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    Cryba1 crystallin, beta A1 [ Mus musculus (house mouse) ]

    Gene ID: 12957, updated on 9-Dec-2024

    Summary

    Official Symbol
    Cryba1provided by MGI
    Official Full Name
    crystallin, beta A1provided by MGI
    Primary source
    MGI:MGI:88518
    See related
    Ensembl:ENSMUSG00000000724 AllianceGenome:MGI:88518
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cryb; BA3/A1
    Summary
    Mammalian lens crystallins are divided into alpha, beta, and gamma families. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Beta-crystallins, the most heterogeneous, differ by the presence of the C-terminal extension (present in the basic group, none in the acidic group). Beta-crystallins form aggregates of different sizes and are able to self-associate to form dimers or to form heterodimers with other beta-crystallins. This gene, a beta acidic group member, encodes two proteins (crystallin, beta A3 and crystallin, beta A1) from a single mRNA. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Cryba1 in Genome Data Viewer
    Location:
    11 B5; 11 46.74 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (77609440..77616119, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (77718614..77725293, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_30061 Neighboring gene predicted gene, 23132 Neighboring gene STARR-seq mESC enhancer starr_30062 Neighboring gene STARR-positive B cell enhancer ABC_E10692 Neighboring gene STARR-seq mESC enhancer starr_30063 Neighboring gene nuclear FMR1 interacting protein 2 Neighboring gene STARR-seq mESC enhancer starr_30065 Neighboring gene 60S ribosomal protein L15 pseudogene Neighboring gene STARR-seq mESC enhancer starr_30066 Neighboring gene myosin XVIIIA Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:77597331-77597440 Neighboring gene STARR-seq mESC enhancer starr_30068 Neighboring gene predicted gene 10277

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC130310

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables structural constituent of eye lens IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables structural constituent of eye lens TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within camera-type eye development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in lens development in camera-type eye IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of TOR signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cytokine production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in phagocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of anoikis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of autophagy ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in visual perception IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    beta-crystallin A1
    Names
    beta-A1-crystallin
    beta-A3/A1-crystallin

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001313933.1NP_001300862.1  beta-crystallin A1 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate internal exon compared to variant 1, that causes a frameshift. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AJ239052, CK628527, CN539082
      UniProtKB/TrEMBL
      Q9QXC6
      Conserved Domains (1) summary
      smart00247
      Location:3272
      XTALbg; Beta/gamma crystallins
    2. NM_009965.3NP_034095.1  beta-crystallin A1 isoform 1

      See identical proteins and their annotated locations for NP_034095.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AJ239052, CN539082
      Consensus CDS
      CCDS25084.1
      UniProtKB/Swiss-Prot
      P02525
      UniProtKB/TrEMBL
      Q9QXC6
      Related
      ENSMUSP00000077693.5, ENSMUST00000078623.5
      Conserved Domains (2) summary
      smart00247
      Location:125213
      XTALbg; Beta/gamma crystallins
      pfam00030
      Location:32116
      Crystall; Beta/Gamma crystallin

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      77609440..77616119 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)