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    Gucy2f guanylate cyclase 2f [ Mus musculus (house mouse) ]

    Gene ID: 245650, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gucy2fprovided by MGI
    Official Full Name
    guanylate cyclase 2fprovided by MGI
    Primary source
    MGI:MGI:105119
    See related
    Ensembl:ENSMUSG00000042282 AllianceGenome:MGI:105119
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    GC2; GC-F; A930002I06
    Summary
    Predicted to enable guanylate cyclase activity; identical protein binding activity; and peptide receptor activity. Involved in detection of light stimulus involved in visual perception. Located in rod photoreceptor outer segment. Is expressed in nervous system and sensory organ. Orthologous to human GUCY2F (guanylate cyclase 2F, retinal). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    human all
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    Genomic context

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    See Gucy2f in Genome Data Viewer
    Location:
    X F2; X 62.85 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (140862282..140980399, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (142079286..142197276, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene predicted gene 5762 Neighboring gene predicted gene 6373 Neighboring gene STARR-seq mESC enhancer starr_48017 Neighboring gene STARR-positive B cell enhancer mm9_chrX:138662261-138662562 Neighboring gene retinoblastoma binding protein 7 pseudogene Neighboring gene nuclear transport factor 2-like export factor 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Application of functional genomic technologies in a mouse model of retinal degeneration. Shearstone JR, et al. Genomics, 2005 Mar. PMID 15718098
    2. The function of guanylate cyclase 1 and guanylate cyclase 2 in rod and cone photoreceptors. Baehr W, et al. J Biol Chem, 2007 Mar 23. PMID 17255100, Free PMC Article
    3. Guanylate cyclase-activating protein 2 contributes to phototransduction and light adaptation in mouse cone photoreceptors. Vinberg F, et al. J Biol Chem, 2018 May 11. PMID 29549122, Free PMC Article
    4. Esx1, a novel X chromosome-linked homeobox gene expressed in mouse extraembryonic tissues and male germ cells. Li Y, et al. Dev Biol, 1997 Aug 1. PMID 9245514
    5. Enzymatic relay mechanism stimulates cyclic GMP synthesis in rod photoresponse: biochemical and physiological study in guanylyl cyclase activating protein 1 knockout mice. Makino CL, et al. PLoS One, 2012. PMID 23082185, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. rd3 colocalizes and interacts with GC1 and GC2 in rod and cone photoreceptor cells of normal mice
      Title: RD3, the protein associated with Leber congenital amaurosis type 12, is required for guanylate cyclase trafficking in photoreceptor cells.
    2. guanylate cyclase 1 and guanylate cyclase 2 have roles in function of rod and cone photoreceptors
      Title: The function of guanylate cyclase 1 and guanylate cyclase 2 in rod and cone photoreceptors.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanylate cyclase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanylate cyclase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanylate cyclase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables peptide receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-containing complex binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cGMP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cGMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cGMP-mediated signaling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cGMP-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in detection of light stimulus involved in visual perception IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in receptor guanylyl cyclase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in rod photoreceptor outer segment IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    retinal guanylyl cyclase 2
    NP_001007577.1
    XP_006528904.1
    XP_036017858.1
    XP_036017859.1
    XP_036017860.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001007576.2 → NP_001007577.1  retinal guanylyl cyclase 2 precursor

      See identical proteins and their annotated locations for NP_001007577.1

      Status: VALIDATED

      Source sequence(s)
      AK044234, AL671916, AY651761
      Consensus CDS
      CCDS30446.1
      UniProtKB/Swiss-Prot
      Q5SDA5, Q8BLL8
      Related
      ENSMUSP00000044521.4, ENSMUST00000042530.4
      Conserved Domains (4) summary
      smart00044
      Location:848 → 1040
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      cd06371
      Location:54 → 435
      PBP1_sensory_GC_DEF-like; ligand-binding domain of membrane guanylyl cyclases (GC-D, GC-E, and GC-F) that are specifically expressed in sensory tissues
      pfam07701
      Location:824 → 869
      HNOBA; Heme NO binding associated
      cl21453
      Location:545 → 815
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      140862282..140980399 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036161966.1 → XP_036017859.1  retinal guanylyl cyclase 2 isoform X1

      UniProtKB/Swiss-Prot
      Q5SDA5, Q8BLL8
      Conserved Domains (4) summary
      smart00044
      Location:848 → 1040
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      cd06371
      Location:54 → 435
      PBP1_sensory_GC_DEF-like; ligand-binding domain of membrane guanylyl cyclases (GC-D, GC-E, and GC-F) that are specifically expressed in sensory tissues
      pfam07701
      Location:824 → 869
      HNOBA; Heme NO binding associated
      cl21453
      Location:545 → 815
      PKc_like; Protein Kinases, catalytic domain

    2. XM_006528841.5 → XP_006528904.1  retinal guanylyl cyclase 2 isoform X1

      See identical proteins and their annotated locations for XP_006528904.1

      UniProtKB/Swiss-Prot
      Q5SDA5, Q8BLL8
      Conserved Domains (4) summary
      smart00044
      Location:848 → 1040
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      cd06371
      Location:54 → 435
      PBP1_sensory_GC_DEF-like; ligand-binding domain of membrane guanylyl cyclases (GC-D, GC-E, and GC-F) that are specifically expressed in sensory tissues
      pfam07701
      Location:824 → 869
      HNOBA; Heme NO binding associated
      cl21453
      Location:545 → 815
      PKc_like; Protein Kinases, catalytic domain

    3. XM_036161965.1 → XP_036017858.1  retinal guanylyl cyclase 2 isoform X1

      UniProtKB/Swiss-Prot
      Q5SDA5, Q8BLL8
      Conserved Domains (4) summary
      smart00044
      Location:848 → 1040
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      cd06371
      Location:54 → 435
      PBP1_sensory_GC_DEF-like; ligand-binding domain of membrane guanylyl cyclases (GC-D, GC-E, and GC-F) that are specifically expressed in sensory tissues
      pfam07701
      Location:824 → 869
      HNOBA; Heme NO binding associated
      cl21453
      Location:545 → 815
      PKc_like; Protein Kinases, catalytic domain

    4. XM_036161967.1 → XP_036017860.1  retinal guanylyl cyclase 2 isoform X2

      Conserved Domains (2) summary
      cd06371
      Location:54 → 435
      PBP1_sensory_GC_DEF-like; ligand-binding domain of membrane guanylyl cyclases (GC-D, GC-E, and GC-F) that are specifically expressed in sensory tissues
      cl21453
      Location:545 → 708
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5SDA5.1 GenPept UniProtKB/Swiss-Prot:Q5SDA5

    Gene LinkOut

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