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    Eprs1 glutamyl-prolyl-tRNA synthetase 1 [ Mus musculus (house mouse) ]

    Gene ID: 107508, updated on 9-Dec-2024

    Summary

    Official Symbol
    Eprs1provided by MGI
    Official Full Name
    glutamyl-prolyl-tRNA synthetase 1provided by MGI
    Primary source
    MGI:MGI:97838
    See related
    Ensembl:ENSMUSG00000026615 AllianceGenome:MGI:97838
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Eprs; Qprs; 2410081F06Rik; 3010002K18Rik
    Summary
    Enables proline-tRNA ligase activity. Involved in several processes, including cellular response to insulin stimulus; cellular response to type II interferon; and prolyl-tRNA aminoacylation. Located in plasma membrane. Part of GAIT complex and aminoacyl-tRNA synthetase multienzyme complex. Is expressed in several structures, including alimentary system; axial skeleton; cerebellum; craniocervical region bone; and liver. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 15. Orthologous to human EPRS1 (glutamyl-prolyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 17.5), liver E14 (RPKM 12.9) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Eprs1 in Genome Data Viewer
    Location:
    1 H5; 1 89.5 cM
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (185093614..185160557)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (185361417..185428360)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene isoleucine-tRNA synthetase 2, mitochondrial Neighboring gene RIKEN cDNA 2010103J01 gene Neighboring gene microRNA 215 Neighboring gene STARR-seq mESC enhancer starr_03326 Neighboring gene STARR-seq mESC enhancer starr_03328 Neighboring gene 3'(2'), 5'-bisphosphate nucleotidase 1 Neighboring gene STARR-positive B cell enhancer ABC_E4403 Neighboring gene STARR-positive B cell enhancer ABC_E3350 Neighboring gene RIKEN cDNA 9630028B13 gene Neighboring gene predicted gene 2061 Neighboring gene solute carrier family 30, member 10

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables GTPase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables GTPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA stem-loop binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA stem-loop binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables glutamate-tRNA ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables glutamate-tRNA ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables proline-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables proline-tRNA ligase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables proline-tRNA ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables proline-tRNA ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables zinc ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    part_of GAIT complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of GAIT complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of aminoacyl-tRNA synthetase multienzyme complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of aminoacyl-tRNA synthetase multienzyme complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of aminoacyl-tRNA synthetase multienzyme complex ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of ribonucleoprotein complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    bifunctional glutamate/proline--tRNA ligase
    Names
    bifunctional aminoacyl-tRNA synthetase
    glutamine-proline-tRNA synthetase
    NP_001344403.1
    NP_084011.1
    XP_017176142.1
    XP_030110720.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357474.1NP_001344403.1  bifunctional glutamate/proline--tRNA ligase isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC129195, AC131980
      UniProtKB/TrEMBL
      B9EIU1
      Conserved Domains (3) summary
      PRK08661
      Location:10261519
      PRK08661; prolyl-tRNA synthetase; Provisional
      cd00936
      Location:760809
      WEPRS_RNA; WEPRS_RNA binding domain. This short RNA-binding domain is found in several higher eukaryote aminoacyl-tRNA synthetases (aaRSs). It is found in multiple copies in eukaryotic bifunctional glutamyl-prolyl-tRNA synthetases (EPRS) in a region that separates ...
      cl27212
      Location:6718
      GlnS; Glutamyl- or glutaminyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]
    2. NM_029735.2NP_084011.1  bifunctional glutamate/proline--tRNA ligase isoform 1

      See identical proteins and their annotated locations for NP_084011.1

      Status: VALIDATED

      Source sequence(s)
      AI845980, AK141072, BC058337, BC094679, CB520692, CF537682, CK635189
      Consensus CDS
      CCDS35818.1
      UniProtKB/Swiss-Prot
      E9QKC4, Q3UFJ2, Q4VC16, Q8CGC7
      UniProtKB/TrEMBL
      B9EIU1
      Related
      ENSMUSP00000045841.8, ENSMUST00000046514.13
      Conserved Domains (8) summary
      cd10309
      Location:74157
      GST_C_GluProRS_N; Glutathione S-transferase C-terminal-like, alpha helical domain of bifunctional Glutamyl-Prolyl-tRNA synthetase
      PLN02907
      Location:6711
      PLN02907; glutamate-tRNA ligase
      PRK08661
      Location:10191512
      PRK08661; prolyl-tRNA synthetase; Provisional
      cd00778
      Location:10231286
      ProRS_core_arch_euk; Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of ...
      cd00862
      Location:12921512
      ProRS_anticodon_zinc; ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in ...
      pfam00458
      Location:753805
      WHEP-TRS; WHEP-TRS domain
      pfam00749
      Location:197502
      tRNA-synt_1c; tRNA synthetases class I (E and Q), catalytic domain
      pfam03950
      Location:504681
      tRNA-synt_1c_C; tRNA synthetases class I (E and Q), anti-codon binding domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      185093614..185160557
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017320653.2XP_017176142.1  bifunctional glutamate/proline--tRNA ligase isoform X2

      UniProtKB/TrEMBL
      B9EIU1
      Conserved Domains (4) summary
      PLN02907
      Location:2454
      PLN02907; glutamate-tRNA ligase
      PRK08661
      Location:7621255
      PRK08661; prolyl-tRNA synthetase; Provisional
      cd00936
      Location:496545
      WEPRS_RNA; WEPRS_RNA binding domain. This short RNA-binding domain is found in several higher eukaryote aminoacyl-tRNA synthetases (aaRSs). It is found in multiple copies in eukaryotic bifunctional glutamyl-prolyl-tRNA synthetases (EPRS) in a region that separates ...
      pfam00458
      Location:569621
      WHEP-TRS; WHEP-TRS domain
    2. XM_030254860.2XP_030110720.1  bifunctional glutamate/proline--tRNA ligase isoform X1

      UniProtKB/TrEMBL
      B9EIU1
      Conserved Domains (4) summary
      PLN02907
      Location:2461
      PLN02907; glutamate-tRNA ligase
      PRK08661
      Location:7691262
      PRK08661; prolyl-tRNA synthetase; Provisional
      cd00936
      Location:503552
      WEPRS_RNA; WEPRS_RNA binding domain. This short RNA-binding domain is found in several higher eukaryote aminoacyl-tRNA synthetases (aaRSs). It is found in multiple copies in eukaryotic bifunctional glutamyl-prolyl-tRNA synthetases (EPRS) in a region that separates ...
      pfam00458
      Location:576628
      WHEP-TRS; WHEP-TRS domain