
      Location:1 → 537
      Motor_domain; Myosin and Kinesin motor domain

    7. XM_036156895.1 → XP_036012788.1  unconventional myosin-XIX isoform X5

      Conserved Domains (2) summary
      pfam00612
      Location:511 → 531
      IQ; IQ calmodulin-binding motif
      cl22853
      Location:18 → 473
      Motor_domain; Myosin and Kinesin motor domain

    8. XM_006533930.4 → XP_006533993.1  unconventional myosin-XIX isoform X6

      Conserved Domains (2) summary
      cl22853
      Location:1 → 403
      Motor_domain; Myosin and Kinesin motor domain
      pfam00612
      Location:441 → 461
      IQ; IQ calmodulin-binding motif

    RNA

    1. XR_003949489.1 RNA Sequence

    2. XR_004937003.1 RNA Sequence

    3. XR_879727.4 RNA Sequence

    4. XR_004937004.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5SV80.1 GenPept UniProtKB/Swiss-Prot:Q5SV80

    Gene LinkOut

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