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    Prss41 serine protease 41 [ Mus musculus (house mouse) ]

    Gene ID: 71003, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Prss41provided by MGI
    Official Full Name
    serine protease 41provided by MGI
    Primary source
    MGI:MGI:1918253
    See related
    Ensembl:ENSMUSG00000024114 AllianceGenome:MGI:1918253
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tessp1; Tessp-1; 4931440B09Rik
    Summary
    Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Located in plasma membrane. Is expressed in eye; heart; lung; male reproductive gland or organ; and smooth muscle tissue. Orthologous to human PRSS41 (serine protease 41). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis adult (RPKM 3.8), colon adult (RPKM 1.0) and 10 other tissues See more
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    Genomic context

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    See Prss41 in Genome Data Viewer
    Location:
    17 A3.3; 17 12.09 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (24055759..24063190, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (23836785..23844219, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene serine/arginine repetitive matrix 2 Neighboring gene STARR-positive B cell enhancer ABC_E11792 Neighboring gene elongin B Neighboring gene serine protease 33 Neighboring gene serine protease 32 Neighboring gene serine protease 21

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A testis-specific serine protease, Prss41/Tessp-1, is necessary for the progression of meiosis during murine in vitro spermatogenesis. Yoneda R, et al. Biochem Biophys Res Commun, 2013 Nov 8. PMID 24129193
    2. TESSP-1: a novel serine protease gene expressed in the spermatogonia and spermatocytes of adult mouse testes. Takano N, et al. Mol Reprod Dev, 2005 Jan. PMID 15515062
    3. Two distinct localization patterns of testis-specific serine protease 1 (TESSP1) in the seminiferous tubules of the mouse testis. Takano N, et al. Zoolog Sci, 2009 Apr. PMID 19798924
    4. Identification of a subgroup of glycosylphosphatidylinositol-anchored tryptases. Wong GW, et al. Biochem Biophys Res Commun, 2005 Oct 21. PMID 16143303
    5. Mouse chromosome 17A3.3 contains 13 genes that encode functional tryptic-like serine proteases with distinct tissue and cell expression patterns. Wong GW, et al. J Biol Chem, 2004 Jan 23. PMID 14583634

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the Prss/Tessp proteases are important for the progression of meiosis at each stage.
      Title: A testis-specific serine protease, Prss41/Tessp-1, is necessary for the progression of meiosis during murine in vitro spermatogenesis.
    2. The results of this study suggest that TESSP1 is predominantly localized in the plasma membrane of spermatogonia and Sertoli cells in the basal compartment.
      Title: Two distinct localization patterns of testis-specific serine protease 1 (TESSP1) in the seminiferous tubules of the mouse testis.
    3. A novel type of serine protease, designated testis-specific serine protease 1 (TESSP-1), from the adult mouse testis was cloned.
      Title: TESSP-1: a novel serine protease gene expressed in the spermatogonia and spermatocytes of adult mouse testes.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in intracellular organelle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in side of membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    serine protease 41
    Names
    protease, serine 41
    testis serine protease 1
    testis-specific serine protease 1
    NP_001405693.1
    NP_001405694.1
    NP_081920.1
    XP_036016678.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001418764.1 → NP_001405693.1  serine protease 41 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC122821

    2. NM_001418765.1 → NP_001405694.1  serine protease 41 isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      AC122821
      Related
      ENSMUSP00000122453.2, ENSMUST00000151797.3

    3. NM_027644.2 → NP_081920.1  serine protease 41 isoform 1 precursor

      See identical proteins and their annotated locations for NP_081920.1

      Status: VALIDATED

      Source sequence(s)
      AC122821
      Consensus CDS
      CCDS28466.1
      UniProtKB/Swiss-Prot
      Q8BX01, Q920S2
      UniProtKB/TrEMBL
      B9EK99
      Related
      ENSMUSP00000024926.8, ENSMUST00000024926.14
      Conserved Domains (2) summary
      smart00020
      Location:52 → 289
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:53 → 290
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      24055759..24063190 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036160785.1 → XP_036016678.1  serine protease 41 isoform X1

      UniProtKB/TrEMBL
      B9EK99
      Conserved Domains (1) summary
      cd00190
      Location:84 → 321
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q920S2.1 GenPept UniProtKB/Swiss-Prot:Q920S2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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