Crebbp CREB binding protein [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Crebbpprovided by MGI
Official Full Name: CREB binding proteinprovided by MGI
Primary source: MGI:MGI:1098280
See related: Ensembl:ENSMUSG00000022521 AllianceGenome:MGI:1098280
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CBP; KAT3A; CBP/p300; p300/CBP
Summary: Enables several functions, including DNA-binding transcription factor binding activity; TFIIB-class transcription factor binding activity; and disordered domain specific binding activity. Involved in several processes, including cellular response to virus; face morphogenesis; and regulation of gene expression. Acts upstream of or within cellular response to hepatocyte growth factor stimulus; germ-line stem cell population maintenance; and regulation of gene expression. Located in chromatin and nucleus. Part of RNA polymerase II transcription regulator complex; histone acetyltransferase complex; and outer kinetochore. Is expressed in several structures, including embryo ectoderm; eye; genitourinary system; heart; and skin. Used to study Rubinstein-Taybi syndrome; acute myeloid leukemia; autism spectrum disorder; and myelodysplastic syndrome. Human ortholog(s) of this gene implicated in Rubinstein-Taybi syndrome; acute lymphoblastic leukemia; and acute myeloid leukemia. Orthologous to human CREBBP (CREB binding protein). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in thymus adult (RPKM 18.7), spleen adult (RPKM 14.3) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 16 A1; 16 2.4 cM

Exon count:: 31

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (3899198..4031864, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (4081334..4213957, complement)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Loss of CREBBP and KMT2D cooperate to accelerate lymphomagenesis and shape the lymphoma immune microenvironment.
Title: Loss of CREBBP and KMT2D cooperate to accelerate lymphomagenesis and shape the lymphoma immune microenvironment.
Acetyltransferases CBP/p300 Control Transcriptional Switch of beta-Catenin and Stat1 Promoting Osteoblast Differentiation.
Title: Acetyltransferases CBP/p300 Control Transcriptional Switch of β-Catenin and Stat1 Promoting Osteoblast Differentiation.
The transcriptional coactivator CBP/p300 is an evolutionarily conserved node that promotes longevity in response to mitochondrial stress.
Title: The transcriptional coactivator CBP/p300 is an evolutionarily conserved node that promotes longevity in response to mitochondrial stress.
Glucose-stimulated PGC-1alpha couples with CBP and Runx2 to mediate intervertebral disc degeneration through transactivation of ADAMTS4/5 in diet-induced obesity mice.
Title: Glucose-stimulated PGC-1α couples with CBP and Runx2 to mediate intervertebral disc degeneration through transactivation of ADAMTS4/5 in diet-induced obesity mice.
CBP/p300 and HDAC activities regulate H3K27 acetylation dynamics and zygotic genome activation in mouse preimplantation embryos.
Title: CBP/p300 and HDAC activities regulate H3K27 acetylation dynamics and zygotic genome activation in mouse preimplantation embryos.
The NCOA1-CBP-NF-kappaB transcriptional complex induces inflammation response and triggers endotoxin-induced myocardial dysfunction.
Title: The NCOA1-CBP-NF-κB transcriptional complex induces inflammation response and triggers endotoxin-induced myocardial dysfunction.
Antisense-induced knockdown of cAMP response element-binding protein downregulates Per1 gene expression in the shell region of nucleus accumbens resulting in reduced alcohol consumption in mice.
Title: Antisense-induced knockdown of cAMP response element-binding protein downregulates Per1 gene expression in the shell region of nucleus accumbens resulting in reduced alcohol consumption in mice.
Tachypacing-induced CREB/CD44 signaling contributes to the suppression of L-type calcium channel expression and the development of atrial remodeling.
Title: Tachypacing-induced CREB/CD44 signaling contributes to the suppression of L-type calcium channel expression and the development of atrial remodeling.
A propolis-derived small molecule ameliorates metabolic syndrome in obese mice by targeting the CREB/CRTC2 transcriptional complex.
Title: A propolis-derived small molecule ameliorates metabolic syndrome in obese mice by targeting the CREB/CRTC2 transcriptional complex.
Characterization of the High-Affinity Fuzzy Complex between the Disordered Domain of the E7 Oncoprotein from High-Risk HPV and the TAZ2 Domain of CBP.
Title: Characterization of the High-Affinity Fuzzy Complex between the Disordered Domain of the E7 Oncoprotein from High-Risk HPV and the TAZ2 Domain of CBP.

