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    Fzd3 frizzled class receptor 3 [ Mus musculus (house mouse) ]

    Gene ID: 14365, updated on 4-Jan-2025

    Summary

    Official Symbol
    Fzd3provided by MGI
    Official Full Name
    frizzled class receptor 3provided by MGI
    Primary source
    MGI:MGI:108476
    See related
    Ensembl:ENSMUSG00000007989 AllianceGenome:MGI:108476
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fz3; fz-3; mFz3; D930050A07Rik
    Summary
    Enables Wnt receptor activity. Involved in several processes, including axon guidance; positive regulation of neuroblast proliferation; and sympathetic ganglion development. Acts upstream of or within several processes, including inner ear morphogenesis; nervous system development; and post-anal tail morphogenesis. Located in several cellular components, including apical plasma membrane; filopodium tip; and lateral plasma membrane. Is active in glutamatergic synapse and presynaptic active zone membrane. Colocalizes with presynaptic active zone. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Used to study hydrocephalus. Human ortholog(s) of this gene implicated in Williams-Beuren syndrome and schizophrenia. Orthologous to human FZD3 (frizzled class receptor 3). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Broad expression in whole brain E14.5 (RPKM 1.9), CNS E11.5 (RPKM 1.8) and 17 other tissues See more
    Orthologs
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    Genomic context

    See Fzd3 in Genome Data Viewer
    Location:
    14 D1; 14 34.09 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (65429890..65499912, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (65192441..65262463, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene exostosin-like glycosyltransferase 3 Neighboring gene predicted gene, 52119 Neighboring gene STARR-positive B cell enhancer ABC_E388 Neighboring gene STARR-seq mESC enhancer starr_36964 Neighboring gene predicted gene, 30008 Neighboring gene predicted gene, 41177 Neighboring gene predicted gene 9086 Neighboring gene STARR-seq mESC enhancer starr_36966 Neighboring gene predicted gene, 52141 Neighboring gene F-box protein 16 Neighboring gene STARR-seq mESC enhancer starr_36967 Neighboring gene predicted gene, 41178 Neighboring gene STARR-positive B cell enhancer ABC_E4114 Neighboring gene STARR-positive B cell enhancer ABC_E3120 Neighboring gene predicted gene, 48449 Neighboring gene zinc finger protein 395

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (8)  1 citation

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity  
    enables PDZ domain binding  
    enables PDZ domain binding  
    enables Wnt receptor activity  
    enables Wnt receptor activity PubMed 
    enables Wnt-protein binding  
    enables Wnt-protein binding  
    enables Wnt-protein binding  
    enables protein binding PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway  
    involved_in Wnt signaling pathway, planar cell polarity pathway PubMed 
    involved_in canonical Wnt signaling pathway  
    involved_in canonical Wnt signaling pathway  
    involved_in canonical Wnt signaling pathway  
    acts_upstream_of_or_within cell proliferation in midbrain PubMed 
    acts_upstream_of_or_within commissural neuron axon guidance PubMed 
    involved_in dopaminergic neuron axon guidance PubMed 
    acts_upstream_of_or_within establishment of planar polarity PubMed 
    involved_in hair follicle development PubMed 
    acts_upstream_of_or_within inner ear morphogenesis PubMed 
    acts_upstream_of_or_within midbrain development PubMed 
    acts_upstream_of_or_within motor neuron migration PubMed 
    involved_in negative regulation of execution phase of apoptosis PubMed 
    involved_in negative regulation of mitotic cell cycle, embryonic PubMed 
    acts_upstream_of_or_within neural tube closure PubMed 
    involved_in non-canonical Wnt signaling pathway  
    involved_in positive regulation of neuroblast proliferation PubMed 
    acts_upstream_of_or_within post-anal tail morphogenesis PubMed 
    involved_in response to electrical stimulus  
    involved_in response to xenobiotic stimulus  
    involved_in serotonergic neuron axon guidance PubMed 
    involved_in sympathetic ganglion development PubMed 
    Component Evidence Code Pubs
    located_in apical part of cell PubMed 
    located_in apical plasma membrane PubMed 
    located_in axon PubMed 
    located_in cell surface  
    located_in cytoplasm  
    located_in cytoplasm  
    located_in dendrite PubMed 
    located_in filopodium tip PubMed 
    is_active_in glutamatergic synapse PubMed 
    located_in lateral plasma membrane PubMed 
    located_in neuronal cell body PubMed 
    is_active_in plasma membrane  
    located_in plasma membrane PubMed 
    located_in plasma membrane  
    located_in plasma membrane  
    colocalizes_with presynaptic active zone PubMed 
    is_active_in presynaptic active zone membrane PubMed 

    General protein information

    Preferred Names
    frizzled-3
    Names
    frizzled homolog 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021458.2NP_067433.1  frizzled-3 precursor

      See identical proteins and their annotated locations for NP_067433.1

      Status: VALIDATED

      Source sequence(s)
      AC124489, AC152169, BB664692, BC050965, U43205
      Consensus CDS
      CCDS27212.1
      UniProtKB/Swiss-Prot
      Q61086
      Related
      ENSMUSP00000115325.2, ENSMUST00000131309.3
      Conserved Domains (2) summary
      cd07449
      Location:24150
      CRD_FZ3; Cysteine-rich Wnt-binding domain (CRD) of the frizzled 3 (Fz3) receptor
      pfam01534
      Location:193512
      Frizzled; Frizzled/Smoothened family membrane region

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      65429890..65499912 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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