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    Poglut2 protein O-glucosyltransferase 2 [ Mus musculus (house mouse) ]

    Gene ID: 72050, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Poglut2provided by MGI
    Official Full Name
    protein O-glucosyltransferase 2provided by MGI
    Primary source
    MGI:MGI:1919300
    See related
    Ensembl:ENSMUSG00000026047 AllianceGenome:MGI:1919300
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    EP58; Kdel1; Kdelc1; 1810049A15Rik; 5730416C13Rik
    Summary
    Predicted to enable UDP-glucosyltransferase activity and UDP-xylosyltransferase activity. Predicted to be involved in protein O-linked glycosylation via serine. Located in endoplasmic reticulum lumen. Is expressed in several structures, including brain; genitourinary system; gut; liver; and spleen. Orthologous to human POGLUT2 (protein O-glucosyltransferase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 19.9), ovary adult (RPKM 16.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Poglut2 in Genome Data Viewer
    Location:
    1 C1.1; 1 23.54 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (44143060..44158844, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (44106546..44118880, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 168 Neighboring gene testis expressed 30 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:44176158-44176267 Neighboring gene basic, immunoglobulin-like variable motif containing Neighboring gene STARR-positive B cell enhancer mm9_chr1:44204561-44204862 Neighboring gene excision repair cross-complementing rodent repair deficiency, complementation group 5 Neighboring gene methyltransferase like 21E Neighboring gene predicted gene 15833

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of a novel mammalian endoplasmic reticulum-resident KDEL protein using an EST database motif search. Kimata Y, et al. Gene, 2000 Dec 31. PMID 11167020
    2. Rumi functions as both a protein O-glucosyltransferase and a protein O-xylosyltransferase. Takeuchi H, et al. Proc Natl Acad Sci U S A, 2011 Oct 4. PMID 21949356, Free PMC Article
    3. Regulation of mammalian Notch signaling and embryonic development by the protein O-glucosyltransferase Rumi. Fernandez-Valdivia R, et al. Development, 2011 May. PMID 21490058, Free PMC Article
    4. Poglut2/3 double knockout in mice results in neonatal lethality with reduced levels of fibrillin in lung tissues. Neupane S, et al. J Biol Chem, 2024 Jul. PMID 38844137, Free PMC Article
    5. A global genomic transcriptional code associated with CNS-expressed genes. Bailey PJ, et al. Exp Cell Res, 2006 Oct 1. PMID 16919269

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Poglut2/3 double knockout in mice results in neonatal lethality with reduced levels of fibrillin in lung tissues.
      Title: Poglut2/3 double knockout in mice results in neonatal lethality with reduced levels of fibrillin in lung tissues.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (4) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables EGF-domain serine glucosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables EGF-domain serine xylosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables UDP-glucosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables UDP-glucosyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables UDP-xylosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables UDP-xylosyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables glucosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein O-linked glycosylation via serine ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein O-linked glycosylation via serine ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum lumen IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein O-glucosyltransferase 2
    Names
    ER protein 58
    ERp58
    KDEL (Lys-Asp-Glu-Leu) containing 1
    KDEL containing protein 1
    KDEL motif-containing protein 1
    endoplasmic reticulum resident protein 58
    endoplasmic reticulum-resident KDEL protein
    protein O-xylosyltransferase POGLUT2
    NP_076134.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_023645.3 → NP_076134.1  protein O-glucosyltransferase 2 precursor

      See identical proteins and their annotated locations for NP_076134.1

      Status: PROVISIONAL

      Source sequence(s)
      AK035899
      Consensus CDS
      CCDS14929.1
      UniProtKB/Swiss-Prot
      Q8BPU6, Q8C528, Q8R591, Q9D8P1, Q9JHP7
      Related
      ENSMUSP00000064500.3, ENSMUST00000065767.9
      Conserved Domains (3) summary
      smart00557
      Location:29 → 129
      IG_FLMN; Filamin-type immunoglobulin domains
      pfam00630
      Location:28 → 127
      Filamin; Filamin/ABP280 repeat
      pfam05686
      Location:151 → 484
      Glyco_transf_90; Glycosyl transferase family 90

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      44143060..44158844 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_003946583.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JHP7.1 GenPept UniProtKB/Swiss-Prot:Q9JHP7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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