Submit: New GeneRIF Correction See all GeneRIFs (170)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Gene trapped (1) 1 citation
Targeted (12) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH137561 (e-PCR)
- UniSTS:219648

Crebbp (e-PCR), detects polymorphism
- UniSTS:516615

AW558298 (e-PCR)
- UniSTS:180850

WI-22537 (e-PCR)
- UniSTS:24526

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor binding	ISS Inferred from Sequence or Structural Similarity more info
enables MRF binding	ISO Inferred from Sequence Orthology more info
enables MRF binding	ISS Inferred from Sequence or Structural Similarity more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables RNA polymerase II-specific DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables SMAD binding	ISO Inferred from Sequence Orthology more info
enables TFIIB-class transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables acetyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables cAMP response element binding protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables chromatin DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables damaged DNA binding	ISO Inferred from Sequence Orthology more info
enables damaged DNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables disordered domain specific binding	IPI Inferred from Physical Interaction more info	PubMed
enables histone H2AK5 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AK9 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BK12 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BK5 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K122 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K14 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K18 acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables histone H3K18 acetyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables histone H3K23 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K27 acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables histone H3K27 acetyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables histone H3K36 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K4 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K56 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K9 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H4K12 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H4K16 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H4K5 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H4K8 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone acetyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables histone acetyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables histone acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables histone acetyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables histone acetyltransferase activity	TAS Traceable Author Statement more info
enables histone lactyltransferase (CoA-dependent) activity	IEA Inferred from Electronic Annotation more info
enables molecular adaptor activity	EXP Inferred from Experiment more info	PubMed
enables p53 binding	ISO Inferred from Sequence Orthology more info
enables peptide lactyltransferase (CoA-dependent) activity	ISO Inferred from Sequence Orthology more info
enables peptide lactyltransferase (CoA-dependent) activity	ISS Inferred from Sequence or Structural Similarity more info
enables peptide-lysine-N-acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables peptide-lysine-N-acetyltransferase activity	TAS Traceable Author Statement more info
enables peroxisome proliferator activated receptor binding	ISO Inferred from Sequence Orthology more info
contributes_to protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables transcription coactivator activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription coactivator activity	IDA Inferred from Direct Assay more info	PubMed
enables transcription coactivator activity	ISO Inferred from Sequence Orthology more info
enables transcription coactivator activity	ISS Inferred from Sequence or Structural Similarity more info
enables transcription coactivator activity	TAS Traceable Author Statement more info	PubMed
enables transcription coactivator binding	ISO Inferred from Sequence Orthology more info
enables transcription corepressor activity	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in N-terminal peptidyl-lysine acetylation	ISO Inferred from Sequence Orthology more info
involved_in N-terminal peptidyl-lysine acetylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in behavioral response to cocaine	ISO Inferred from Sequence Orthology more info
involved_in canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in cellular response to UV	ISO Inferred from Sequence Orthology more info
involved_in cellular response to UV	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within cellular response to hepatocyte growth factor stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to nutrient levels	ISO Inferred from Sequence Orthology more info
involved_in cellular response to virus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in face morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within germ-line stem cell population maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in long-term memory	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interferon-beta production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase I	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase I	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of viral process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of CREB transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-binding transcription factor activity	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of G1/S transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell adhesion molecule production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of dendritic spine development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of double-strand break repair via homologous recombination	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of double-strand break repair via homologous recombination	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of gene expression	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of non-canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein localization to nucleus	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transforming growth factor beta receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in protein acetylation	ISO Inferred from Sequence Orthology more info
involved_in protein destabilization	ISO Inferred from Sequence Orthology more info
involved_in protein destabilization	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein modification process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in rhythmic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in PML body	ISO Inferred from Sequence Orthology more info	PubMed
part_of RNA polymerase II transcription regulator complex	IDA Inferred from Direct Assay more info	PubMed
located_in chromatin	IDA Inferred from Direct Assay more info	PubMed
located_in chromatin	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
part_of histone acetyltransferase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of histone acetyltransferase complex	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of outer kinetochore	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	IMP Inferred from Mutant Phenotype more info	PubMed
part_of transcription regulator complex	IBA Inferred from Biological aspect of Ancestor more info
part_of transcription regulator complex	IDA Inferred from Direct Assay more info	PubMed
part_of transcription regulator complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: histone lysine acetyltransferase CREBBP

