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    Tmem132d transmembrane protein 132D [ Mus musculus (house mouse) ]

    Gene ID: 243274, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Tmem132dprovided by MGI
    Official Full Name
    transmembrane protein 132Dprovided by MGI
    Primary source
    MGI:MGI:3044963
    See related
    Ensembl:ENSMUSG00000034310 AllianceGenome:MGI:3044963
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    C630028F04Rik
    Summary
    Predicted to be located in membrane. Is expressed in brain and skeleton. Orthologous to human TMEM132D (transmembrane protein 132D). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in cortex adult (RPKM 4.3), frontal lobe adult (RPKM 3.8) and 6 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tmem132d in Genome Data Viewer
    Location:
    5 G1.3; 5 66.32 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (127860555..128510141, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (127783491..128433077, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 132C, opposite strand Neighboring gene transmembrane protein 132C Neighboring gene STARR-seq mESC enhancer starr_14401 Neighboring gene STARR-seq mESC enhancer starr_14404 Neighboring gene STARR-seq mESC enhancer starr_14405 Neighboring gene solute carrier family 15, member 4 Neighboring gene STARR-seq mESC enhancer starr_14412 Neighboring gene STARR-seq mESC enhancer starr_14414 Neighboring gene glycosyltransferase 1 domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_14415 Neighboring gene STARR-seq mESC enhancer starr_14419 Neighboring gene STARR-seq mESC enhancer starr_14420 Neighboring gene STARR-seq mESC enhancer starr_14421 Neighboring gene predicted gene, 33738 Neighboring gene predicted gene, 38612

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Polymorphism in Tmem132d regulates expression and anxiety-related behavior through binding of RNA polymerase II complex. Naik RR, et al. Transl Psychiatry, 2018 Jan 10. PMID 29317594, Free PMC Article
    2. Molecular cloning of a novel transmembrane protein MOLT expressed by mature oligodendrocytes. Nomoto H, et al. J Biochem, 2003 Aug. PMID 12966072
    3. Differential expression of the Tmem132 family genes in the developing mouse nervous system. Wang Y, et al. Gene Expr Patterns, 2022 Sep. PMID 35690356, Free PMC Article
    4. Identification of new ciliary signaling pathways in the brain and insights into neurological disorders. Loukil A, et al. bioRxiv, 2023 Dec 21. PMID 38187761, Free PMC Article
    5. USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities. Liu C, et al. Sci Adv, 2023 May 19. PMID 37196079, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Higher expression of Tmem132d in the anterior cingulate cortex causes increased anxiety-related behavior
      Title: Polymorphism in Tmem132d regulates expression and anxiety-related behavior through binding of RNA polymerase II complex.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane protein 132D
    Names
    mature OL transmembrane protein
    mature oligodendrocytes transmembrane protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172885.2 → NP_766473.1  transmembrane protein 132D precursor

      See identical proteins and their annotated locations for NP_766473.1

      Status: PROVISIONAL

      Source sequence(s)
      AK083210
      Consensus CDS
      CCDS39287.1
      UniProtKB/Swiss-Prot
      A0A0R4J0I2, B2RU39, Q76HP3, Q8C422
      Related
      ENSMUSP00000043633.7, ENSMUST00000044441.8
      Conserved Domains (3) summary
      pfam15705
      Location:49 → 178
      TMEM132D_N; Mature oligodendrocyte transmembrane protein, TMEM132D, N-term
      pfam15706
      Location:884 → 970
      TMEM132D_C; Mature oligodendrocyte transmembrane protein, TMEM132D, C-term
      pfam16070
      Location:435 → 777
      TMEM132; Transmembrane protein family 132

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      127860555..128510141 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q76HP3.2 GenPept UniProtKB/Swiss-Prot:Q76HP3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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