Snurf SNRPN upstream reading frame [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Snurfprovided by MGI
Official Full Name: SNRPN upstream reading frameprovided by MGI
Primary source: MGI:MGI:1891236
See related: Ensembl:ENSMUSG00000102627 AllianceGenome:MGI:1891236
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 2410045I01Rik
Summary: This gene is located within the mouse orthologous Prader-Willi Syndrome critical region and is imprinted and expressed from the paternal allele. This transcipt is thought to be bicistronic and can encode the small nuclear ribonucleoprotein polypeptide N (Snrpn) from a downstream open reading frame. The small protein represented by this gene is encoded by an evolutionarily-conserved upstream open reading frame and is localized to the nucleus. [provided by RefSeq, Mar 2017]
Expression: Biased expression in cerebellum adult (RPKM 239.9), cortex adult (RPKM 239.6) and 8 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 B5; 7 34.04 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (59632243..59654947, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (59982495..60005199, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the ATG-to-AAG mutation causes a 15-fold or more increase in translation of the downstream ORF in two fusion constructs, and it is likely that similar translational control affects the normal Snurf-Snrpn transcript as well
Title: Evidence for translational regulation of the imprinted Snurf-Snrpn locus in mice.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

General gene information

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Markers

BB264453 (e-PCR)
- UniSTS:208137

Snrpn (e-PCR), detects polymorphism
- UniSTS:144468

Snrpn (e-PCR), detects polymorphism
- UniSTS:144469

Snrpn (e-PCR), detects polymorphism
- UniSTS:144470

Snrpn (e-PCR), detects polymorphism
- UniSTS:144471

Snrpn (e-PCR), detects polymorphism
- UniSTS:144472

Snrpn-ps1 (e-PCR), detects polymorphism
- UniSTS:144473

Snrpn-ps1 (e-PCR), detects polymorphism
- UniSTS:144474

Snrpn (e-PCR), detects polymorphism
- UniSTS:547470

PMC87265P3 (e-PCR)
- UniSTS:273591

PMC21909P1 (e-PCR)
- UniSTS:272077

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATPase binding	IPI Inferred from Physical Interaction more info

Component	Evidence Code	Pubs
is_active_in nuclear speck	IBA Inferred from Biological aspect of Ancestor more info
located_in nuclear speck	IEA Inferred from Electronic Annotation more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: SNRPN upstream reading frame protein

Names: small nuclear ribonucleoprotein N

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.