Names: protein lactyltransferas CREBBP; protein-lysine acetyltransferase CREBBP

NP_001020603.1

EC 2.3.1.48

XP_006521814.1

EC 2.3.1.48

XP_006521815.1

EC 2.3.1.48

XP_006521816.1

EC 2.3.1.48

XP_006521817.1

EC 2.3.1.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001025432.1 → NP_001020603.1 histone lysine acetyltransferase CREBBP

See identical proteins and their annotated locations for NP_001020603.1

Status: VALIDATED

Source sequence(s)

BC010297, BC072594, BU705617, CAAA01026247

Consensus CDS

CCDS27915.1

UniProtKB/Swiss-Prot

E9QPH4, P45481

UniProtKB/TrEMBL

F8VPR5

Related

ENSMUSP00000023165.7, ENSMUST00000023165.9

Conserved Domains (10) summary

cd05495
Location:1088 → 1195

Bromo_cbp_like; Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to ...

smart00551
Location:1767 → 1845

ZnF_TAZ; TAZ zinc finger, present in p300 and CBP

COG5076
Location:942 → 1194

COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]

cd02337
Location:1706 → 1746

ZZ_CBP; Zinc finger, ZZ type. Zinc finger present in CBP/p300 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. CREB-binding protein (CBP) is a large multidomain protein that ...

cd15802
Location:1207 → 1279

RING_CBP-p300; atypical RING domain found in CREB-binding protein and p300 histone acetyltransferases

cd15557
Location:1281 → 1312

PHD_CBP_p300; PHD finger found in CREB-binding protein (CBP) and histone acetyltransferase p300

pfam02135
Location:362 → 429

zf-TAZ; TAZ zinc finger

pfam02172
Location:586 → 666

KIX; KIX domain

pfam08214
Location:1343 → 1650

HAT_KAT11; Histone acetylation protein

pfam09030
Location:2035 → 2112

Creb_binding; Creb binding

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000082.7 Reference GRCm39 C57BL/6J

Range

3899198..4031864 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006521754.5 → XP_006521817.1 histone lysine acetyltransferase CREBBP isoform X4

UniProtKB/Swiss-Prot

E9QPH4, P45481

UniProtKB/TrEMBL

A0A0U1RQB6

Related

ENSMUSP00000146330.2, ENSMUST00000205765.2

Conserved Domains (12) summary

cd05495
Location:1050 → 1157

Bromo_cbp_like; Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to ...

smart00551
Location:1729 → 1807

ZnF_TAZ; TAZ zinc finger, present in p300 and CBP

PHA03247
Location:649 → 999

PHA03247; large tegument protein UL36; Provisional

COG5076
Location:904 → 1156

COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]

cd02337
Location:1668 → 1708

ZZ_CBP; Zinc finger, ZZ type. Zinc finger present in CBP/p300 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. CREB-binding protein (CBP) is a large multidomain protein that ...

cd15802
Location:1169 → 1241

RING_CBP-p300; atypical RING domain found in CREB-binding protein and p300 histone acetyltransferases

cd15557
Location:1243 → 1274

PHD_CBP_p300; PHD finger found in CREB-binding protein (CBP) and histone acetyltransferase p300

pfam09606
Location:1923 → 2374

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

pfam02135
Location:362 → 404

zf-TAZ; TAZ zinc finger

pfam02172
Location:548 → 628

KIX; KIX domain

pfam08214
Location:1305 → 1516

HAT_KAT11; Histone acetylation protein

pfam09030
Location:1997 → 2077

Creb_binding; Creb binding
XM_006521753.5 → XP_006521816.1 histone lysine acetyltransferase CREBBP isoform X3

