Grxcr2 glutaredoxin, cysteine rich 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Grxcr2provided by MGI
Official Full Name: glutaredoxin, cysteine rich 2provided by MGI
Primary source: MGI:MGI:2685697
See related: Ensembl:ENSMUSG00000073574 AllianceGenome:MGI:2685697
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gm851
Summary: Acts upstream of or within auditory receptor cell stereocilium organization; protein localization to organelle; and sensory perception of sound. Located in microvillus; stereocilium base; and stereocilium shaft. Is expressed in cochlea epithelium and utricle epithelium. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 101. Orthologous to human GRXCR2 (glutaredoxin and cysteine rich domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 18 B3; 18 22.14 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	18	NC_000084.7 (42118388..42132114, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	18	NC_000084.6 (41985323..41999049, complement)

Chromosome 18 - NC_000084.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Stereocilia lacking GRXCR2 are longer than normal and disorganized due to the mislocalization of taperin, which could modulate the actin cytoskeleton in stereocilia.
Title: GRXCR2 Regulates Taperin Localization Critical for Stereocilia Morphology and Hearing.
GRXCR2 plays an intrinsic role in bundle orientation, organization, and sensory function in the inner ear during development and at maturity
Title: Grxcr2 is required for stereocilia morphogenesis in the cochlea.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5) 1 citation
Targeted (3) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within auditory receptor cell stereocilium organization	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within auditory receptor cell stereocilium organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within inner ear receptor cell stereocilium organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein localization to organelle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sensory perception of sound	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within sensory perception of sound	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within sensory perception of sound	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytosol	TAS Traceable Author Statement more info
is_active_in microvillus	IBA Inferred from Biological aspect of Ancestor more info
located_in microvillus	IDA Inferred from Direct Assay more info	PubMed
located_in microvillus	ISO Inferred from Sequence Orthology more info
is_active_in stereocilium base	IBA Inferred from Biological aspect of Ancestor more info
located_in stereocilium base	IDA Inferred from Direct Assay more info	PubMed
is_active_in stereocilium shaft	IBA Inferred from Biological aspect of Ancestor more info
located_in stereocilium shaft	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: glutaredoxin domain-containing cysteine-rich protein 2

Names: GRXCR1-like protein; glutaredoxin domain-containing cysteine-rich protein 1-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.