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    Hdhd5 haloacid dehalogenase like hydrolase domain containing 5 [ Mus musculus (house mouse) ]

    Gene ID: 214932, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Hdhd5provided by MGI
    Official Full Name
    haloacid dehalogenase like hydrolase domain containing 5provided by MGI
    Primary source
    MGI:MGI:2136976
    See related
    Ensembl:ENSMUSG00000058979 AllianceGenome:MGI:2136976
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cecr5; A930002G03Rik
    Summary
    Predicted to be involved in glycerophospholipid biosynthetic process. Located in mitochondrion. Orthologous to human HDHD5 (haloacid dehalogenase like hydrolase domain containing 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in thymus adult (RPKM 11.2), kidney adult (RPKM 7.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Hdhd5 in Genome Data Viewer
    Location:
    6 F1; 6 56.95 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (120486453..120508319, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (120509492..120531363, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:120416743-120416991 Neighboring gene STARR-positive B cell enhancer ABC_E685 Neighboring gene STARR-positive B cell enhancer ABC_E10406 Neighboring gene interleukin 17 receptor A Neighboring gene transmembrane protein 121B Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:120479310-120479463 Neighboring gene RIKEN cDNA 1700072O05 gene Neighboring gene nonconserved acetylation island sequence M73 enhancer Neighboring gene STARR-positive B cell enhancer ABC_E6478 Neighboring gene STARR-positive B cell enhancer ABC_E8125 Neighboring gene CECR2, histone acetyl-lysine reader Neighboring gene predicted gene, 53339

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Analysis of the cat eye syndrome critical region in humans and the region of conserved synteny in mice: a search for candidate genes at or near the human chromosome 22 pericentromere. Footz TK, et al. Genome Res, 2001 Jun. PMID 11381032, Free PMC Article
    2. Sex-biased gene and microRNA expression in the developing mouse brain is associated with neurodevelopmental functions and neurological phenotypes. Szakats S, et al. Biol Sex Differ, 2023 Sep 7. PMID 37679839, Free PMC Article
    3. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    4. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
    5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • MGC25951

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in glycerophospholipid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    haloacid dehalogenase-like hydrolase domain-containing 5
    Names
    cat eye syndrome chromosome region, candidate 5 homolog
    cat eye syndrome critical region protein 5 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_144815.2 → NP_659064.1  haloacid dehalogenase-like hydrolase domain-containing 5 precursor

      See identical proteins and their annotated locations for NP_659064.1

      Status: VALIDATED

      Source sequence(s)
      BC014705
      Consensus CDS
      CCDS20483.1
      UniProtKB/Swiss-Prot
      Q91WM2
      Related
      ENSMUSP00000074775.7, ENSMUST00000075303.7
      Conserved Domains (2) summary
      TIGR01456
      Location:47 → 358
      CECR5; HAD-superfamily class IIA hydrolase, TIGR01456, CECR5
      pfam13344
      Location:49 → 152
      Hydrolase_6; Haloacid dehalogenase-like hydrolase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      120486453..120508319 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030255305.1 → XP_030111165.1  haloacid dehalogenase-like hydrolase domain-containing 5 isoform X1

      Conserved Domains (1) summary
      TIGR01456
      Location:1 → 236
      CECR5; HAD-superfamily class IIA hydrolase, TIGR01456, CECR5

    2. XM_036166013.1 → XP_036021906.1  haloacid dehalogenase-like hydrolase domain-containing 5 isoform X1

      Conserved Domains (1) summary
      TIGR01456
      Location:1 → 236
      CECR5; HAD-superfamily class IIA hydrolase, TIGR01456, CECR5

    3. XM_036166014.1 → XP_036021907.1  haloacid dehalogenase-like hydrolase domain-containing 5 isoform X3

      Conserved Domains (1) summary
      TIGR01456
      Location:1 → 190
      CECR5; HAD-superfamily class IIA hydrolase, TIGR01456, CECR5

    4. XM_011241282.3 → XP_011239584.1  haloacid dehalogenase-like hydrolase domain-containing 5 isoform X2

      See identical proteins and their annotated locations for XP_011239584.1

      Conserved Domains (1) summary
      TIGR01456
      Location:24 → 192
      CECR5; HAD-superfamily class IIA hydrolase, TIGR01456, CECR5

    5. XM_030255308.1 → XP_030111168.1  haloacid dehalogenase-like hydrolase domain-containing 5 isoform X4

      Conserved Domains (1) summary
      TIGR01456
      Location:1 → 151
      CECR5; HAD-superfamily class IIA hydrolase, TIGR01456, CECR5

    6. XM_030255309.1 → XP_030111169.1  haloacid dehalogenase-like hydrolase domain-containing 5 isoform X4

      Conserved Domains (1) summary
      TIGR01456
      Location:1 → 151
      CECR5; HAD-superfamily class IIA hydrolase, TIGR01456, CECR5

    7. XM_030255307.2 → XP_030111167.1  haloacid dehalogenase-like hydrolase domain-containing 5 isoform X4

      Conserved Domains (1) summary
      TIGR01456
      Location:1 → 151
      CECR5; HAD-superfamily class IIA hydrolase, TIGR01456, CECR5

    8. XM_036166015.1 → XP_036021908.1  haloacid dehalogenase-like hydrolase domain-containing 5 isoform X4

      Conserved Domains (1) summary
      TIGR01456
      Location:1 → 151
      CECR5; HAD-superfamily class IIA hydrolase, TIGR01456, CECR5

    RNA

    1. XR_868852.4 RNA Sequence

    2. XR_003956182.2 RNA Sequence

    3. XR_003956183.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91WM2.1 GenPept UniProtKB/Swiss-Prot:Q91WM2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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