UniProtKB/Swiss-Prot

E9QPH4, P45481

Conserved Domains (12) summary

cd05495
Location:1050 → 1157

Bromo_cbp_like; Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to ...

smart00551
Location:1739 → 1817

ZnF_TAZ; TAZ zinc finger, present in p300 and CBP

PHA03247
Location:649 → 999

PHA03247; large tegument protein UL36; Provisional

COG5076
Location:904 → 1156

COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]

cd02337
Location:1678 → 1718

ZZ_CBP; Zinc finger, ZZ type. Zinc finger present in CBP/p300 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. CREB-binding protein (CBP) is a large multidomain protein that ...

cd15802
Location:1169 → 1251

RING_CBP-p300; atypical RING domain found in CREB-binding protein and p300 histone acetyltransferases

cd15557
Location:1253 → 1284

PHD_CBP_p300; PHD finger found in CREB-binding protein (CBP) and histone acetyltransferase p300

pfam09606
Location:1933 → 2384

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

pfam02135
Location:362 → 404

zf-TAZ; TAZ zinc finger

pfam02172
Location:548 → 628

KIX; KIX domain

pfam08214
Location:1315 → 1526

HAT_KAT11; Histone acetylation protein

pfam09030
Location:2007 → 2087

Creb_binding; Creb binding
XM_006521751.5 → XP_006521814.1 histone lysine acetyltransferase CREBBP isoform X1

UniProtKB/Swiss-Prot

E9QPH4, P45481

Conserved Domains (12) summary

cd05495
Location:1088 → 1195

Bromo_cbp_like; Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to ...

smart00551
Location:1777 → 1855

ZnF_TAZ; TAZ zinc finger, present in p300 and CBP

PHA03247
Location:687 → 1037

PHA03247; large tegument protein UL36; Provisional

COG5076
Location:942 → 1194

COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]

cd02337
Location:1716 → 1756

ZZ_CBP; Zinc finger, ZZ type. Zinc finger present in CBP/p300 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. CREB-binding protein (CBP) is a large multidomain protein that ...

cd15802
Location:1207 → 1289

RING_CBP-p300; atypical RING domain found in CREB-binding protein and p300 histone acetyltransferases

cd15557
Location:1291 → 1322

PHD_CBP_p300; PHD finger found in CREB-binding protein (CBP) and histone acetyltransferase p300

pfam09606
Location:1971 → 2422

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

pfam02135
Location:362 → 429

zf-TAZ; TAZ zinc finger

pfam02172
Location:586 → 666

KIX; KIX domain

pfam08214
Location:1353 → 1564

HAT_KAT11; Histone acetylation protein

pfam09030
Location:2045 → 2125

Creb_binding; Creb binding
XM_006521752.4 → XP_006521815.1 histone lysine acetyltransferase CREBBP isoform X2

UniProtKB/Swiss-Prot

E9QPH4, P45481

Conserved Domains (12) summary

cd05495
Location:1083 → 1190

Bromo_cbp_like; Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to ...

smart00551
Location:1772 → 1850

ZnF_TAZ; TAZ zinc finger, present in p300 and CBP

PHA03247
Location:680 → 1032

PHA03247; large tegument protein UL36; Provisional

COG5076
Location:937 → 1189

COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]

cd02337
Location:1711 → 1751

ZZ_CBP; Zinc finger, ZZ type. Zinc finger present in CBP/p300 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. CREB-binding protein (CBP) is a large multidomain protein that ...

cd15802
Location:1202 → 1284

RING_CBP-p300; atypical RING domain found in CREB-binding protein and p300 histone acetyltransferases

cd15557
Location:1286 → 1317

PHD_CBP_p300; PHD finger found in CREB-binding protein (CBP) and histone acetyltransferase p300

pfam09606
Location:1966 → 2417

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

pfam02135
Location:362 → 429

zf-TAZ; TAZ zinc finger

pfam02172
Location:586 → 666

KIX; KIX domain

pfam08214
Location:1348 → 1559

HAT_KAT11; Histone acetylation protein

pfam09030
Location:2040 → 2120

Creb_binding; Creb binding